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A kind of Huang alone element b dispersible tablet and preparation method thereof

A technology of flavonoids and dispersible tablets, applied in the field of medicine, can solve the problems of poor water solubility, reduced inhibitory effect, low cross-resistance, etc., and achieves good stability, increased disintegration rate and dissolution, and less adverse reactions.

Active Publication Date: 2018-06-12
SHANDONG ACAD OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Flatin B has a dose-dependent anti-tumor effect in the range of 2-16 mg / kg, and has no significant toxicity. Flavor B has obvious inhibitory effect on the proliferation and metastasis of gastric cancer cell SGC-7901, and Flatin B shows SGC -7901 has low cross-resistance, which overcomes the disadvantages of chemotherapy drugs with the same mechanism of action that the inhibitory effect of other chemotherapy drugs on the tumor will be reduced to a certain extent after the tumor becomes resistant to a certain chemotherapeutic drug
However, due to its poor water solubility and low bioavailability, its development and application are limited, and the preparations related to lutein B have not been marketed at home and abroad.

Method used

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  • A kind of Huang alone element b dispersible tablet and preparation method thereof
  • A kind of Huang alone element b dispersible tablet and preparation method thereof
  • A kind of Huang alone element b dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Weigh 2.5g of lutein B, 20g of microcrystalline cellulose, 70.5g of cellulose lactose, 5.0g of cross-linked sodium hydroxymethyl starch, and 2g of micropowdered silica gel according to the weight ratio, and grind them separately, and pass through 100 meshes sieve, spare;

[0023] (2) Mix 2.5g of luteolin B, 20g of microcrystalline cellulose, 70.5g of cellulose lactose, and 2.5g of cross-linked hydroxymethyl starch sodium in equal increments, add 4g of soft material made of 70% ethanol, and pass Granulate with a 20-mesh sieve, dry in an oven at 55°C to constant weight, pass through a 20-mesh sieve for granulation;

[0024] (3) Then add micropowder silica gel and 2.5g cross-linked sodium hydroxymethyl starch, mix well, and press into tablets to obtain dispersible tablets, each weighing 0.20±0.01g.

Embodiment 2

[0026] (1) Weigh 2.5% of lutein B, 20% of microcrystalline cellulose, 70.5% of cellulose lactose, 5.0% of cross-linked sodium hydroxymethyl starch, and 2% of micropowdered silica gel in proportion by weight, and grind them separately, and pass through 100 Mesh sieve, spare;

[0027] (2) Mix luteolin B, microcrystalline cellulose, cellulose lactose, and 3.75% cross-linked hydroxymethyl starch sodium in equal increments, and add 70% ethanol containing 6% of the total mass of traditional Chinese medicine in step (1). For soft materials, pass through a 20-mesh sieve to granulate, dry in an oven at 60°C until constant weight, pass through a 20-mesh sieve to granulate;

[0028] (3) Then add micropowder silica gel and the remaining 1.25% of cross-linked sodium hydroxymethyl starch, mix well, and press into tablets to obtain dispersible tablets, each weighing 0.20±0.01g.

Embodiment 3

[0030] A yellow sole B dispersible tablet, the raw material composition is: 2.5% yellow sole B, 20% microcrystalline cellulose, 65.5% cellulose lactose, 10% cross-linked sodium hydroxymethyl starch, 2% micropowder silica gel. The internal addition amount of cross-linked hydroxymethyl starch sodium is 6.0%, and the external addition amount is 4.0%.

[0031] The preparation method is the same as in Example 2.

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Abstract

The invention relates to diosbulbin B dispersible tablets. The diosbulbin B dispersible tablets are prepared from, in percentage by weight, 2.5%-5.0% of diosbulbin B, 5%-15% of disintegrating agent crosslinked sodium carboxymethyl starch, 0.5%-3.0% of wetting agent superfine silica powder, 20%-40% of microcrystalline cellulose and the balance of cellulose lactose. Meanwhile, the invention also relates to a preparation method of the diosbulbin B dispersible tablets. A wet granulation method is adopted, the disintegrating agent is injected with an interior and exterior addition method, 1 / 2-3 / 4 of diosbulbin B, microcrystalline cellulose, cellulose lactose and crosslinked sodium carboxymethyl starch by mass are mixed for granulation, the superfine silica powder and the remaining crosslinked sodium carboxymethyl starch are added and subjected to tableting, and the dispersible tablets are prepared. The bioavailability of the diosbulbin B is improved, the medicine disintegration speed and the dissolution rate are increased, few adverse reactions are caused, and better stability is realized.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a dispersible tablet of yellow sole B and a preparation method thereof. Background technique [0002] Huangyaozi is the tuber of Dioscorea genus Dioscorea in the Dioscoreaceae family. It has the effects of dispelling stagnation and eliminating galls, detoxifying, reducing swelling, cooling blood and stopping bleeding. It is mostly used clinically to treat various cancers, goiter, cough and asthma, etc. Fenugreek also has antiviral and antibacterial effects. Clinically, it is often compatible with angelica to increase the anti-tumor effect of xanthophyll by reducing the expression of P-glycoprotein. [0003] Xanthophyllin B is an important part of the diterpene lactones in Xanthophyllum officinalis. Flatin B has a dose-dependent anti-tumor effect in the range of 2-16 mg / kg, and has no significant toxicity. Flavor B has obvious inhibitory effect on the proliferation...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/365A61K47/36A61K47/38A61K47/04A61P35/00A61P35/04
CPCA61K9/2009A61K9/2054A61K9/2059A61K31/365
Inventor 闫雪生王平于蓓蓓孙丹丹徐新刚张丹丹
Owner SHANDONG ACAD OF CHINESE MEDICINE
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