Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Bionic gynecological lotion and preparing method thereof

A gynecological lotion and biomimetic technology, which can be used in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of short residence time, poor vaginal compatibility, and reduced biological activity of antimicrobial peptides. and other problems, to achieve the effect of vaginal acidity repair, simple preparation method and balance of vaginal flora

Active Publication Date: 2016-10-12
GUANGDONG COOWAY BIOTECH CO LTD
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After research, the applicant found that the product had the following disadvantages: ①The biological activity of the antimicrobial peptide was reduced due to the high-salt environment of the artificial body fluid, which eventually led to a significant weakening of its antimicrobial ability; ②Is the composition of the artificial body fluid and human vaginal fluid or There is a big difference, and it is not bionic in the true sense, so its compatibility with the vagina is poor; ③ the product is mainly used to kill harmful bacteria in the vagina to achieve the purpose of treating vaginitis, but it does not affect the vaginal flora. There is no balancing effect, and it cannot repair the damage caused by vaginitis to the vagina, so vaginitis is easy to recur, and people with a history of vaginitis are still high-risk groups of vaginitis; ④ It is because the lotion stays in the vagina for a short time The action time of antimicrobial peptides is too short, so in order to achieve the ideal antibacterial effect, the vagina needs to be repeatedly lavaged every time it is used, and the relationship between multiple times is easy to damage the microenvironment inside the vagina

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bionic gynecological lotion and preparing method thereof
  • Bionic gynecological lotion and preparing method thereof
  • Bionic gynecological lotion and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1, a kind of bionic gynecological lotion

[0032] The present embodiment 1 bionic gynecological lotion is composed of the following components: housefly antimicrobial peptide 0.1g, xylooligosaccharide 6.0g, xanthan gum 0.1g, NaCl 8.0g, KCl 0.45g, CaCl 2 0.15g, NaHCO 3 0.4g, MgCl 2 ·6H 2 O 0.015g, MgSO 4 ·7H 2 O 0.05g, KH 2 PO 4 0.06g, Na 2 PHO 4 12H 2 0.06g, glucose 1.0g, urea 1.5g, Gram-positive bacterial cell fragments 0.002g, be settled to 1L with deionized water, wherein, described growth factor is made of recombinant human epidermal growth factor and recombinant human basic fibroblast The cell growth factor is composed at a weight ratio of 1:1, and the Gram-positive bacterial cell fragments are composed of bifidobacterium cell fragments and lactobacillus cell fragments at a weight ratio of 1:1.

[0033] Preparation:

[0034] A) NaCl, KCl, CaCl 2 , NaHCO 3 , MgCl 2 ·6H 2 O, MgSO 4 ·7H 2 O. KH 2 PO 4 、Na 2 PHO 4 12H 2 O, urea, Gram...

Embodiment 2

[0037] Embodiment 2, a kind of bionic gynecological lotion

[0038] The bionic gynecological lotion of Example 2 is composed of the following components: 0.1 g of housefly antimicrobial peptide, 6.0 g of xylooligosaccharide, 0.1 g of xanthan gum, 8.0 g of NaCl, 0.45 g of KCl, and 0.45 g of CaCl 2 0.15g, NaHCO 3 0.4g, MgCl 2 ·6H 2 O 0.015g, MgSO 4 ·7H 2 O 0.05g, KH 2 PO 4 0.06g, Na 2 PHO 4 12H 2 O0.06g, glucose 1.0g, urea 1.5g, Gram-positive bacterial cell fragments 0.002g, water-soluble VE0.4g, natural moisturizing factor 0.2g and free amino acid 0.4g, be fixed to 1L with deionized water, wherein, The growth factor is composed of recombinant human epidermal growth factor and recombinant human basic fibroblast growth factor in a weight ratio of 1:1, and the free amino acid is composed of glycine, alanine, aspartic acid and serine in a 1:1 ratio. : 1:1 weight ratio, the Gram-positive bacterial cell fragments are composed of bifidobacterium cell fragments and lactoba...

Embodiment 3

[0040] Embodiment 3, a kind of bionic gynecological lotion

[0041] The bionic gynecological lotion of Example 3 is composed of the following components: 0.2 g of housefly antimicrobial peptide, 5.0 g of xylooligosaccharide, 0.1 g of xanthan gum, 8.0 g of NaCl, 0.45 g of KCl, and 0.45 g of CaCl 2 0.15g, NaHCO 3 0.4g, MgCl 2 ·6H 2 O 0.015g, MgSO 4 ·7H 2 O 0.05g, KH 2 PO 4 0.06g, Na 2 PHO 4 12H 2 O0.06g, glucose 1.0g, urea 1.5g, Gram-positive bacterial cell fragments 0.001g, water-soluble VE 0.4g, natural moisturizing factor 0.2g and free amino acid 0.4g, use deionized water to make up to 1L, wherein, The growth factor is composed of recombinant human epidermal growth factor and recombinant human basic fibroblast growth factor in a weight ratio of 1:1, and the free amino acid is composed of glycine, alanine, aspartic acid and serine in a 1:1 ratio. : 1:1 weight ratio, the Gram-positive bacterial cell fragments are composed of bifidobacterium cell fragments and lacto...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of personal cleaning articles and particularly relates to a bionic gynecological lotion and a preparing method thereof. The gynecological lotion is prepared from musca domestica antibacterial peptide, xylooligosaccharide, xanthan gum and artificial simulation vagina secretion with the pH ranging from 3.3 to 4.8, wherein the content of musca domestica antibacterial peptide, the content of xylooligosaccharide and the content of xanthan gum in artificial simulation vagina secretion are 0.1-10.0 g / L, 5-10.0 g / L and 0.05-0.15 g / L respectively. The bionic gynecological lotion has the functions of performing sterilization, regulating the vagina flora and repairing the vagina, and has a remarkable treatment effect on various types of vaginitis.

Description

technical field [0001] The invention belongs to the field of personal cleaning products, and in particular relates to a bionic gynecological lotion and a preparation method thereof. Background technique [0002] Vaginitis is the inflammation of vaginal mucosa and submucosal connective tissue, and is the most common disease in gynecology. Due to the anatomical and biochemical characteristics of normal healthy women, the vagina has a natural defense function against the invasion of pathogens. When the natural defense function of the vagina is destroyed, the pathogens will take the opportunity to invade and cause vaginal inflammation. According to statistics, more than 80% of married women of childbearing age in my country are troubled by this disease, whether mild or severe. [0003] Vaginitis is mainly caused by the imbalance of flora in the vagina, that is, the imbalance of the micro-ecological balance (flora) normally parasitic in the vagina, the beneficial bacteria such a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K47/48A61P15/02A61P31/04A61K31/702A61K31/715A61K35/745A61K35/747
CPCA61K9/08A61K31/702A61K35/74A61K38/17A61K47/36A61K38/1767A61K9/0034A61K31/715A61K35/745A61K35/747A61K2300/00
Inventor 陈松彬易萍张爱萍倪彦艳吴纯玲
Owner GUANGDONG COOWAY BIOTECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products