Preparation method of high-purity and low-chroma gemfibrozil

Abstract

The invention discloses a high-purity low-chroma gemfibrozil preparation method. The method comprises 1, preparing a gemfibrozil isobutyl ester crude product and can also comprises 2, adding an alkali liquor II in the gemfibrozil isobutyl ester crude product until the system pH is in a range of 10.0-12 and carrying out reduced pressure rectification to obtain gemfibrozil isobutyl ester, 3, carrying out reflux alkaline hydrolysis on the gemfibrozil isobutyl ester and carrying out acid adjustment to obtain a gemfibrozil crude product, and 4, refining the gemfibrozil crude product through adding an alcohol-water solution into the gemfibrozil crude product, carrying out heating reflux, carrying out heat preservation for 0.5-1h, carrying out cooling to a temperature of 0-5 DEG C, carrying out thermal insulation stirring for 1.5-2.5h, carrying out filtration to obtain filter cake and drying the filter cake to obtain high-purity low-chroma gemfibrozil.

Description

technical field

[0001] The invention relates to a preparation method of gemfibrozil with high purity and chromaticity, which belongs to the technical field of medicinal chemistry, and specifically relates to a gemfibrozil with a pure white color, a liquid-phase normalized content of more than 99.9%, and a chromaticity of less than 3.0. The preparation method of gemfibrozil, so that gemfibrozil will not turn red and change color when stored for a long time. Background technique

[0002] Gemfibrozil, the chemical name is 2,2-dimethyl-5-(2,5-dimethylphenyloxy)-pentanoic acid, the English name is 5-(2,5-dimethylphenoxy)-2 ,2-dimethylpentanoic acid, the structural formula is as follows:

[0003]

[0004] Gemfibrozil is a clofibrate blood lipid regulating drug, used for hyperlipidemia, stable drug effect, low adverse reaction rate, high safety, can be taken for a long time, and can prevent arteriosclerosis and help reduce myocardial infarction morbidity. It was launched in t...

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