Pharmaceutical composition of aceclofenac and pharmaceutical application thereof

A technology of aceclofenac and its composition, which is applied in the field of aceclofenac pharmaceutical composition, can solve problems such as chronic nephritis-related reports that have not yet been seen, and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2016-08-24
SUZHOU BINUOJIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, there has been no report on the correlation between the pharmaceutical composition of aceclofenac and chronic nephritis

Method used

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  • Pharmaceutical composition of aceclofenac and pharmaceutical application thereof
  • Pharmaceutical composition of aceclofenac and pharmaceutical application thereof
  • Pharmaceutical composition of aceclofenac and pharmaceutical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0023] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0024] Separation method: (a) Grind the dried root of rhubarb (2kg), extract with 75% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate until no alcohol smell (4L), and successively wash with petroleum ether (4L× 3 times), ethyl acetate (4L×3 times) and water-saturated n-butanol (4L×3 times) to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) The ethyl acetate extract in (a) was removed with D101 macroporous resin, first eluted with 8% ethanol for 6 column volumes, then with 70% ethanol for 8 column volumes, collected 70% eluate, and reduced...

Embodiment 2

[0027] Embodiment 2: to the therapeutic effect of rat chronic nephritis model

[0028] The experiment adopts the improved cationized bovine serum albumin (induced chronic glomerulonephritis model, which is one of the preferred animal models for researching therapeutic drugs at present. The positive control drug is tripterygium glycosides tablets Detect changes in biochemical indicators such as urine protein, serum creatinine, and urea nitrogen in experimental rats, make stained pathological sections of kidney tissue, and observe the pathological changes under a light microscope.

[0029] 1. Experimental materials

[0030] (1) Experimental animals

[0031] 90 SD rats (healthy and clean grade), half male and half male, weight standard: 200±15g. Purchased from the Experimental Animal Center of Heilongjiang University of Traditional Chinese Medicine, experimental animal qualification certificate number: SCXK black 2014-004. The laboratory is equipped with exhaust and ventilatio...

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Abstract

The invention discloses a pharmaceutical composition of aceclofenac and a pharmaceutical application thereof. The pharmaceutical composition of aceclofenac, disclosed by the invention, contains aceclofenac and a natural product compound (I) with a novel structure and separated from the dried root of rheum officinale. When the aceclofenac and the natural product compound (I) act separately, the treatment effect on chronic nephritis is relatively low; by combining the aceclofenac and the natural product compound (I), the treatment effect on chronic nephritis is remarkably improved; and the pharmaceutical composition can be developed into a medicine for treating chronic nephritis and has outstanding substantial characteristics and remarkable progress in comparison with the prior art.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of aceclofenac, in particular to a pharmaceutical composition of aceclofenac and its medical application. Background technique [0002] Aceclofenac is a new type of powerful antipyretic, analgesic and anti-arthritic drug, which is clinically suitable for the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, spondylitis, etc. Pain and fever caused by this disease. [0003] This product is a newly synthesized orally effective non-steroidal, phenylacetic acid anti-inflammatory, antipyretic and analgesic drug. Structurally related to diclofenac, aclofenac and fenclofenac. In clinical practice, compared with other non-steroidal drugs (NSAIDs) in its pharmacological effects, it has obvious and extensive anti-inflammatory effects, strong analgesic and antipyretic effects, and gastric toxicity in experimental models of acute and chronic inflammation. as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J73/00A61K31/216A61K31/585A61P13/12
CPCC07J73/003A61K31/216A61K31/585A61K36/708
Inventor 徐珍
Owner SUZHOU BINUOJIA PHARMA CO LTD
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