Preparation method of temperature-sensitive liquid embolic material for long-term development in situ gelation

Abstract

The invention relates to the technical field of vessel embolus development materials in biomedical engineering, particularly a preparation method of an in-situ-gelation temperature-sensitive liquid embolic material capable of development for a long time. The preparation method comprises the following steps: carrying out recrystallization treatment on N-isopropyl acrylamide, and carrying out reaction on the recrystallized N-isopropyl acrylamide, butyl methacrylate and an iodine-containing monomer by adding an initiator and a crosslinking agent, thereby obtaining a temperature-sensitive copolymer; and repeatedly washing the temperature-sensitive copolymer in water, purifying, drying, dissolving the dried product in water for injection, and sterilizing, thereby obtaining the in-situ-gelation temperature-sensitive liquid embolic material. The development functional group is copolymerized with the isopropyl acrylamide and butyl methacrylate through the unsaturated monomer, and thus, the obtained polymer has the development characteristic. The iodine-containing part can not be lost due to the flow of the normal saline, body fluid and blood; and thus, the in-situ-gelation temperature-sensitive liquid embolic material performs the permanent embolism function, is a permanent-development embolic agent, can achieve the effect of long-term development, is convenient for reinspection, and reduces the economic burden of the patients.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering vascular embolism imaging materials, in particular to a preparation method of an in-situ gelling temperature-sensitive liquid embolism material that can be developed for a long time. Background technique [0002] Transcatheter embolization is an important technique in interventional radiology. It uses different types of catheters to inject embolic materials into the blood supply vessels or lesions in a controlled manner, so that they can be blocked and interrupt the blood supply, so as to control bleeding, treat vascular lesions, treat tumors, and eliminate diseased organs. Purpose. [0003] Embolization materials play a key role in the success of transcatheter embolization. At present, most embolization materials that have been used in clinics use temporary external contrast agents, such as tantalum powders, which are prone to incomplete embedding, and non-ionic contrast agents c...

AI Technical Summary

Problems solved by technology

[0009] In order to solve the above problems in the prior art that the mixed developer is easy to lose, cause high diagnosis cost, and the reactive developer has potential safety hazards, this application provides a safe and reliable reactive long-term developing in-situ gelation temperature sensitive Preparation method of type liquid embolic material

Images