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Drug for treating pancreatitis

A pancreatitis and drug technology, applied in the field of pancreatic inflammation treatment drugs, can solve problems such as hindering the influence of THC on the nervous system, unsatisfactory treatment effect, etc., and achieve the effect of obvious treatment of pancreatitis, excellent effect, and water content reduction.

Inactive Publication Date: 2016-09-21
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CBD is a non-addictive component in marijuana, which can hinder the influence of THC on the human nervous system, and has pharmacological activities such as anti-spasmodic, anti-rheumatic arthritis, and anti-anxiety. It has also been reported in the treatment of pancreatitis, but it is used alone The therapeutic effect of cannabidiol (CBD) is not ideal

Method used

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  • Drug for treating pancreatitis
  • Drug for treating pancreatitis
  • Drug for treating pancreatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The flowers, leaves, hemp bran and hemp seeds of "Yunma No. 1", an industrial hemp variety grown in Yunnan, are used as raw materials. Take mature industrial hemp hemp seeds, dry, remove impurities, and crush them for later use; use ethanol to extract the crushed hemp seeds (at 60-85°C, heat and extract twice, each time for 1-3 hours ), the ethanol concentration is 95% to 100% (V / V), and the ratio of solid to liquid is 1:5 to 1:20; the extract is filtered out and concentrated under reduced pressure to obtain the industrial hemp hemp seed extract.

[0031] Take the mixture of industrial hemp flowers, leaves and hemp bran in a mass ratio of 1:3:2, dry, remove impurities, and pulverize to 10-60 mesh; supercritical carbon dioxide extraction: put the above-mentioned pulverized industrial hemp raw materials into supercritical In the carbon dioxide extraction device, the extraction temperature is controlled at 40-50°C, the extraction time is 30-90min, the extraction pressure i...

Embodiment 2

[0034] Repeat Example 1, with the following differences: when extracting industrial hemp hemp seeds with ethanol, extract at room temperature, and extract 2 times for each batch of materials, each for 7 to 10 days. A 1:1:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as a raw material for extracting hemp cannabinoids.

[0035] Get 0.3 part of industrial hemp hemp seed extract, 99.7 parts of industrial hemp cannabinoid, mix well, obtain medicine A of the present invention.

Embodiment 3

[0037] Repeat Example 1, the following difference is arranged: when extracting industrial hemp hemp seed with ethanol, adopt ultrasonic assisted extraction, ultrasonic frequency 30~60kHz, power 100~1000W, extraction time 30~60min, leaching temperature 25~ 50°C. A 3:2:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as the raw material for extracting hemp cannabinoids.

[0038] Get 99.7 parts of industrial hemp hemp seed extract, 0.3 part of industrial hemp cannabinoid, mix well, obtain medicine C of the present invention.

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Abstract

The invention discloses a drug for treating pancreatitis. The drug is prepared by evenly mixing 0.3-99.7 parts by weight of industrial hemp seed extract and 99.7-0.3 parts by weight of industrial cannabinoid. It is found through clinical observation that the drug can decrease the activity of serum amylase and lipase and decrease the pancreas coefficient and the water content of pancreatic tissue. The drug can resist acute pancreatitis by inhibiting release of inflammatory factors, reduce concentrations of tumor necrosis factor-alpha and interleukin-1beta in serum or tissue and enhance the activity of glutathion peroxidase in the serum or the pancreatic tissue, and the effect is superior to that of cannabidiol. The drug can be prepared into various different clinically-used dosage forms through a conventional preparation method and is convenient to use.

Description

technical field [0001] The invention belongs to the field of drugs for treating pancreatitis, and in particular relates to a pharmaceutical composition for treating pancreatitis prepared from industrial hemp as a main raw material. Background technique [0002] The cultivation of hemp has a long history. In ancient times, hemp was mainly used to make and process ropes, fishing nets, clothing and paper-making raw materials, as well as oil and food. With the development and progress of society, people found that a toxic ingredient (tetrahydrocannabinol) in marijuana can make people addicted to hallucinations. Many countries in Europe and the United States have banned the cultivation of marijuana for a long time. Due to the high economic value of cannabis, by the 1980s, some European countries had researched and bred low-toxic cannabis varieties and promoted their cultivation. In 1990, the European Community took the lead in urgently revising the agricultural policy, abolished...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61P1/18A61K31/557
CPCA61K36/60A61K31/557A61K2236/333A61K2236/37A61K2300/00
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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