Traditional Chinese medicine composition for treating early woman amenorrhea and preparing method thereof
A composition and amenorrhea technology, applied in the directions of drug combination, pharmaceutical formula, drug delivery, etc., can solve the problems of abnormal pituitary gland or hypothalamus function, damage to the health of patients, incomplete genitalia, etc., to increase the cost and reduce the curative effect. , good safety effect
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[0091] The preparation steps of the oral capsule of the present invention are as follows: get 1000g Magnolia officinalis, 1000g Caulis Spatholobus, 1000g Cornus officinalis, 1000g Motherwort, 1000g Atractylodes ulmoides, 1000g Eucommia ulmoides, 1000g Shouwu, Ligustrum lucidum 1000g, Eclipta 1000g, Achyranthes bidentata 1000g, Raspberry 1000g, Cuscuta 1000g, Epimedium 1000g, Danpi 1000g, Pueraria 1000g, Polygala 1000g, Qingpi 1000g, Corydalis 1000g, Angelica 10-20 parts, soak in water for 30 minutes to 1 hour, heat and boil for 30-40 minutes, filter , and the filtrate is set aside; add water to the filter residue, heat for the second time, boil for 30-40 minutes, filter, and set aside the filtrate; add water to the filter residue, heat and boil for the third time for 30-40 minutes, and filter; combine the three filtrates together, heat and concentrate to a paste After drying in an oven, it becomes a fine powder, which is blended with dextrin to make granules, and packed into ca...
Embodiment 3
[0108] 2.1. Tested substance: name: suppository of the present invention (prepared by the method of Example 3)
[0109] 2.2. Experimental animals: Grade 1 white rabbits with large ears, 10 females, weighing 2.1-2.3kg; provided by the Experimental Animal Center of the Department of Biology, Qingdao University School of Medicine;
[0110] 2.3. Test method:
[0111] 10 healthy rabbits with intact skin were selected, and the hair on both sides of the back and spine was cut off 24 hours before the test. The left and right areas of hair removal were about 4cm×4cm. During the test, take 0.2ml of the test substance and apply it on two layers of gauze of 2.5cm×2.5cm, apply it on one side of the depilated skin surface, cover it with oil paper, and fix it with adhesive tape. The skin on the other side was used as a blank control. After 4 hours of sealing, remove the cover, wash with warm water to remove the residual test substance, treat the skin reaction at the application site 1, 24 ...
Embodiment 4
[0120] Embodiment 4: skin allergy test result
[0121] Use the suppository of the present invention to carry out induction and excitation contact tests, and treat the test mice after 24 hours and 48 hours, and there is no phenomenon such as erythema and edema in the skin, and there is no difference with the negative control group. The results show that the suppository has close to zero skin reaction intensity, that is, no skin allergy.
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