Preparation method for degradable biological wound dressing and obtained product
A wound dressing and biological technology, applied in the fields of medical science, absorbent pads, bandages, etc., can solve the problems of high production cost of bacterial cellulose dressings, increased risk of organic solvent residues, not human endogenous substances, etc., to facilitate industrial production. , rich pores, easy to use effect
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Embodiment 1
[0049] In order to investigate the effects of chitosan or its derivatives and different cellulose derivatives on the degradable biowound dressing of the present invention, several degradable biowound dressings with different compositions were simultaneously prepared in this example.
[0050] The preparation method of degradable biowound dressing is:
[0051] (1) Adjust the pH value of deionized water to 10, add 1,4-butanediol diglycidyl ether (BDDE), and mix well to obtain a mixed solution. The amount of 1,4-butanediol diglycidyl ether accounts for 1% of the total mass of sodium hyaluronate and cellulose derivatives, sodium hyaluronate and cellulose derivatives are fully dissolved in deionized water, the concentration is 5%;
[0052] (2) Sodium hyaluronate (1000kD) and sodium carboxymethyl cellulose (group A), or sodium hyaluronate (1000kD) and sodium hydroxyethyl cellulose (group B), or sodium hyaluronate (1000kD) (group C), or sodium hyaluronate (1000kD) and sodium carboxym...
Embodiment 2
[0071] In order to investigate the effect of drying method and dorsal weighing material on the degradable biowound dressing of the present invention, four kinds of degradable biowound dressings were simultaneously prepared in this embodiment.
[0072] The preparation method of degradable biowound dressing is:
[0073] (1) Adjust the pH value of deionized water to 12, add 1,4-butanediol diglycidyl ether, and mix well to obtain a mixed solution. 2% of the total mass of cellulose derivatives, sodium hyaluronate and cellulose derivatives are fully dissolved in deionized water, the concentration is 2%;
[0074] (2) Dissolve sodium hyaluronate (500kD) and sodium carboxymethylcellulose in the mixed solution, mix well and fully dissolve the biopolysaccharide, react at 30°C for alkaline cross-linking, and cross-link for 6 hours;
[0075] (3) After basic cross-linking, adjust the pH value of the reaction system to 3, carry out acidic cross-linking at 30°C, and cross-link for 10 hours; ...
Embodiment 3
[0091] In this example, 1500kD sodium hyaluronate, water-soluble chitosan, and sodium carboxymethylcellulose were used to prepare a biodegradable biowound dressing, and the dosage relationship of each component is shown in Table 3.
[0092] Table 3 composition ratio
[0093]
[0094] The preparation method is as follows:
[0095] (1) Adjust the pH value of deionized water to 11, add 1,4-butanediol diglycidyl ether, and mix well to obtain a mixed solution. Sodium hyaluronate and cellulose derivatives are fully dissolved in deionized water at a concentration of 5 %;
[0096] (2) Sodium hyaluronate and sodium carboxymethylcellulose were dissolved in the mixed solution, mixed evenly and the biopolysaccharide was fully dissolved, reacted at 35°C for alkaline cross-linking, and cross-linked for 2 hours;
[0097] (3) After alkaline crosslinking, adjust the pH value of the reaction system to 3, and carry out acidic crosslinking at 35°C for 8 hours;
[0098] (4) After alkali-acid...
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