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Preparation method of minor radix bupleuri granules

The technology of Xiao Chai Hu granules and Xiao Chai Hu is applied in the field of preparation of Xiao Chai Hu granules, which can solve the problems of insufficient extraction of active components, low extraction efficiency of preparation process, unstable performance and the like, and achieves high yield and high content of active components. , the effect of stable performance

Inactive Publication Date: 2016-08-31
HAINAN ZHONGBAO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current prior art Xiaobupleurum granules have a high water content, are prone to moisture absorption and agglomeration, have unstable performance, and have a short shelf life; and the extraction efficiency of the preparation process is low, the active ingredient extraction is insufficient, and the yield is low.

Method used

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  • Preparation method of minor radix bupleuri granules
  • Preparation method of minor radix bupleuri granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A preparation method of Xiaobupleurum granules, comprising the following steps:

[0020] (1) Dynamic extraction:

[0021] First add hot water at 80°C to the extraction tank, then add 240 parts by weight of chopped Bupleurum, 90 parts by weight of Scutellaria baicalensis, 90 parts by weight of Codonopsis pilosula, 90 parts by weight of licorice and 90 parts by weight of Chinese jujube. 3 times of the weight of the medicinal material, continue to add hot water at 80°C to 10 times the weight of the medicinal material, heat the water temperature to 98°C, use a multifunctional dynamic extraction stirring tank for dynamic extraction, and keep the extraction temperature at 98°C. After the extraction is completed, the first For an extract, 90 parts by weight of Pinellia ginger and 90 parts by weight of ginger are percolated with an aqueous ethanol solution to obtain a second extract.

[0022] (2) Centrifugal separation:

[0023] (a) Using a centrifuge to separate the first ex...

Embodiment 2

[0036] A preparation method of Xiaobupleurum granules, comprising the following steps:

[0037] (1) Dynamic extraction:

[0038] First add hot water at 75°C to the extraction tank, then add 230 parts by weight of chopped Bupleurum, 80 parts by weight of Scutellaria baicalensis, 80 parts by weight of Codonopsis pilosula, 80 parts by weight of licorice and 80 parts by weight of Chinese jujube. Continue to add 75°C hot water to 9 times the weight of the medicinal material, heat the water temperature to 92°C, use a multifunctional dynamic extraction stirring tank for dynamic extraction, keep the extraction temperature at 92°C, and obtain the first For an extract, 80 parts by weight of Pinellia ginger and 80 parts by weight of ginger are percolated with an aqueous ethanol solution to obtain a second extract.

[0039] (2) Centrifugal separation:

[0040] (a) Using a centrifuge to separate the first extract obtained in step (1) from solid to liquid, the temperature of the extract i...

Embodiment 3

[0053] A preparation method of Xiaobupleurum granules, comprising the following steps:

[0054] (1) Dynamic extraction:

[0055] First add hot water at 85°C to the extraction tank, then add 250 parts by weight of chopped Bupleurum, 100 parts by weight of Scutellaria baicalensis, 100 parts by weight of Codonopsis pilosula, 100 parts by weight of licorice and 100 parts by weight of Chinese jujube. 4 times of the weight of the medicinal material, continue to add hot water at 85°C to 11 times the weight of the medicinal materials, heat the water to 95°C, use a multifunctional dynamic extraction stirring tank for dynamic extraction, and keep the extraction temperature at 95°C. After the extraction is completed, the first For an extract, 100 parts by weight of Pinellia ginger and 100 parts by weight of ginger are percolated with an aqueous ethanol solution to obtain a second extract.

[0056] (2) Centrifugal separation:

[0057] (a) Using a centrifuge to separate the first extract...

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Abstract

The invention provides a preparation method of minor radix bupleuri granules. The preparation method comprises the following steps: firstly, dynamic extraction: taking radix bupleuri, radix scutellariae, radix codonopsis, radix glycyrrhiza and fructus jujubae, adding a proper amount of water, and dynamically extracting at the temperature of 95+ / -3DEG C to obtain a first extracting solution, and percolating ginger processed pinellia and fresh ginger by using an ethanol-water solution to obtain a second extracting solution; secondly, centrifugal separation: centrifugally separating the first extracting solution to obtain a clarified liquid; thirdly, vacuum concentration: performing vacuum concentration on the clarified liquid and the second extracting solution to obtain minor radix bupleuri extract; fourthly, primary sieving: heating the minor radix bupleuri extract to be boiled and then sieving and filtering; fifthly, spray drying: preparing minor radix bupleuri extract powder; sixthly, granulation: dosing the minor radix bupleuri extract powder and an assistant, uniformly mixing, and granulating; seventhly, secondary sieving: collecting qualified granules. According to the preparation method provided by the invention, the minor radix bupleuri granules with high content of effective components, low possibility of absorbing moisture, stable performance and high finished product rate can be obtained.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparation, and in particular relates to a preparation method of Xiaobupleurum granules. Background technique [0002] Bupleurum, its ingredients mainly contain saikosaponins (saikosapoins a, b, c, d four), sterols, volatile oils (bupleurum alcohol, eugenol, etc.), fatty acids (oleic acid, linoleic acid, palmitic acid, stearic acid Acids, etc.) and polysaccharides, etc., also contain flavonoids, polyols, coumarins and trace elements. The pharmacological effects of Bupleurum mainly include: (1) antipyretic, active ingredients: volatile oil (eugenol, caproic acid, r-undecanoic acid lactone and p-methoxybenzodione), saikosaponin (sapogenin A) . Function: It has obvious antipyretic effect on fever caused by typhoid, paratyphoid vaccine, Escherichia coli liquid, fermented milk, yeast, etc.; and can lower the normal body temperature of animals. (2) Anti-inflammatory, active ingredient: sa...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/16A61K47/40
CPCA61K36/233A61K9/1652A61K36/344A61K36/484A61K36/539A61K36/725A61K36/8888A61K36/9068A61K2236/331A61K2236/333A61K2236/51A61K2236/53A61K2300/00
Inventor 高凯戴初雄庄太波
Owner HAINAN ZHONGBAO PHARMA CO LTD