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Preparation method for cimicifuga dahuria throat-clearing buccal tablet

A technology for clearing throat and powder, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc. It can solve the problems of production process steps that induce dental caries, common excipients adhere to teeth and gums, and incomplete release of active ingredients. , to achieve the effect of avoiding the induction of dental caries, refreshing taste, good prevention and health care

Inactive Publication Date: 2016-08-10
哈药集团中药二厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problem of incomplete release of active ingredients in existing Qingyan lozenge health products, low oral bioavailability, not refreshing taste, common auxiliary materials sticking to teeth and gums, inducing dental caries and too many production process steps, High energy consumption, high pollutant discharge and other problems, thus providing a preparation method of Beihema Qingyan buccal tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0022] Specific embodiment one: the preparation method of a kind of Beishengma Qingyan buccal tablet of the present embodiment, it is to carry out according to the following steps:

[0023] 1. Sieving: Take cohosh extract powder, burdock seed extract powder, Fritillaria chinensis extract powder, xylitol, erythrose

[0024] Alcohol, maltodextrin, glycyrrhizin, malic acid and peppermint powder essence passed through a 100-mesh sieve, magnesium stearate passed through a 200-mesh sieve;

[0025] 2. Weighing: Take the components sieved in step 1, and weigh them according to the following parts by mass: 60-180 parts of cohosh extract powder, 50-130 parts of burdock fruit extract powder, 30-180 parts of 90 parts of flat fritillaria extract powder, 150-350 parts of xylitol, 150-350 parts of erythritol, 100-300 parts of maltodextrin, 10-30 parts of mint powder essence, 1.0-3.0 Glycyrrhizin, 3.0-9.0 parts of malic acid, 150-400 parts of 85% ethanol solution by volume and 2.0-7.0 parts ...

specific Embodiment approach 2

[0037] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that the components described in step 2 after sieving in step 1 are weighed according to the following parts by mass: 60 to 160 parts of Beisheng Hemp extract powder, 50-120 parts of burdock fruit extract powder, 30-80 parts of flat fritillaria extract powder, 150-300 parts of xylitol, 150-300 parts of erythritol, 100-280 parts 10-28 parts of mint powder flavor, 1.0-2.8 parts of glycyrrhizin, 3.0-8.0 parts of malic acid, 150-350 parts of 85% ethanol solution by volume and 2.0-6.0 parts of part of magnesium stearate. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0038]Specific embodiment 3: The difference between this embodiment and specific embodiment 1 or 2 is that the components described in step 2 after sieving in step 1 are weighed according to the following parts by mass: 60-140 parts North cohosh extract powder, 50-110 parts of burdock seed extract powder, 30-70 parts of flat fritillaria extract powder, 150-250 parts of xylitol, 150-250 parts of erythritol, 100 parts ~240 parts of maltodextrin, 10~24 parts of peppermint powder flavor, 1.0~2.4 parts of glycyrrhizin, 3.0~7.0 parts of malic acid, 150~300 parts of 85% ethanol solution and 2.0 parts by volume -5.0 parts of magnesium stearate. Others are the same as in the first or second embodiment.

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Abstract

The invention discloses a preparation method for a cimicifuga dahuria throat-clearing buccal tablet, and relates to a preparation method for a preparation of the throat-clearing buccal tablet. The preparation method mainly solves the problem that extract of a current buccal tablet for clearing the throat prepared through a common extracting method is poor in mouthfeel under tongue while being tabletted, has a sticky feeling, and is low in bioavailability, and auxiliary materials such as saccharose and starch are easily stuck on teeth to cause decayed teeth. The preparation method for the cimicifuga dahuria throat-clearing buccal tablet comprises the following steps: I, screening raw and auxiliary materials; II, weighing the raw and auxiliary materials; III, mixing the raw materials; IV, mixing the auxiliary materials; V, mixing the raw and auxiliary materials; VI, stirring and pelletizing the raw and auxiliary materials at a high speed; VII, drying; VIII, pelletizing; IX, mixing; and X, tabletting. According to the preparation method, the cimicifuga dahuria throat-clearing buccal tablet prepared by extract prepared by adopting a semi-bionic-enzyme extraction technology is good in mouthfeel, is quick in effect-taking, is high in bioavailability under tongue, is free of a sticking feeling under tongue, is not struck on gingivae and teeth, is refreshing, and does not easily cause decayed teeth; and modern pharmaceutical equipment is adopted, so that the industrial production requirements can be met.

Description

technical field [0001] The invention relates to a preparation method of the health food Beicifuma throat-clearing buccal tablet with the function of clearing the throat. Background technique [0002] Buccal tablets have the advantages of convenient administration, high bioavailability and quick onset of action due to the absorption of some drugs through the mucous membrane without the first-pass effect of the liver. Therefore, throat-clearing health care products are mostly made into lozenges. Qingyan lozenges have the functions of clearing the throat and relieving throat discomfort. It is used for acute and chronic pharyngitis, dryness, itching, swelling and pain caused by throat fatigue, and unpleasant sputum. In recent years, air pollution such as PM2.5 and sulfur dioxide in the atmosphere has become more and more serious, and the incidence of pharyngitis has been increasing year by year. Qingyan buccal tablets protect the pharynx diseases caused by endocrine and externa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/20A61P11/04
CPCA61K36/71A61K9/0056A61K9/2059A61K36/28A61K36/8966A61K2300/00
Inventor 刘景国冯文军柳松林广鸿雁秦绪江单钰毓李殿明
Owner 哈药集团中药二厂
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