The invention belongs to the technical field of food processing, and relates to a production method of wolfberry fruit wine. The production method comprises the following steps: 1, raw material preparation: selecting fresh Chinese wolfberry fruits or dried Chinese wolfberry fruits as the raw materials, 2, pulping: pulping the raw materials to obtain a wolfberry fruit juice, 3, enzymolysis, 4, separation: separating a clarified wolfberry fruit juice and insoluble pulp, 5, ultrafiltration: carrying out ultrafiltration to obtain an ultrafiltered wolfberry fruit juice and a trapped fluid, 6, fermentation: taking the ultrafiltered wolfberry fruit juice or a mixture of the ultrafiltered wolfberry fruit juice and insoluble pulp as a fermentation raw material, and separating wine lees from a wineliquid, 7, ageing, and 8, fining, rough filtering, fine filtering and filling so that the wolfberry fruit wine is obtained. According to the production method, the content of higher alcohol formed inthe fermentation process is effectively reduced, the quality, stability and health-care functions of the wine are improved, and the comprehensive utilization rate of raw materials is increased.