Composite oral fat nano milk and preparing method thereof

A fat nanoemulsion, egg yolk lecithin technology, applied in the directions of drug combination, pharmaceutical formula, emulsion delivery, etc., can solve the problems of difficult absorption, poor bioavailability, poor stability, etc., achieve good antioxidant performance, improve stability Good performance and stability

Inactive Publication Date: 2016-04-06
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are few reports of linseed oil and medium-chain triglyceride (MCT) binary compound fat nanoemulsion. The oil soft capsule preparation is not easy to absorb or not completely absorbed, and the taste is poor during taking.
Ordinary fat emulsion has large particle size, poor stability after long storage time, and poor bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A. Water phase: Mix 24g of glycerin, 805g of Tween and 880ml of purified water evenly, and preheat to 60°C, set aside;

[0024] B. Oil phase: Mix 25g medium-chain triglyceride (MCT), 25g linseed oil, 25g egg yolk lecithin, and 0.5g vitamin E at high speed until mixed evenly, and set aside;

[0025] C. Slowly pour the oil phase material into the water phase material, and use a high-speed shear mixer at 100,000 revolutions per minute, shear and stir for 5 minutes, repeat 3 times, and prepare colostrum;

[0026] D. Under the condition of pressure of 103Mpa, the colostrum was repeatedly homogenized 3 times with a micro-fluidic high-pressure homogenizer, and the oral compound medium-chain triglyceride (MCT) and linseed oil nanoemulsion was prepared.

[0027] E. Filter and sterilize the homogenized emulsion through a 0.4 μm microporous membrane filter, pour it into a packaging container in a sterile GMP clean environment, fill it with nitrogen and seal it.

Embodiment 2

[0029] A. Water phase: Mix 50g of glycerin, 8050g of Tween and 750ml of purified water evenly, and preheat to 50°C, set aside;

[0030] B. Oil phase: Mix 50g of medium chain triglyceride (MCT), 50g of linseed oil, 25g of egg yolk lecithin, and 0.5g of vitamin E at high speed until mixed evenly, and set aside;

[0031] C. Slowly pour the oil phase material into the water phase material, and use a high-speed shear mixer at 100,000 revolutions per minute, shear and stir for 5 minutes, repeat 3 times, and prepare colostrum;

[0032] D. Under the condition of a pressure of 103Mpa, the colostrum was repeatedly homogenized twice with a micro-fluidic high-pressure homogenizer, and the oral compound medium-chain triglyceride (MCT) and linseed oil nanoemulsion was prepared.

[0033] E. Filter and sterilize the homogenized emulsion through a 0.4 μm microporous membrane filter, pour it into a packaging container in a sterile GMP clean environment, fill it with nitrogen and seal it.

Embodiment 3

[0035] A. Water phase: Mix 50g of glycerin, 8025g of Tween and 830ml of purified water evenly, and preheat to 70°C, set aside;

[0036] B. Oil phase: Mix 35g of medium chain triglyceride (MCT), 15g of linseed oil, 25g of egg yolk lecithin, and 0.5g of vitamin E at high speed until mixed evenly, and set aside;

[0037] C. Slowly pour the oil phase material into the water phase material, and use a high-speed shear mixer at 100,000 revolutions per minute, shear and stir for 5 minutes, repeat 3 times, and prepare colostrum;

[0038] D. Under the condition of pressure of 103Mpa, the colostrum was repeatedly homogenized 3 times with a micro-fluidic high-pressure homogenizer, and the oral compound medium-chain triglyceride (MCT) and linseed oil nanoemulsion was prepared.

[0039] E. Filter and sterilize the homogenized emulsion through a 0.4 μm microporous membrane filter, pour it into a packaging container in a sterile GMP clean environment, fill it with nitrogen and seal it.

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Abstract

The invention discloses composite oral fat nano milk and a preparing method thereof. The composite oral fat nano milk is prepared from the following components in parts by weight: 10-50 parts of flaxseed oil, 10-90 parts of medium chain triglyceride (MCT), 0.2-0.5 parts of vitamin E, 24-50 parts of glycerinum, 1-50 parts of egg yolk lecithin, 1-50 parts of tween 80 and 700-950 parts of purified water. The invention adopts the oral fat nano milk prepared from the flaxseed oil and MCT, so fatty nutrient elements especially omega-3unsaturatted fatty acid can be supplemented and medium and long chain fatty acids are matched to improve the absorption speed of the fatty nutrient elements. The egg yolk lecithin-tween 80 mixed emulsifier is adopted to increase the lecithin nutrient component, and promotes cholesterol metabolism, and due to the nutrient elements of the omega-3unsaturatted fatty acid and the lecithin, the product has well adjusting action for metabolic disturbance of human body fat. The fat milk is made into nano milk, and the bioavailability and stability of the preparation can be improved compared with common milk.

Description

technical field [0001] The invention belongs to the field of enteral nutrition, and in particular relates to a composite oral fat nanoemulsion and a preparation method thereof. Background technique [0002] Linseed oil is a functional oil with special nutritional and physiological functions, containing 40-65% linolenic acid. Linolenic acid, also known as omega-3 fatty acid, is an essential fatty acid for the human body. It is the basic substance that constitutes cell membranes and biological enzymes. It also plays an important role in maintaining lipoprotein balance, lowering blood fat, regulating cholesterol metabolism, lowering blood pressure, and antithrombotic. At the same time, it can also intervene in the human body in various ways to intervene in cytokines related to tumor cachexia, thereby improving the abnormal metabolic status of tumor patients, correcting symptoms related to cachexia, and increasing the intake of nutrients in tumor patients. [0003] Medium-chain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/24A61K47/26A61K47/22A61K36/55A61P3/04A61K31/215
CPCA61K9/1075A61K31/215A61K36/55A61K47/22A61K47/24A61K47/26
Inventor 罗明琍刘欢曾荣华李金华袁诚杨占东谢嘉信
Owner GUANGZHOU HANFANG PHARMA
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