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Osteon myospalacem Baileyi compound extract tablet with pain-easing effect and preparation method of osteon myospalacem Baileyi compound extract tablet

A composite extract and composite extraction technology, applied to medical preparations containing active ingredients, non-central analgesics, anti-inflammatory agents, etc., can solve the problems of weak disintegration and low bioavailability, and achieve the goal of overcoming disintegration weak decomposing effect, high bioavailability and simple preparation process

Inactive Publication Date: 2016-04-27
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The second object of the present invention is to provide a preparation method of the said Sialon bone compound extract tablet with analgesic effect, which overcomes the weak disintegration effect or disintegration when only adding disintegrants internally or externally. It has the disadvantage of low bioavailability due to not being fine powder after solution, and the preparation process is simple and easy to operate, which is suitable for large-scale production

Method used

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  • Osteon myospalacem Baileyi compound extract tablet with pain-easing effect and preparation method of osteon myospalacem Baileyi compound extract tablet
  • Osteon myospalacem Baileyi compound extract tablet with pain-easing effect and preparation method of osteon myospalacem Baileyi compound extract tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A preparation method of Sialon bone composite extract tablet with analgesic effect:

[0047] Raw materials: In parts by mass, 900 parts of Sialon bone compound extract, 50 parts of maltodextrin, 10 parts of starch, 20 parts of microcrystalline cellulose, 10 parts of silicon dioxide, 10 parts of magnesium stearate, xylitol 10 parts of anhydride monooleate and 10 parts of carrageenan.

[0048] Preparation method:

[0049] a) Parts by mass (300 parts of Sialon bone water extract, 100 parts of Sialon bone n-butanol extract, 200 parts of Sialon bone ethanol extract, 150 parts of Sialon bone methanol extract, Sialon bone acetate ethyl acetate 150 parts of ester extract) to prepare the Sialon bone composite extract;

[0050] b) Weigh the prescription amount of Sialon bone compound extract, crush it, pass through a 100-mesh sieve, and set aside;

[0051] c) Weigh the prescribed amount of maltodextrin and xylitol monooleate, grind, and add the Sialon bone composite extract of step a) wh...

Embodiment 2

[0057] A preparation method of Sialon bone composite extract tablet with analgesic effect:

[0058] Raw materials: In parts by mass, 800 parts of Sialon bone compound extract, 40 parts of maltodextrin, 6 parts of starch, 4 parts of mannitol, 10 parts of sodium carboxymethyl starch, 4009 parts of polyethylene glycol, xylitol 8 parts of anhydride monooleate.

[0059] Preparation method:

[0060] a) Parts by mass (300 parts of Sialon bone water extract, 100 parts of Sialon bone n-butanol extract, 100 parts of Sialon bone ethanol extract, 150 parts of Sialon bone methanol extract, Sialon bone acetate ethyl acetate 150 parts of ester extract) to prepare the Sialon bone composite extract;

[0061] b) Weigh the prescription amount of Sialon bone composite extract, crush it, pass through an 80-mesh sieve, and set aside;

[0062] c) Weigh the prescribed amount of maltodextrin and xylitol monooleate, grind, and add the Sialon bone composite extract of step a) while grinding, and continue to gri...

Embodiment 3

[0068] A preparation method of Sialon bone composite extract tablet with analgesic effect:

[0069] Raw materials: based on parts by mass, 900 parts of Sialon bone composite extract, 50 parts of maltodextrin, 10 parts of starch, 20 parts of microcrystalline cellulose, 10 parts of silicon dioxide, and 10 parts of magnesium stearate.

[0070] Preparation method:

[0071] a) Parts by mass (500 parts of Sialon bone water extract, 50 parts of Sialon bone n-butanol extract, 50 parts of Sialon bone ethanol extract, 150 parts of Sialon bone methanol extract, Sialon bone acetate ethyl acetate 150 parts of ester extract) to prepare the Sialon bone composite extract;

[0072] b) Weigh the prescription amount of Sialon bone compound extract, crush it, pass through a 100-mesh sieve, and set aside;

[0073] c) Weigh the prescribed amount of maltodextrin, grind, and add the Sialon bone composite extract of step a) while grinding, and continue grinding to win the ground;

[0074] d) Grind the starch of...

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Abstract

The invention provides an osteon myospalacem Baileyi compound extract tablet with a pain-easing effect and a preparation method of the osteon myospalacem Baileyi compound extract tablet. The osteon myospalacem Baileyi compound extract tablet is mainly prepared from osteon myospalacem Baileyi compound extract, maltodextrin, a filling agent, a disintegrating agent, a lubricating agent and the like with specific use amounts as raw materials. The osteon myospalacem Baileyi compound extract tablet has the advantages that the use amount of auxiliary materials is low, the osteon myospalacem Baileyi compound extract is uniform in dispersion, the tablet is good in disintegrating property, the efficacies are good, the pain-easing effect is obvious, the stability is good, the bioavailability is high, and the like. According to the preparation method of the osteon myospalacem Baileyi compound extract tablet, a specific material adding step is added, so that the osteon myospalacem Baileyi compound extract is uniform in dispersion, further, the efficacies of the obtained osteon myospalacem Baileyi compound extract tablet with the pain-easing effect are promoted, and the bioavailability is promoted; in addition, the defect that when the disintegrating agent is only internally added and externally added, the disintegrating function is poor, or fine powder shape can not be formed after disintegrating, and consequently, the bioavailability is low, is overcome, and moreover, the preparation technology is simple, easy to operate, and suitable for mass production.

Description

Technical field [0001] The invention relates to the technical field of Chinese patent medicines, in particular to a Sialon bone composite extract tablet with analgesic effect and a preparation method thereof. Background technique [0002] Pain is an unpleasant sensation that people often encounter in their lives. It provides a warning signal that the body is threatened. It is a special protective function that is indispensable to life. On the other hand, it is the most common symptom of various diseases and is also today. One of the most serious problems plaguing human health. From the perspective of the world today, pain has become one of the main "killers" that endanger human health, and it is also the most common and direct factor that causes the reduction of people's labor capacity and attendance. Analgesic drugs are a class of substances that can relieve the pain of diseases. They can not only selectively reduce or relieve pain, but also relieve unpleasant emotions such as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/32A61K9/20A61P29/00
CPCA61K35/32A61K9/2059
Inventor 江磊陶燕铎梅丽娟邵贇于瑞涛
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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