Preparation and application of a polyethylene glycol functionalized magnetic carbon nanotube

A technology of magnetic carbon nanotubes and polyethylene glycol, applied in chemical instruments and methods, other chemical processes, chemical/physical processes, etc., can solve the problems of high hydrophobicity and poor biocompatibility on the surface of carbon nanotubes, and achieve rapid The effects of separation and enrichment, stable properties and long storage time

Active Publication Date: 2018-03-06
CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the deficiencies of the prior art, to provide a method for preparing polyethylene glycol functionalized magnetic carbon nanotube composite material, the preparation method is simple, easy to industrial production, can be repeatedly used, saving economic costs, The composite material effectively solves the problems of high hydrophobicity and poor biocompatibility on the surface of existing carbon nanotubes, combined with the superparamagnetism of magnetic nanoparticles, it is firstly used in the separation and quality control of active small molecules in traditional Chinese medicine extracts, and can be conveniently , rapid, efficient and specific separation of Z-ligustilide

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  • Preparation and application of a polyethylene glycol functionalized magnetic carbon nanotube
  • Preparation and application of a polyethylene glycol functionalized magnetic carbon nanotube
  • Preparation and application of a polyethylene glycol functionalized magnetic carbon nanotube

Examples

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Embodiment 1

[0033] Example 1: Preparation method of polyethylene glycol functionalized magnetic carbon nanotube composite material

[0034] (1) Weigh 400mg of the original carbon nanotubes and disperse them in 50mL of 65-68% concentrated nitric acid, and react with magnetic stirring at 60°C for 7 hours. Use a microporous membrane with a pore size of 0.45um to filter through a Buchner funnel and continuously wash with distilled water until pH=7, vacuum drying at 50°C to obtain carboxylated multi-walled carbon nanotubes (CNTs-COOH);

[0035] (2) Take 150mg CNTs-COOH and 810mg FeCl of the above oxidized carbon nanotubes 3 Disperse in 40-50mL polyethylene glycol containing trisodium citrate (150mg), sodium acetate (3.6g) and polyethylene glycol 2000 (1.0g), and ultrasonically disperse, the ultrasonic dispersion time is 2h; transfer the liquid Into the reaction kettle, heat to 200 for reaction 10, wash with water and ethanol, and freeze-dry to obtain magnetic carbon nano (CNTs-COOH-MNP);

[0036] (3...

Embodiment 2

[0037] Example 2: Preparation method of polyethylene glycol functionalized magnetic carbon nanotube composite material

[0038] (1) Weigh 400mg of original carbon nanotubes and disperse them in 50mL 65-68% concentrated nitric acid, and react with magnetic stirring at 60°C for 7 hours. Use a 0.45um microporous filter membrane to filter through a Buchner funnel and continuously wash with distilled water Dry under vacuum until pH=7 at 50°C to obtain oxidized multi-walled carbon nanotubes (CNTs-COOH);

[0039] (2) Take 150mg CNTs-COOH and 1g FeCl of the above oxidized carbon nanotubes 3 Disperse in 40-50mL polyethylene glycol containing trisodium citrate (150mg), sodium acetate (3.6g) and polyethylene glycol 2000 (1.0g), and ultrasonically disperse, the ultrasonic dispersion time is 2h; transfer the liquid Into the reaction kettle, heat to 200 for reaction 10, wash with water and ethanol, and freeze-dry to obtain magnetic carbon nano (CNTs-COOH-MNP);

[0040] (3) Weigh 80 mg of magnetic...

Embodiment 3

[0041] Example 3: Polyethylene glycol functionalized magnetic carbon nanotube composite material is used as a dispersive solid phase extraction adsorbent for the separation of active small molecules of Angelica sinensis and the quality control of Angelica sinensis:

[0042] The standard sample of Z-ligustilide was purchased from Chengdu Munster Biotechnology Co., Ltd., and the mass concentration of Z-ligustilide was 0.625-7.5ug / mL prepared with methanol (the Z-ligustilide concentration was 0.625, 1.25, 2.50, 5.00, 7.50) -Ligustilide standard sample solution) Z-ligustilide standard sample solution for HPLC determination, the specific experimental process is as follows: prepare Z-ligustrum with mass concentrations of 0.625, 1.25, 2.50, 5.00, 7.50 with methanol The standard sample solution of this lactone is measured by HPLC (the instrument model is LC-20AD, the manufacturer is Shimadzu Corporation, and the instrument is equipped with Tianhe C18 column (250×4.6mm, 5um particle size);...

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Abstract

The invention relates to the preparation and application of polyethylene glycol functionalized magnetic carbon nanotubes. The method is that carbon nanotubes are added to nitric acid solution, magnetically stirred for reaction, diluted with water, dried, placed in a mixed solution of ethylene glycol, ferric salt, sodium citrate, sodium acetate and polyethylene glycol, and ultrasonically placed in a reaction kettle react to obtain carbon nanotube derivatives supported by ferroferric oxide; react with aminated polyethylene glycol substances, EDC and NHS to obtain polyethylene glycol covalently modified magnetic carbon nanotube composite materials. The polyethylene glycol-functionalized magnetic carbon nanotubes of the present invention show good dispersibility and stability as a dispersed solid-phase extraction adsorbent, act on Z-ligustilide with high selectivity, and can realize rapid preparation of pure Higher quality control of Z-ligustilide and related traditional Chinese medicines and preparations; the method for preparing composite materials in the present invention is simple to operate, convenient to prepare, low in cost, and suitable for industrialized large-scale production.

Description

Technical field [0001] The invention belongs to the field of functional materials and separation technology, in particular to a preparation method of polyethylene glycol functionalized magnetic carbon nanotube composite material and its use as a dispersed magnetic solid phase extraction adsorbent in the preparation of active small molecules of traditional Chinese medicine and the quality control of traditional Chinese medicine The application in Chinese medicine is specifically the separation and extraction of Z-ligustilide from Chinese medicines Angelica, Chuanxiong and Ligusticum chinense. Background technique [0002] Traditional Chinese medicine has become more and more popular in the treatment of diseases due to its small side effects, so the identification of their active ingredients and quality control analysis have become very important. People often select some "chemically labeled molecules" for the quantitative and qualitative analysis of traditional Chinese medicine. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/20B01J20/281B01J20/30B01D15/08
CPCB01D15/08B01J20/205B01J20/28009B01J20/281B01J2220/4806B01J2220/54
Inventor 廖循曾琼
Owner CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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