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Preparation method of biodegradable medical polyurethane and chitosan composite hemostatic sponge

A chitosan and polyurethane technology, applied in application, medical science, drug delivery, etc., can solve the problems of poor degradability, unusable medical field, low biodescriptivity, etc., achieve excellent hemostatic performance, improve hemostatic performance, good mechanical properties

Inactive Publication Date: 2016-09-21
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this composite foam has poor degradability and low biodegradability, so it cannot be used in the medical field

Method used

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  • Preparation method of biodegradable medical polyurethane and chitosan composite hemostatic sponge
  • Preparation method of biodegradable medical polyurethane and chitosan composite hemostatic sponge
  • Preparation method of biodegradable medical polyurethane and chitosan composite hemostatic sponge

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] (1) Synthesis of double-terminated hydroxyl prepolymer

[0059] Put 12g of polyethylene glycol 600 (PEG600, 0.02mol) in a vacuum reaction flask, stir with a magnet, remove water under vacuum (20Pa) at 100°C for 3h, cool to room temperature, and equilibrate with argon. Add 15g D,L-lactide, 15gε-caprolactone and 0.126 stannous octoate (0.3% of raw material mass). Evacuate, balance with argon, repeat three times. Vacuumize to 20Pa, seal the vacuum reaction bottle, heat the oil bath to 120°C, and react for 72h to form a multi-terminated hydroxyl prepolymer.

[0060] (2) Synthesis of double-terminated isocyanate-based prepolymers

[0061] With the double-terminated hydroxyl prepolymer prepared in step 1, connect mechanical stirring, argon protection, heat up to 80 ° C, add chain extender HDI-BDO-HDI dimethyl sulfoxide solution (mass concentration 25%, chain extender According to 1.2 times the molar amount of -NCO / -OH added). Continue the constant temperature reaction at ...

Embodiment 2

[0067] (1) Synthesis of double-terminated hydroxyl prepolymer

[0068] Put 12g of PEG600 (0.02mol) in a vacuum reaction bottle, stir with a magnet, remove water under vacuum (20Pa) at 100°C for 3h, cool to room temperature, and equilibrate with argon. Add 10g D,L-lactide, 10gε-caprolactone and 0.126g stannous octoate (0.3% of raw material mass). Evacuate, balance with argon, repeat three times. Vacuumize to 20Pa, seal the vacuum reaction bottle, heat the oil bath to 130°C, and react for 48 hours to form a multi-terminated hydroxyl prepolymer.

[0069] (2) Synthesis of double-terminated isocyanate-based prepolymers

[0070] With the double-terminated hydroxyl prepolymer prepared in step 1, connect mechanical stirring, argon protection, heat up to 75 ° C, add chain extender HDI-BDO-HDI dimethyl sulfoxide solution (mass concentration 25%, chain extender According to 1.25 times the molar amount of -NCO / -OH added). Continue the constant temperature reaction at this temperature ...

Embodiment 3

[0076] (1) Synthesis of double-terminated hydroxyl prepolymer

[0077] Put 12g of PEG800 (0.015mol) in a vacuum reaction bottle, stir with a magnet, remove water under vacuum (20Pa) at 100°C for 3h, cool to room temperature, and equilibrate with argon. Add 18g of L-lactide and 0.045g of dibutyltin diacetate (0.15% of raw material mass). Evacuate, balance with argon, repeat three times. Vacuumize to 20Pa, seal the vacuum reaction bottle, heat the oil bath to 140°C, and react for 24 hours to form a multi-terminated hydroxyl prepolymer.

[0078] (2) Synthesis of double-terminated isocyanate-based prepolymers

[0079] With the double-terminated hydroxyl prepolymer prepared in step 1, connect mechanical stirring, argon protection, heat up to 85 ° C, add chain extender HDI-BDO-HDI dimethyl sulfoxide solution (mass concentration 25%, chain extender According to 1.2 times the molar amount of -NCO / -OH added). Continue the constant temperature reaction at this temperature for 2.5 ho...

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Abstract

The invention discloses a preparation method of biodegradable medical polyurethane and chitosan composite hemostatic sponge. The preparation method comprises the following steps: uniformly mixing chitosan and a double-terminal isocyanato-prepolymer, so that a thick solution is obtained from reaction, and refining and drying so as to obtain a polyurethane and chitosan composite material; and then, dissolving the polyurethane and chitosan composite material in an organic solvent, and freeze-drying so as to obtain the polyurethane and chitosan composite hemostatic sponge. The preparation method of the sponge material, which is a conventional chemical method, is simple and easy to implement. The sponge material integrates the good mechanical property of polyurethane and the excellent hemostatic performance of chitosan. The sponge material is good in biocompatibility and is biodegradable and bio-absorbable, and the degradation time of the sponge material can be controlled by regulating the content of hydrophilic polyether in the prepolymer. The product (the hemostatic sponge) is convenient to use, and is especially suitable for hemostasis of organism narrow cavities (otology, rhinology and dentistry).

Description

technical field [0001] The invention belongs to the technical field of composite adsorption materials, and in particular relates to the preparation of a biodegradable medical polyurethane chitosan composite hemostatic sponge. Background technique [0002] Ear, nose, and dental surgery are common surgical operations. Ear, nose, and dental surgery are small in scope, rich in local blood vessels, easy to bleed, and deep in position, so they cannot be sutured to stop bleeding after surgery, and must rely on packing to stop bleeding. The purpose of packing is to reduce the pain of patients as much as possible while ensuring hemostasis and anti-adhesion. Therefore, the selection of postoperative packing materials has always been the focus of medical attention. [0003] In the case of hemostasis in cavities such as ear, nose, and tooth extraction, traditional non-biodegradable packing materials are usually removed 24-48 hours or even longer after surgery. Commonly used punching pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00C08G18/64C08G18/42C08G18/10
CPCA61L24/08A61L24/0042A61L2400/04C08G18/10C08G18/4081C08G18/42C08G18/6484C08L75/06C08G18/64
Inventor 侯昭升尹胜男李兴侯萍吴茹霞
Owner SHANDONG NORMAL UNIV
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