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Medical dressing with capacity of intelligently releasing antibacterial agent and preparation method of medical dressing

A technology of antibacterial agent and ability, which is applied in the field of medical dressing with intelligent release antibacterial agent and its preparation, can solve the problems of low mechanical strength of hydrogel, increased toxicity of gel system, fragility, etc., and achieve good barrier effect, Effects of avoiding further aggravation and reducing the incidence rate

Active Publication Date: 2016-10-12
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrogels currently used are basically made by one of chemical cross-linking, radiation cross-linking and physical cross-linking. The hydrogel synthesized by a single method contains a large amount of water to increase the molecular chain length between cross-linking points. Factors such as too wide distribution lead to low mechanical strength of the hydrogel and are very brittle, and chemical cross-linking inevitably introduces cross-linking agents, initiators, and organic solvents during the synthesis process, which will increase the toxicity of the gel system

Method used

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  • Medical dressing with capacity of intelligently releasing antibacterial agent and preparation method of medical dressing
  • Medical dressing with capacity of intelligently releasing antibacterial agent and preparation method of medical dressing
  • Medical dressing with capacity of intelligently releasing antibacterial agent and preparation method of medical dressing

Examples

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Embodiment 1

[0044] combine figure 1 It can be seen that this embodiment discloses a medical dressing with the ability to intelligently release antibacterial agents. The material of the medical dressing is non-woven fabric 4, and the non-woven fabric is preferably medical non-woven fabric, and in the front direction of the non-woven fabric 4 A waterproof and moisture-permeable layer 3 is sprayed, and the waterproof and moisture-permeable layer 3 is composed of polyurethane nanofiber membrane. In this embodiment, the pore size of the polyurethane nanofiber membrane is controlled between 0.2 and 1 μm. Because the pore size is too large, the waterproof ability of the polyurethane nanofiber membrane and the ability to block particles such as bacteria will decrease, while the pore size is too small, which is not conducive to dressing. To play the role of moisture permeability, the pore size of the polyurethane nanofiber membrane is between 0.2 and 1 μm, which ensures a good barrier effect on ba...

Embodiment 2

[0049] The invention also discloses a preparation method of a medical dressing capable of intelligently releasing antibacterial agents, and the preparation steps are as follows:

[0050] 1) Polyurethane nanofibers are prepared by thermoplastic nanofiber preparation technology, and polyurethane nanofiber suspensions are obtained under high-speed dispersion and shearing, and the average diameter of nanofibers in the polyurethane nanofiber suspensions is controlled between 200 and 700nm. The mass concentration percentage of nanofiber suspension is 20~35% (the nanofiber diameter of the polyurethane nanofiber suspension prepared in this implementation is preferably 300~350nm, and the mass concentration percentage of the polyurethane nanofiber suspension that prepares is 25% ); then the polyurethane nanofiber suspension is evenly sprayed on the front of the medical non-woven fabric, and dried with hot air, and the non-woven fabric is prepared to be compounded with a polyurethane nano...

Embodiment 3

[0054] By adopting the preparation method of Example 2, the hydrogel of the prepared medical dressing with intelligent release antibacterial agent is scanned under a scanning electron microscope, and obtained figure 2 The illustration shown, from figure 2 It can be seen from the figure that the initial surface structure of the hydrogel loaded with antibacterial agent is compact; then, the equal mass of the hydrogel of the medical dressing was soaked in the same volume of bacteria-free solution and bacteria solution for the same time, soaking After 30min, dry, then scan under scanning electron microscope, obtained respectively image 3 and Figure 4 The illustration shown, from image 3 It can be observed that the surface of the hydrogel layer soaked in the bacteria-free solution swells and collapses, but no obvious cracking occurs; from Figure 4 It can be seen in the figure that the hydrogel layer loaded with antibacterial agent was obviously cracked after soaking in the...

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Abstract

The invention discloses a medical dressing with the capacity of intelligently releasing an antibacterial agent and a preparation method of the medical dressing, and belongs to the field of medical dressing materials. The medical dressing is made of a non-woven fabric, and the obverse side of the non-woven fabric is coated with a waterproof and moisture-permeable layer which is made of a polyurethane nanofiber membrane; the surface of the waterproof and moisture-permeable layer is coated with a hydrogel layer which is made of hydrogel, and the antibacterial agent is loaded in the hydrogel; the reverse side of the non-woven fabric is also coated with a waterproof layer. The invention further provides the preparation method. The preparation method comprises the steps that firstly, the non-woven fabric composited with the polyurethane nanofiber membrane is prepared, and the reverse side of the non-woven fabric is coated with a polyvinylidene fluoride solution to obtain a polyvinylidene fluoride waterproof layer; secondly, the hydrogel loaded with the antibacterial agent is applied to the surface of the polyurethane nanofiber membrane, standing is conducted, and then the medical dressing with the capacity of intelligently releasing the antibacterial agent is obtained. The preparation method is simple, and the medical dressing prepared through the method not only is good in waterproof and moisture-permeable effect, but also can intelligently release the antibacterial agent to reduce bacterial drug resistance.

Description

technical field [0001] The invention belongs to the field of medical dressing materials, and in particular relates to a medical dressing capable of intelligently releasing antibacterial agents and a preparation method thereof. Background technique [0002] Nano-hydrogels are hydrogel particles with a particle size of 1-1000nm, which can be stably dispersed in water to form a colloidal system. Smart nanohydrogels are nanohydrogels that can respond to external stimuli, so they are also called stimuli-responsive nanohydrogels. External stimuli usually include slight changes in ambient temperature, pH and ionic strength of the dispersion medium, as well as light, magnetic field, specific chemical substances or biological substances, etc. [0003] Medical dressings are a class of important medical materials used to cover sores, wounds or other injuries. They can replace damaged skin to act as a temporary barrier, avoid or control wound infection, and provide an environment condu...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/24A61L15/44A61F13/00
CPCA61L15/24A61L15/26A61L15/46A61F13/00063A61F13/00991A61L2300/406A61F13/01029A61F13/01017C08L75/04C08L33/02C08L33/14
Inventor 鲁振坦王栋张佳琪王雯雯王小俊王跃丹蒋海青
Owner WUHAN TEXTILE UNIV
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