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Anti-depression and anti-anxiety use of Qing'e Fang extract

An extract, anti-anxiety technology, applied in the field of anti-depression and anti-anxiety use of Qing'e Fang extract

Active Publication Date: 2021-02-02
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention relates to the preparation of Qing'e Fang extract and its antidepressant and anti-anxiety effects and efficacy, and no related reports have been seen

Method used

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  • Anti-depression and anti-anxiety use of Qing'e Fang extract
  • Anti-depression and anti-anxiety use of Qing'e Fang extract
  • Anti-depression and anti-anxiety use of Qing'e Fang extract

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0079] Experimental example 1 The improving effect of the mouse olfactory bulb damage model caused by Qing'e pill of the present invention

[0080] (1) Experimental drugs and instruments

[0081] Drug: fluoxetine hydrochloride (also known as Prozac), batch number 2076A, produced by Fatheon France. Venlafaxine, lot number 1308025, manufactured by Pfizer Iretand Pharmaceuticals. Isoflurane, r-aminobutyric acid (GABA), glutamic acid (Glu), 5-hydroxytryptamine (5-HT) 5-HT, epinephrine (Epi), dopamine (DA) DA, norepinephrine (NE ) NE, 5-hydroxyindoleacetic acid (5-HIAA), 3,4-dihydroxybenzylamine (internal standard) are all products of Sigma Company.

[0082] Instrument: "Doctor Mouse" animal behavior analysis: elevated plus maze (RD1108-EPM-M), forced swimming test analysis system model (RD1119-FST-M), tail suspension test analysis system model (RD1118-TST-M), Open field test analysis system (RD1112-OFT-M). Anesthesia machine: (SNMSSN5374.UK), electric bone drill (BJ1102SAO), "...

Embodiment 1

[0154] Embodiment 1: Qing'e side extract 1

[0155] Eucommia (stir-fried with salt) 480 grams, psoralen (stir-fried with salt) 240 grams, walnut kernels (stir-fried) 150 grams, garlic 120 grams

[0156] The above medicinal materials were taken according to the above proportions, 8 times the volume of 75% ethanol was refluxed and extracted 3 times, each time for 1.5 hours, and the solvent was recovered under reduced pressure to obtain Qing'efang extract 1.

Embodiment 2

[0157] Embodiment 2: Qing'e side extract 2

[0158] Eucommia (stir-fried with salt) 480 grams, psoralen (stir-fried with salt) 240 grams, walnut kernels (stir-fried) 150 grams, garlic 120 grams

[0159] Take 480g of eucommia decoction pieces fried with salt according to the above ratio, and use 8 times the volume of petroleum ether, ethyl acetate, and ethanol in turn to extract 3 times under reflux, each extraction for 1.5 hours, mix the above extracts, and recover the solvent under reduced pressure to obtain the eucommia extract thing;

[0160] Stir-fry psoralen 240g with salt, sequentially use 8 times the volume of petroleum ether, ethyl acetate, and ethanol, and extract each under reflux for 3 times, each time for 1.5 hours, mix the above extracts, recover the solvent under reduced pressure, and obtain psoralen extract thing;

[0161] Take 150 g of fried peach kernels, sequentially use 8 times the volume of petroleum ether, ethyl acetate, and ethanol, and extract each und...

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Abstract

The invention discloses the use of Qing'e Fang extract in preparing antidepressant and anti-anxiety compositions. Oral administration of Qing'efang extract can increase the total distance of the experimental animals' activities in the field, reduce the immobility time of the tail, increase the time to open the arms in the elevated plus maze, and reduce the immobility time of forced swimming, showing better antidepressant and antidepressant effects. Anxiety effect.

Description

technical field [0001] The invention relates to a new application of Qing'e Fang extract in preparing products and / or medicines for treating or alleviating depression and anxiety. [0002] technical background [0003] The current incidence of depression in China is about 4%. According to the statistics of the World Health Organization, depression has become the fourth largest disease in the world, and it is estimated that by 2020, it may become the second largest disease after coronary heart disease. Depression not only brings mental loss to patients, but also causes heavy economic burden to patients. The total economic burden caused by depression in China reaches 62.2 billion yuan, and the annual economic loss caused by depression in the United States reaches 43.7 billion US dollars. A joint study by the World Health Organization, the World Bank and Harvard University shows that depression has become the second largest disease burden in China. [0004] Depression is asso...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8962A61P25/24A61P25/22
Inventor 王峥涛胡芳弟张紫佳吴晓俊陈文霞
Owner SHANGHAI UNIV OF T C M
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