Preparation method for degradable biological wound dressing and obtained product

A wound dressing and biological technology, applied in the fields of medical science, absorbent pads, bandages, etc., can solve the problems of high production cost of bacterial cellulose dressings, increased risk of organic solvent residues, not human endogenous substances, etc., to facilitate industrial production. , rich pores, easy to use effect

Active Publication Date: 2016-08-10
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This invention requires washing with ethanol solution during the process of filtering and separating the product, which increases the risk of organic solvent residue in the product, and may cause adverse effects when in contact with the wound site
Commercialized bacterial cellulose dressings are only seen in Xcell, which was launched in 2003 and produced by American Xylos, but the production cost of large-scale production of bacterial cellulose dressings is too high. In addition, although the loaded nano-silver particles have a significant bactericidal effect, they are not Human endogenous substances cannot be biodegraded, and there are certain risks in use

Method used

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  • Preparation method for degradable biological wound dressing and obtained product
  • Preparation method for degradable biological wound dressing and obtained product
  • Preparation method for degradable biological wound dressing and obtained product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] In order to investigate the effects of chitosan or its derivatives and different cellulose derivatives on the degradable biowound dressing of the present invention, several degradable biowound dressings with different compositions were simultaneously prepared in this example.

[0050] The preparation method of degradable biowound dressing is:

[0051] (1) Adjust the pH value of deionized water to 10, add 1,4-butanediol diglycidyl ether (BDDE), and mix well to obtain a mixed solution. The amount of 1,4-butanediol diglycidyl ether accounts for 1% of the total mass of sodium hyaluronate and cellulose derivatives, sodium hyaluronate and cellulose derivatives are fully dissolved in deionized water, the concentration is 5%;

[0052] (2) Sodium hyaluronate (1000kD) and sodium carboxymethyl cellulose (group A), or sodium hyaluronate (1000kD) and sodium hydroxyethyl cellulose (group B), or sodium hyaluronate (1000kD) (group C), or sodium hyaluronate (1000kD) and sodium carboxym...

Embodiment 2

[0071] In order to investigate the effect of drying method and dorsal weighing material on the degradable biowound dressing of the present invention, four kinds of degradable biowound dressings were simultaneously prepared in this embodiment.

[0072] The preparation method of degradable biowound dressing is:

[0073] (1) Adjust the pH value of deionized water to 12, add 1,4-butanediol diglycidyl ether, and mix well to obtain a mixed solution. 2% of the total mass of cellulose derivatives, sodium hyaluronate and cellulose derivatives are fully dissolved in deionized water, the concentration is 2%;

[0074] (2) Dissolve sodium hyaluronate (500kD) and sodium carboxymethylcellulose in the mixed solution, mix well and fully dissolve the biopolysaccharide, react at 30°C for alkaline cross-linking, and cross-link for 6 hours;

[0075] (3) After basic cross-linking, adjust the pH value of the reaction system to 3, carry out acidic cross-linking at 30°C, and cross-link for 10 hours; ...

Embodiment 3

[0091] In this example, 1500kD sodium hyaluronate, water-soluble chitosan, and sodium carboxymethylcellulose were used to prepare a biodegradable biowound dressing, and the dosage relationship of each component is shown in Table 3.

[0092] Table 3 composition ratio

[0093]

[0094] The preparation method is as follows:

[0095] (1) Adjust the pH value of deionized water to 11, add 1,4-butanediol diglycidyl ether, and mix well to obtain a mixed solution. Sodium hyaluronate and cellulose derivatives are fully dissolved in deionized water at a concentration of 5 %;

[0096] (2) Sodium hyaluronate and sodium carboxymethylcellulose were dissolved in the mixed solution, mixed evenly and the biopolysaccharide was fully dissolved, reacted at 35°C for alkaline cross-linking, and cross-linked for 2 hours;

[0097] (3) After alkaline crosslinking, adjust the pH value of the reaction system to 3, and carry out acidic crosslinking at 35°C for 8 hours;

[0098] (4) After alkali-acid...

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Abstract

The invention discloses a preparation method for degradable biological wound dressing and an obtained product. The preparation method comprises the following steps: first, cross-linking sodium hyaluronate and a cellulose derivative under an alkaline condition; then, cross-linking the sodium hyaluronate and the cellulose derivative under an acid condition; dialyzing, purifying and granulating the obtained cross-linked gel; uniformly mixing the cross-linked gel and chitosan aqueous solution; removing air bubbles, pouring a mixture into a mould, and drying to obtain the degradable biological wound dressing. The method disclosed by the invention is high in safety and easy and convenient to operate; a cross-linking system is prepared by one step; two-step cross-linking can be completed by only regulating the pH value; the cross-linking time is greatly shortened; industrial production is facilitated. The obtained product is high in biocompatibility and high in safety, and is suitable for liquid suction, wound protection and repair of a mild to severe seepage skin wound; secondary damage is prevented; the degradable biological wound dressing is convenient to replace and convenient to use.

Description

technical field [0001] The invention relates to a preparation method of a degradable biological wound dressing and the obtained product. The dressing is suitable for liquid absorption, wound protection and repair of mild to severe exudative skin wounds, and belongs to the technical field of wound dressings. Background technique [0002] The skin of the human body is a barrier to contact with the external environment. When skin defects are caused by factors such as trauma or disease, the water, electrolytes and protein on the wound surface are often lost. The open wound surface also increases the chance of infection. Early and effective wound closure can reduce The occurrence of complications. [0003] Wound dressings are a class of medical materials that can temporarily protect wounds, prevent infection, and promote healing. According to authoritative statistics, the world wound dressing market was valued at US$11.7 billion in 2012, and is expected to reach US$18.5 billion ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/44C08J3/24C08L5/08C08L1/28C08L5/04
CPCA61L15/28A61L15/42A61L15/44A61L2300/232A61L2300/404A61L2300/41C08J3/24C08J2301/28C08J2305/08C08J2401/28C08J2405/04C08J2405/08C08L5/08C08L1/286C08L1/284
Inventor 冯晓毅宋永民耿凤郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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