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A kind of simethicone solid self-emulsifying preparation and preparation technology thereof

A simethicone and self-emulsifying technology, applied in the directions of silicon compound active ingredients, digestive system, emulsion delivery, etc., can solve the problems of complex production process of simethicone soft capsules, unfavorable for patients to take, difficult emulsification process, etc., and achieve good application prospects , low cost and convenient transportation

Active Publication Date: 2019-03-29
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(3) Indigestion
After our research on domestic and foreign markets, we found that simethicone suspensions and emulsions have disadvantages such as carrying, inconvenient transportation, and poor stability. Simethicone tablets are not conducive to taking by patients with dysphagia, and simethicone soft capsules have complex production processes. higher cost
Due to the strong hydrophobicity of simethicone, the emulsification process is relatively difficult. At present, there are no relevant research reports on simethicone solid self-emulsifying preparations at home and abroad, and no related products have been listed.

Method used

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  • A kind of simethicone solid self-emulsifying preparation and preparation technology thereof
  • A kind of simethicone solid self-emulsifying preparation and preparation technology thereof
  • A kind of simethicone solid self-emulsifying preparation and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1: the preparation of Simethicone solid self-emulsifying preparation

[0048] The raw and auxiliary materials are composed of:

[0049]

[0050] Preparation:

[0051] (1) Measure simethicone, polyoxyethylene 8 stearate, 1,2-propanediol, mannitol, and 30% ethanol solution according to the above prescription. Add simethicone, polyoxyethylene 8 stearate and 1,2-propylene glycol into the reaction tank, keep warm at 70°C, stir for 30 minutes, and mix well to obtain simethicone self-emulsifying concentrate;

[0052] (2) Pulverize the above-mentioned mannitol, pass through a 100-mesh sieve, then mix evenly with the self-emulsifying concentrated solution obtained in step (1), spray an appropriate amount of 30% ethanol solution, and make a soft material, so as to achieve "lightly holding into a ball and lightly pressing". Scattered" state, passed through a 20-mesh sieve to granulate;

[0053] (3) Dry the granules obtained in the step (2) at 50° C. until the wate...

Embodiment 2

[0054] Embodiment 2: the preparation of Simethicone solid self-emulsifying preparation

[0055] The raw and auxiliary materials are composed of:

[0056]

[0057] Preparation:

[0058] (1) Measure simethicone, polyoxyethylene 40 stearate, glyceryl monostearate, glycerin, PEG4000, 40% ethanol solution according to the above prescription. Add simethicone, polyoxyethylene 40 stearate, glycerol monostearate, and glycerin into a reaction tank, keep the temperature at 75°C, stir for 30 minutes, and mix well to obtain a simethicone self-emulsifying concentrate;

[0059] (2) Grind the above-mentioned PEG4000, pass through a 100-mesh sieve, then mix evenly with the self-emulsifying concentrated solution obtained in step (1), spray an appropriate amount of 40% ethanol solution, and make a soft material, so as to achieve "lightly hold into a ball and lightly press to disperse" ” state, pass through a 20-mesh sieve and granulate;

[0060] (3) Dry the granules obtained in step (2) at...

Embodiment 3

[0061] Embodiment 3: the preparation of Simethicone solid self-emulsifying preparation

[0062] The raw and auxiliary materials are composed of:

[0063]

[0064] Preparation:

[0065] (1) Measure simethicone, polyoxyethylene hydrogenated castor oil, glyceryl monostearate, macrogol 400, lactose, and purified water according to the above prescription. Add simethicone, polyoxyethylene hydrogenated castor oil, glyceryl monostearate, and polyethylene glycol 400 into the reaction tank, keep the temperature at 65°C, stir for 30 minutes, and mix well to obtain the simethicone self-emulsifying concentrate;

[0066] (2) Grind the above-mentioned lactose, pass through a 100-mesh sieve, then mix evenly with the self-emulsifying concentrate obtained in step (1), spray an appropriate amount of purified water, and make a soft material to achieve the effect of "lightly holding into a ball and lightly pressing to disperse" state, granulated through a 20-mesh sieve;

[0067] (3) Dry the ...

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Abstract

The invention discloses a simethicone solid self-emulsifying preparation. The preparation is prepared from, by weight, 2.0-6.0% of simethicone, 2.0-30.0% of emulsifier, 1.0-20.0% of auxiliary emulsifier, 50.0-90.0% of pharmaceutically-acceptable solid adsorption material and 0-10.0% of wetting agent. The invention further provides a preparation method of the simethicone solid self-emulsifying preparation. The method is easy and convenient to operate, low in cost and suitable for industrial production; the obtained product has the advantages of being good in taste, uniform in distribution, high in solubility, stable in quality and the like; the preparation is rapid in dissolution, easy to take, rapid in effect and suitable for the aged, children and people who have difficulty in swallowing, the compliance of patients is increased, and the preparation has more advantages on the aspects of packaging, carrying, transporting and the like compared with a traditional liquid simethicone suspension and emulsifier and has good application prospects on the aspects of treating symptoms such as abdominal distension, abdominal discomfort, dyspepsia and postoperative abdominal distension caused when gas gathers in the abdomen.

Description

technical field [0001] The invention relates to a solid self-emulsifying preparation of simethicone and a preparation process thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Flatulence is a common clinical manifestation of gastrointestinal disturbances. According to research, many gastrointestinal diseases, as well as diseases such as liver, gallbladder, pancreas, and peritoneum, can produce gastrointestinal flatulence; Gas food, such as potatoes, sweet potatoes, taro, pumpkin, chestnut, etc.; these foods are rich in starch, sugar, cellulose, plus the meat eaten, after being fully fermented by intestinal bacteria, a large amount of hydrogen sulfide, If the ammonia gas cannot be discharged for a while, it will accumulate in the intestinal tract, which will cause flatulence in the gastrointestinal tract. The second is that there are several active factors in soy products (including tofu, soy milk, tofu brain, etc.), two...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/695A61K47/14A61K47/44A61K47/26A61P1/14
CPCA61K9/107A61K31/695A61K47/14A61K47/26A61K47/44
Inventor 翟光喜孙丽敏汪洋
Owner SHANDONG UNIV
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