Anti-cytomegalovirus medicine composition and preparation method thereof

A cytomegalovirus and composition technology, which can be used in antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of teratogenicity of mammalian fetuses, low efficiency, and unsuitability for pregnant women, so as to ensure safety. , the effect of inhibiting transmission

Inactive Publication Date: 2016-10-12
桂林淮安天然保健品开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prevention and treatment of HCMV perinatal infection is a hot spot of medical research at home and abroad. Although the western drug ganciclovir is effective in treating cytomegalovirus infection, ganciclovir competitively inhibits HCMV DNA polymerase after HCMV enters the target cells. , and incorporated into the DNA of the virus and host cells, thereby inhibiting DNA synthesis and functioning, so the anti-HCMV efficiency of ganciclovir is low. Not only that, ganciclovir has the risk of causing teratogenicity in mammalian fetuses, Therefore, it should not be used in pregnant women

Method used

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  • Anti-cytomegalovirus medicine composition and preparation method thereof
  • Anti-cytomegalovirus medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Formula: 0.1 part of Cordyceps, 1 part of Ganoderma lucidum, 0.5 part of Black Fungus and 8 parts of Luo Han Guo.

[0030] Preparation:

[0031] 1) Crush the formula amount of Cordyceps, Ganoderma lucidum, and black fungus, and extract with 90v% ethanol as a solvent. The amount of ethanol is 8 times the weight of the mixed powder. The extract is refluxed for 1 hour, the extract is filtered, and the filter residue is taken for later use;

[0032] 2) Add water to extract the filter residue of step 1), the amount of water added is 8 times the weight of the filter residue, reflux extraction for 1 hour, filter the extract, and take the filtrate for use;

[0033] 3) Crushing Luo Han Guo, using 90v% ethanol as a solvent for extraction, the amount of ethanol is 8 times the weight of Luo Han Guo powder, refluxing for 1 hour, filtering the extract, and taking the filter residue for use;

[0034] 4) Add water to extract the filter residue of step 3), the amount of water added is 8 times the...

Embodiment 2

[0039] Formula: 0.5 parts of Cordyceps, 2 parts of Ganoderma lucidum, 1 part of Black Fungus and 10 parts of Luo Han Guo.

[0040] Preparation:

[0041] 1) Crush the formula amount of Cordyceps, Ganoderma lucidum, and black fungus, and extract with 95v% ethanol as a solvent. The amount of ethanol is 10 times the weight of the mixed powder. The extraction is refluxed 3 times, each 3h, the extracts are combined, filtered, Take the filter residue for later use;

[0042] 2) Extract the filter residue of step 1) with water, the amount of water added is 10 times the weight of the filter residue, reflux extraction 3 times, each 3h, combine the extracts, filter, and take the filtrate for use;

[0043] 3) Crushing Luo Han Guo, using 95v% ethanol as a solvent for extraction, the amount of ethanol used is 10 times the weight of Luo Han Guo powder, reflux extraction 3 times, each 3 hours, the extracts are combined, filtered, and the filter residue is taken for later use;

[0044] 4) Extract the fi...

Embodiment 3

[0049] Formula: 0.2 parts of Cordyceps, 1.5 parts of Ganoderma lucidum, 0.6 parts of Black Fungus and 9 parts of Luo Han Guo.

[0050] Preparation:

[0051] 1) Crush the formula amount of Cordyceps, Ganoderma lucidum, and black fungus, and extract with 90v% ethanol as a solvent. The amount of ethanol is 9 times the weight of the mixed powder. The extract is refluxed for 2 times, 2h each time. The extracts are combined and filtered. Take the filter residue for later use;

[0052] 2) Extract the filter residue of step 1) with water, the amount of water added is 9 times the weight of the filter residue, reflux extraction 2 times, 2h each time, combine the extracts, filter, and take the filtrate for use;

[0053] 3) Crushing Luo Han Guo, using 95v% ethanol as a solvent for extraction, the amount of ethanol is 9 times the weight of Luo Han Guo powder, reflux extraction 2 times, 2 hours each time, combine the extracts, filter, and take the filter residue for later use;

[0054] 4) Add water ...

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Abstract

The invention discloses an anti-cytomegalovirus medicine composition and a preparation method thereof. The medicine composition is prepared from the following components in parts by weight: 0.1-0.5 part of cordyceps sinensis, 1-2 parts of lucid ganoderma, 0.5-1 part of black fungus and 8-10 parts of momordica grosvenori. The preparation method comprises the following steps: (1) extracting cordyceps sinensis, lucid ganoderma and black fungus with alcohol, filtering residues, and extracting with water to obtain a filtrate for later use; (2) extracting momordica grosvenori with alcohol, filtering residues, and extracting with water to obtain filtrate for later use; (3) filtering the filtrate in the step (2) with a membrane filter device having a molecular weight cut-off of 1000 daltons, and collecting an effluent; (4) filtering the filtrate in the step (1) with a membrane filter device having a molecular weight cut-off of 15000 daltons, and collecting a concentrated solution; and (5) uniformly mixing the effluent and the concentrated solution, concentrating and drying. The medicine composition can be used for preventing HCMV from entering receptor cells and repressing replication of HCMV, so that safety of mother and infants can be comprehensively guaranteed.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to an anti-cytomegalovirus medicine composition and a preparation method thereof. Background technique [0002] Human cytomegalovirus (HCMV) infection is very common in the population, most of which are clinically invisible or latent infection. The virus is an important pathogen causing congenital and perinatal infections. Active HCMV infection during pregnancy can be transmitted vertically through the placenta, causing miscarriage, deformity, stillbirth, and neonatal nervous system and organ damage. However, the natural negative rate of pregnant women infected with cytomegalovirus is about 40%. In order to prevent the fetus from being infected with cytomegalovirus in the uterus and through the birth canal, reduce the chance of infection, and prevent birth defects such as premature delivery, miscarriage, and fetal malformations, medications are needed. The reproduction of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/42A61P31/22
CPCA61K36/068A61K36/07A61K36/074A61K36/42A61K2236/331A61K2236/333A61K2236/53A61K2300/00
Inventor 苏华
Owner 桂林淮安天然保健品开发有限公司
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