Method for synthesizing calcium epoxysuccinate suspension and method for producing l‑(+)‑tartaric acid

Abstract

The invention discloses a method for synthesizing cis-epoxy calcium succinate. The method uses maleic anhydride, calcium carbonate and hydrogen peroxide to react under the catalysis of sodium tungstate, and then uses calcium hydroxide to adjust the pH. The invention also discloses a method for producing L-(+)-tartaric acid, wherein cis-epoxysuccinate calcium utilizes enzyme catalysis to produce L-(+)-calcium tartrate, and the solid L-(+) ‑Calcium tartrate crude product, then hydrolyzed with sulfuric acid, then separated to remove calcium sulfate, and then purified to obtain the final product L‑(+)‑tartaric acid. The present invention can replace the current conversion process of cis-epoxysodium sodium succinate, directly generate L-(+)-calcium tartrate, save the calcium salt precipitation operation unit, reduce the emission of sodium ions at the same time, reduce the consumption of raw materials, and have significant advantages Industrial application value and environmental benefits.

Description

technical field [0001] The invention belongs to the field of biocatalytic preparation of organic acids, in particular to a method for synthesizing calcium epoxysuccinate suspension and a method for producing L-(+)-tartaric acid using the suspension. Background technique [0002] L-(+)-tartaric acid is a natural organic acid, which is an important food additive and chemical raw material. The traditional enzymatic conversion to produce L-(+)-tartaric acid generally uses cis-epoxysuccinate sodium as the catalytic substrate, and under the catalysis of cis-epoxysuccinate hydrolase (ESH), L-(+) -sodium tartrate, and then use the calcium salt method to extract L-(+)-tartaric acid (that is, add a calcium neutralizer to the conversion solution containing L-(+)-sodium tartrate to generate L-(+)- Calcium tartrate, after repeated crystallization and washing, add sulfuric acid acid hydrolysis to extract L-(+)-tartaric acid, and decolorize with activated carbon, and remove impurity ions ...

AI Technical Summary

Problems solved by technology

In order to overcome the defects such as low batch conversion efficiency of traditional cis-calcium epoxysuccinate, the present invention adopts the mode of continuous feeding, and adds sodium sulfate co-solvent during the conversion process of cis-calcium epoxysuccinate, so that in the reaction system The various ions are in the dynamic equilibrium state of "cis-calcium epoxysuccinate-calcium sulfate-sodium cis-epoxysuccinate-sodium sulfate", thereby improving the conversion efficiency of calcium cis-epoxysuccinate and L-( +)-Tartaric acid production efficiency

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