The preparation method of trifluoromethylbenzothiophene derivative

A technology for thiophene derivatives and trifluoromethylbenzene is applied in the field of preparation of trifluoromethyl-containing benzothiophene derivatives, which can solve the problems of pollution in the preparation process, complicated technological process and high production cost, and achieve a cheap synthesis system. , the process is simple, the effect of low cost
CN105503822BInactive Publication Date: 2017-11-24WENZHOU UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WENZHOU UNIVERSITY
Publication Date
2017-11-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method for a trifluoromethyl benzothiophene derivative and a purification method for a product of the preparation method. The preparation method comprises the steps that an alkynol compound containing methyl fluoride building blocks or a derivative of the alkynol compound is taken as a substrate, disulfide is added into the substrate, and a crude product is prepared through a heating reaction under the nitrogen atmosphere of an elementary substance iodine, benzoyl peroxide and an iron catalyst by taking a nitromethane solution as solvent. The crude product is purified through the steps that filtering, iodine removing and solvent removing are performed on the crude product to obtain residua; chromatography is performed on the residua by adopting a silicagel column, elution is performed through eluent, and effluent is collected; the effluent containing the product is merged; concentrating and solvent removing are performed on the merged effluent, and vacuum drying is performed to obtain the target product. The preparation method and the purification method have the advantages of being simple in technological process, low in cost and high in yield.
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Description

technical field

[0001] The invention belongs to the field of organic compounds, in particular to a preparation method of trifluoromethyl-benzothiophene derivatives. Background technique

[0002] Benzothiophene (BT) and its derivatives are important components of heterocyclic compounds. It is generally aromatic and has high stability. It is a kind of organic sulfur that is difficult to remove, and occupies a pivotal position in the research of petroleum desulfurization. At the same time, they have various reactivity, are important organic synthesis intermediates, and have important applications in the fields of pesticides, medicines, and dyes.

[0003] At present, benzothiophene derivatives are academic research hotspots. Through retrieval, Organic Chemical Impurities 1995, 15, 245-251 reported "Synthesis of 6-trifluoromethyl benzothiophene derivatives", but the process has the following disadvantages: process flow Complexity, high raw material price, high production cost, ...

Claims

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