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Medical polyvinyl alcohol gel and preparing method thereof

A polyvinyl alcohol gel, polyvinyl alcohol technology, applied in the field of medical devices, can solve problems such as insufficient capacity, and achieve the effect of avoiding toxicity and enhancing biocompatibility

Inactive Publication Date: 2016-06-22
袁暾
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When used as a radiation protection gel, although the gel has a certain ability to block rays, this ability is still insufficient.

Method used

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  • Medical polyvinyl alcohol gel and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Weigh 0.29g of boric acid and 0.1g of borax, fully dissolve it with 100mL of 0.9% sodium chloride solution, add 6g of polyvinyl alcohol and 1g of polyethylene glycol, mix thoroughly again, and heat up to 121°C for 60 minutes . After cooling down, construct the gel through 20 repeated freeze-thaw cycles from -20°C to 37-20°C, fully wash the constructed gel with sterile saline, and then apply the obtained stable gel to the burn wound Apply repair.

Embodiment 2

[0022] Weigh 12.6g of boric acid and 1.0g of borax, fully dissolve them in 100mL of double distilled water, add 12g of polyvinyl alcohol and 0.5g of cerium sulfate, mix well again, and heat up to 121°C for 30 minutes. After cooling down, the gel is constructed through repeated freeze-thaw dehydration, and then the obtained stable gel is used for the application of radiation-proof medical devices.

Embodiment 3

[0024] Weigh 5g of boric acid and 0.5g of borax, fully dissolve them in 100mL of double distilled water, add 10g of polyvinyl alcohol, 1.0mL of ethanol and 10mL of glycerin, mix well again, then raise the temperature to 121°C for 30 minutes. After cooling down, the gel is constructed by repeated freeze-thaw and irradiation treatments, and then the obtained stable gel is used for local cold compress medical devices.

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Abstract

The invention relates to medical polyvinyl alcohol gel for filling, repairing, application and radiation protection. A preparing method is characterized by including the steps that a cross-linking system is jointly constructed through boric acid in a certain proportion and boraxin a certain proportion, the boric acid and the boraxin are fully dissolved, polyvinyl alcohol is added, the mixture is mixed to be even to be subjected to heating and heat preservation, and the gel is constructed in one or more physical modes. On the basis, 0.9% of sodium chloride is used for reducing the toxicity of the cross-linking system, and blended or copolymerized atactic polyvinyl alcohol, intermittent polyvinyl alcohol and block polyvinyl alcohol are used; monomer alcohol, alkane and aldehyde are added; glycerol is added; the mode that rare earth elements and natural polymers are added is used for adjusting the performance of a gel system and allowing the gel system to meet the requirements of prospective applications of different medical apparatus and instruments. By means of the medical polyvinyl alcohol and the preparing method, the better cross-linking effect, the lower and more controllable toxicity of a cross-linking agent, the better cold accumulation performance and the better radiation protection performance can be provided, biocompatibility is excellent, and the boric acid-boraxin cross-linkage polyvinyl alcohol gel system is can be easily improved in the following process.

Description

technical field [0001] The invention relates to a medical device, in particular to a medical polyvinyl alcohol gel used for filling, repairing, applying and radiation protection. The gel can be used in implants, wound repair, cold compress and radiation protection devices . Background technique [0002] Many natural and synthetic polymer materials can form gels under suitable conditions. Some gel materials can be used for medical purposes due to their good physical, chemical and biological properties. Among them, because of its lower cost, relatively simple gelation process, and relatively easy-to-control gel properties, polyvinyl alcohol gel has received extensive attention. Based on polyvinyl alcohol gel, it is used for implantation and tissue engineering. and cold compress equipment have been reported. However, there are still obvious deficiencies in the effectiveness, safety and quality controllability of the existing polyvinyl alcohol gel when used as a medical devic...

Claims

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Application Information

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IPC IPC(8): C08L29/04C08L71/02C08L89/00C08L5/08C08K3/38C08K3/30C08K13/02C08K5/05C08K5/053C08J3/075A61L15/24A61L15/42A61L27/16A61L27/52
CPCC08L29/04A61L15/24A61L15/42A61L27/16A61L27/52A61L2300/412A61L2430/06C08J3/075C08J2329/04C08K3/30C08K3/38C08K5/05C08K5/053C08K13/02C08K2003/3045C08K2201/014C08L2205/03C08L71/02C08K2003/387C08L89/00C08L5/08
Inventor 袁暾
Owner 袁暾
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