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Cetirizine hydrochloride gel as well as preparation method and application thereof

A technology of cetirizine hydrochloride and diazine gel, which is applied in the field of medicine, can solve the problems of affecting bioavailability and reducing the biological activity of cetirizine, and achieve the effects of easy quality, rapid action and fast drug release

Inactive Publication Date: 2016-06-15
昆明市第一人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This invention adopts the method of adding alkalizing agent to improve stability, yet, the reaction of basic compound and hydrochloric acid causes the biological activity of cetirizine to reduce, affects its bioavailability

Method used

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  • Cetirizine hydrochloride gel as well as preparation method and application thereof
  • Cetirizine hydrochloride gel as well as preparation method and application thereof
  • Cetirizine hydrochloride gel as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] The preparation of embodiment 1 cetirizine hydrochloride gel

[0035] prescription:

[0036]

[0037] Preparation Process:

[0038] Prepare Carbomer-940 into a solution with a concentration of 4% and let it stand overnight to make it fully swell; take an appropriate amount of purified water, dissolve propylene glycol, add it to the above Carbomer solution and mix evenly, then add triethanolamine while stirring to make Gel-forming matrix A; dissolve cetirizine hydrochloride in a small amount of purified water, add ethanol, slowly add it to A while stirring, and finally add purified water to a sufficient amount, and stir well to obtain.

Embodiment 2

[0039] The preparation of embodiment 2 cetirizine hydrochloride gel

[0040] prescription:

[0041]

[0042]

[0043] Preparation Process:

[0044] Prepare Carbomer-940 into a solution with a concentration of 4% and let it stand overnight to make it fully swell; take an appropriate amount of purified water, dissolve propylene glycol, add it to the above Carbomer solution and mix evenly, then add triethanolamine while stirring to make Gel-forming matrix A; dissolve cetirizine hydrochloride in a small amount of purified water, add ethanol, slowly add it to A while stirring, and finally add purified water to a sufficient amount, and stir well to obtain.

Embodiment 3

[0046] prescription:

[0047]

[0048] Preparation Process:

[0049] Prepare Carbomer-940 into a solution with a concentration of 4% and let it stand overnight to make it fully swell; take an appropriate amount of purified water, dissolve propylene glycol, add it to the above Carbomer solution and mix evenly, then add triethanolamine while stirring to make Gel-forming matrix A; dissolve cetirizine hydrochloride in a small amount of purified water, add ethanol, slowly add it to A while stirring, and finally add purified water to a sufficient amount, and stir well to obtain.

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Abstract

The invention discloses a cetirizine hydrochloride gel, a preparation method and application thereof, and comprises the following components measured in 100 g: cetirizine hydrochloride 0.5-2 g, 95% ethanol 15-25 g, propylene glycol 5-15 g, Triethanolamine 0.5-2.5g, Carbomer-940 0.5-2g, pure water to make up the balance. It is prepared by the following method: taking an appropriate amount of purified water, dissolving propylene glycol, adding the prepared carbomer solution and mixing evenly, adding triethanolamine while stirring to form a gel matrix A; dissolving cetirizine hydrochloride in After adding a small amount of purified water, add ethanol, slowly add it to A under stirring, and finally add purified water to a sufficient amount, stir well, and that’s it. The gel preparation of the present invention has a significant effect on treating skin allergy and allergic rhinitis, and has the advantages of better stability, less impurity generation, longer validity period, convenient transportation and storage, and less potential adverse reactions.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a cetirizine hydrochloride gel and its preparation method and application. Background technique [0002] Cetirizine hydrochloride (cetirizinehydrochloride), chemical name: (±)-2-[2-[4-[(4-chlorophenyl)benzyl]-1-piperazinyl]ethoxy]acetic acid disalt salt, molecular formula: C 21 h 25 ClN 2 o 3 2HCl; molecular weight: 461.81; chemical structural formula as follows: [0003] [0004] Cetirizine hydrochloride is a potent H1 receptor antagonist. It is orally administered into the body and quickly binds to the histamine H1 receptor on the target cell membrane, blocking the activation of target cells by histamine. Cetirizine has no obvious anticholinergic and anti-serotonin effects. In normal doses, it is difficult to pass through the blood-brain barrier. It can inhibit the transmission of histamine in the early stage of allergic reaction, reduce the migratory act...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/495A61K47/32A61P37/08A61P11/02A61P17/00
CPCA61K9/06A61K31/495A61K47/32
Inventor 李兴德宋沧桑田静包金颖
Owner 昆明市第一人民医院
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