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Preparation method of medicine for treating cardiovascular disease

A cardiovascular and disease technology, applied in the field of preparation of drugs for the treatment of cardiovascular diseases, can solve problems such as gastrointestinal irritation, side effects, unsuitability for chronic heart disease patients, etc., and achieve the effect of enriching treatment plans

Inactive Publication Date: 2016-10-12
胡小丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also many medicines currently being studied, such as nitroglycerin, which is characterized by quick response and outstanding curative effect on the relief of symptoms of acute patients, but has certain side effects. There are also some Chinese patent medicines, which also have the characteristics of quick response and good effect, but These drugs are not suitable for patients with chronic heart disease; most of the existing drugs for the prevention and treatment of cardiovascular diseases are taken orally, which are irritating to the stomach

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Add 0.2mmol phosphoric acid to diethyl ether, stir at 60°C for 20 minutes, then add 1mmol 4-hydroxy-3-methoxyphenylacrylic acid, 0.5mmol N,N'-dicyclohexylcarboimide, After stirring and reacting for 12 hours, pour the reaction mixture into ice water, stir, then adjust the pH value to 6.5, extract three times with dichloroethane, combine the extract phases, wash with brine three times, then dry with anhydrous sodium sulfate, and remove the solvent After purification by column chromatography, Compound A was obtained;

[0025] (2) Dissolve 1 mmol of Compound A in xylene, add 0.6 mmol of diethyl phosphite dropwise under an ice-water bath; react at room temperature for 5 hours, then add 0.1 mmol of potassium iodide, and continue the reaction for 1.5 hours; then extract with dichloroethane Three times, the extract phases were combined, washed three times with alkaline water, then dried with anhydrous sodium sulfate, and purified by column chromatography after removing the ...

Embodiment 2

[0029] (1) Add 0.2mmol phosphoric acid to diethyl ether, stir at 50°C for 10 minutes, then add 1mmol 4-hydroxy-3-methoxyphenylacrylic acid, 0.5mmol N,N'-dicyclohexylcarboimide, at 70°C After stirring for 10 minutes, pour the reaction mixture into ice water, stir, then adjust the pH value to 6.5, extract three times with dichloroethane, combine the extract phases, wash with brine three times, then dry with anhydrous sodium sulfate, and remove the solvent After purification by column chromatography, Compound A was obtained;

[0030] (2) Dissolve 1 mmol of Compound A in xylene, add 0.6 mmol of diethyl phosphite dropwise under an ice-water bath; react at room temperature for 3 hours, then add 0.1 mmol of potassium iodide, and continue the reaction for 1 hour; then extract with dichloroethane Three times, the extract phases were combined, washed three times with alkaline water, then dried with anhydrous sodium sulfate, and purified by column chromatography after removing the solven...

Embodiment 3

[0034] (1) Add 0.2mmol of phosphoric acid to ether, stir at 50°C for 10 minutes, then add 1mmol of 4-hydroxy-3-methoxyphenylacrylic acid, 0.5mmol of N,N'-dicyclohexylcarboimide, at 70°C After stirring and reacting for 10 h, pour the reaction mixture into ice water, stir, then adjust the pH value to 6.5, extract three times with dichloroethane, combine the extract phases, wash with brine three times, then dry with anhydrous sodium sulfate, and remove the solvent After purification by column chromatography, Compound A was obtained;

[0035] (2) Dissolve 1 mmol of Compound A in xylene, add 0.6 mmol of diethyl phosphite dropwise under an ice-water bath; react at room temperature for 5 hours, then add 0.1 mmol of potassium iodide, and continue the reaction for 1.5 hours; then extract with dichloroethane Three times, the extract phases were combined, washed three times with alkaline water, then dried with anhydrous sodium sulfate, and purified by column chromatography after removing...

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Abstract

The invention discloses a preparation method of a medicine for treating cardiovascular disease. The method comprises the steps as follows: first of all, adding phosphoric acid to diethyl ether, and then adding 4-hydroxy-3-methoxycinnamic acid and N,N'-dicyclohexyl carbodiimide for a reaction to obtain a compound A; dissolving the compound A in xylene, and dropwise adding diethyl phosphite in ice-water bath; then adding potassium iodide for continuous reaction to obtain a compound B; adding the compound B to methylbenzene, and adding ethanol under stirring; adding triethanolamine; performing a reflux reaction for 5-7.5 hours; performing extraction with dichloroethane for three times, combining extract phases, washing the extract phase with deionized water for three times, performing drying with anhydrous sodium sulfate, removing a solvent, and then performing column chromatography purification to obtain a compound C; adding the compound C to a pharmaceutically acceptable carrier to obtain the medicine for treating the cardiovascular disease. The medicine prepared with the method has good therapeutic effect on the cardiovascular disease.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a preparation method of medicines for treating cardiovascular diseases. Background technique [0002] Cardiovascular disease is a very common disease. The clinical manifestations of its symptoms are such as the symptoms of coronary heart disease (including angina pectoris and myocardial infarction): chest tightness, palpitations, restlessness, palpitation and shortness of breath; arrhythmia; chest pain, retrosternal or precordial Pain in the local area; shortness of breath, syncope, weakness, belching; chest pain, immobility, worse at night; coronary heart disease angina pectoris and coronary insufficiency with dark purple tongue and deep pulse; epigastric pain, nausea, Vomiting; left back pain, left arm pain. Due to the rapid economic development, the patterns and aspects of diseases have also changed, thus, cardiovascular diseases have increased significantly, fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/683C07F9/142A61P9/00
CPCA61K31/683C07F9/142
Inventor 胡小丽
Owner 胡小丽
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