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Traditional Chinese medicine self-microemulsion instant release pill for treating angina pectoris and preparation method thereof

A technology of self-microemulsion and angina pectoris, applied in the field of medicine, can solve the problems of inconspicuous drug effect, insufficient drug loading, inconvenient drug carrying, etc.

Inactive Publication Date: 2016-09-21
赵晶晶
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies in the prior art, and provide a Chinese medicine self-microemulsion quick-release dripping pill for the treatment of angina pectoris and a preparation method thereof, so as to solve the problems in the prior art that the medicine is inconvenient to carry, the drug loading is insufficient, and the drug effect is not good. raised due to obvious technical problems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The invention discloses a traditional Chinese medicine self-microemulsion quick-release dripping pill for treating angina pectoris and a preparation method thereof. The preparation method is as follows:

[0019] 1) Weigh 80g of Patrinia officinalis, 70g of saponin, 80g of yamba, 70g of bean root, 50g of sapphire, 40g of Ma Bao, 60g of Selaginella, 50g of Schisandra, mix and grind, add 1500g to a concentration of 65% ethanol solution, soaked at room temperature for 3 days, filtered to remove residue to obtain extract Ⅰ;

[0020] 2) Add 500 g of water to the filter cake obtained in step 1), heat and boil at 100°C for 2 hours, after cooling, filter, and collect the filtrate to obtain extract II;

[0021] 3) Combine the extract I and the extract II, and obtain the traditional Chinese medicine extract A after decompression, rotary heating and evaporation;

[0022] 4) Add the Chinese medicine extract A to 50ml of diethylene glycol monoethyl ether, carry out ultrasonic disper...

Embodiment 2

[0027] 1) Weigh 120g of Patrinia officinalis, 100g of saponin, 80g of yamba, 70g of bean root, 30g of sapphire, 30g of mabao, 40g of selaginella, 30g of schisandra, after mixing and crushing, add 2500g to a concentration of 80% Soak in ethanol at room temperature for 5 days, filter to remove slag to obtain extract Ⅰ;

[0028] 2) Add 2 times the weight of water to the filter cake obtained in step 1), heat and boil at 100°C for 3 hours, after cooling, filter, and collect the filtrate to obtain extract II;

[0029] 3) Combine the extract I and the extract II, and obtain the traditional Chinese medicine extract A after decompression, rotary heating and evaporation;

[0030] 4) Add the Chinese medicine extract A to 200ml of diethylene glycol monoethyl ether, carry out ultrasonic dispersion and dissolution, and obtain the solution B;

[0031] 5) After mixing 25g of glyceryl monolinoleate, 20g of polyoxyethylene castor oil EL and the solution B, carry out ultrasonic dispersion and d...

Embodiment 3

[0036] Same as each step in embodiment 2, the sampling ratio is the same, the difference is that the speed of dripping in step 7) in embodiment 3 is 60 drops / min; step 5) in each component consumption is: diethylene glycol 200ml of monoethyl ether, 20g of glyceryl monolinoleate, 20g of polyoxyethylene castor oil EL; the organic solvent in step 1) is a 75% ethanol solution, soaked for 3 days at room temperature.

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Abstract

The invention discloses a traditional Chinese medicine (TCM) self-microemulsion instant release pill for treating angina pectoris and a preparation method thereof. The preparation method comprises the following steps: extracting effective medicine ingredients from patrinia, ferrous sulfate, flos rhododendri mollis, euchresta japonica, lapis chloriti, xanthate, selaginella and schisandra chinensis, using the effective medicine ingredients to obtain TCM extracts, mixing and stirring the TCM extracts uniformly with diethylene glycol monoethyl ether, glycerol monolinoleate and cremophor EL before mixing with a preparation liquid to obtain a self-microemulsion solution, and homogenizing the self-microemulsion solution to obtain the instant release pill. The TCM self-microemulsion instant release pill has the remarkable advantages of being convenient to carry, easy to store, convenient to use, high in medicine carrying capacity, quick in drug release and high in bioavailability.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to a traditional Chinese medicine self-microemulsion quick-release dripping pill for treating angina pectoris and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Angina pectoris refers to a group of syndromes with precordial pain as the main clinical manifestation caused by coronary artery insufficiency caused by coronary atherosclerotic stenosis, temporary myocardial ischemia and hypoxia. It is characterized by paroxysmal chest squeezing pain, which may be accompanied by other symptoms. The pain is mainly located at the back of the sternum and can radiate to the precordium and left upper limb. Anemia, tachycardia, etc. often occur during physical exertion, emotional agitation (anger, anxiety, overexcitement), cold, fullness, smoking, etc., which last for several minutes and disappear after rest or nitrate prepar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/57A61K9/20A61K47/44A61K47/34A61K47/08A61K47/14A61P9/10A61K33/26A61K35/38
CPCA61K36/185A61K9/0002A61K9/006A61K9/2013A61K9/2031A61K33/26A61K35/38A61K36/11A61K36/45A61K36/489A61K36/57A61K36/79A61K2236/331A61K2236/333A61K2300/00
Inventor 赵晶晶方瑞陈小葵阳巧凤张琳
Owner 赵晶晶
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