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Geniposide-rich hydrophilic molecularly imprinted polymer, preparation method and application

A technology of geniposide and molecular imprinting, which is applied in the field of separation to achieve effects of reduced impact, easy operation, and good application prospects

Active Publication Date: 2016-10-26
SHANDONG ANALYSIS & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The extract containing geniposide uses a hydrophilic medium as a solvent, and a hydrophilic molecularly imprinted polymer must be prepared to achieve highly selective adsorption of geniposide in the hydrophilic medium, and then the extract is subjected to geniposide Targeted enrichment, at present, there is no report on the hydrophilic molecularly imprinted polymer and its preparation method for enriching geniposide

Method used

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  • Geniposide-rich hydrophilic molecularly imprinted polymer, preparation method and application
  • Geniposide-rich hydrophilic molecularly imprinted polymer, preparation method and application
  • Geniposide-rich hydrophilic molecularly imprinted polymer, preparation method and application

Examples

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preparation example Construction

[0032] Preparation of hydrophilic geniposide molecularly imprinted polymers:

[0033] (1) material preparation

[0034] Each raw material component is formulated according to the following dosage ratio: template molecule geniposide 0.91g, alkenyl glycoside glucose (R 1 =OH,R 2 =OH) 1.98g, crosslinking agent N,N-methylenebisacrylamide 16.17g, initiator azobisisobutyronitrile 0.08g, pore forming agent deionized water 55.31g;

[0035] (2) Preparation of molecularly imprinted polymers with template molecules

[0036]Add the above prepared geniposide, alkenyl glycoside glucose, N,N-methylenebisacrylamide, azobisisobutyronitrile, and deionized water into the reaction kettle and mix evenly, ultrasonically degas for 15 minutes, and then Fill with nitrogen and deoxygenate for 15 minutes, seal and polymerize in a constant temperature oil bath at 60°C for 24 hours to obtain a polymer with template molecules;

[0037] (3) Preparation of molecularly imprinted polymers that remove templ...

Embodiment 2

[0042] Preparation of hydrophilic geniposide molecularly imprinted polymers:

[0043] Each raw material component is formulated according to the following dosage ratio: template molecule geniposide 0.99g, alkenyl glycoside glucose (R 1 =OH,R 2 =OCOCH 3 ) 2.11g, crosslinking agent N,N-methylenebisacrylamide 17.26g, initiator azobisisobutyronitrile 0.09g, pore forming agent deionized water 55.47g. The preparation process of the molecular imprinted polymer was the same as that in Example 1, and finally 18.3 g of the molecularly imprinted polymer was obtained. Its hydrophilicity was measured by contact angle test, and the contact angle was 47 degrees, indicating that it was hydrophilic.

[0044] Application of hydrophilic geniposide molecularly imprinted polymers in the purification and enrichment of geniposide:

[0045] Take 10 g of the molecularly imprinted polymer prepared in this example and pack it into a column, weigh 10 g of Gardenia jasmine, crush it, add 250 mL of dei...

Embodiment 3

[0047] Preparation of hydrophilic geniposide molecularly imprinted polymers:

[0048] Each raw material component is formulated according to the following dosage ratio: template molecule geniposide 1.03g, alkenyl glycoside glucose (R 1 =OH,R 2 =OCOCH=CH 2 ) 2.22g, crosslinking agent N,N-methylenebisacrylamide 16.26g, initiator azobisisovaleronitrile 0.10g, pore forming agent deionized water 53.33g. The process of preparing molecularly imprinted polymers was the same as that in Example 1, and finally 19.7 g of molecularly imprinted polymers were obtained. The hydrophilicity was measured by the contact angle test, and the contact angle was 41 degrees, indicating that it was hydrophilic.

[0049] Application of hydrophilic geniposide molecularly imprinted polymers in the purification and enrichment of geniposide:

[0050] Take 10 g of the molecularly imprinted polymer prepared in this example and pack it into a column, weigh 10 g of Gardenia jasmine, crush it, add 250 mL of d...

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Abstract

The invention discloses a geniposide-rich hydrophilic molecularly imprinted polymer, a preparation method and application, and belongs to the technical field of separation. Template geniposide, an alkenyl glucoside functional monomer, a cross-linking agent, an initiator and an pore-forming agent are added in an aqueous solvent system, the alkenyl glucoside functional monomer and the template molecule form a non-covalent template-monomer complex through invertible self-assembly, the template geniposide is removed, and the geniposide-rich hydrophilic molecularly imprinted polymer is obtained. The alkenyl glucoside functional monomer is used for the first time to prepare the geniposide molecularly imprinted polymer in the water phase; compared with a traditional molecularly imprinted polymer prepared from a liposoluble functional monomer, the polymer prepared in the water phase has good hydrophilia, and has better adsorption performance in a water medium.

Description

technical field [0001] The invention belongs to the field of separation technology, and specifically relates to a hydrophilic molecularly imprinted polymer enriched in geniposide, a preparation method and application thereof. Background technique [0002] Gardenia is the dry and mature fruit of Gardenia jasminoides Ellis, a Rubiaceae plant. According to Part I of the 2015 edition of "Chinese Pharmacopoeia", it has the effects of purging fire and relieving restlessness, clearing away heat and diuresis, cooling blood and detoxifying, and is mainly used to treat fever and upset, jaundice, red urine, bloody stranguria and pain, red eyes, swelling and pain, fire poisonous sores , sprain and contusion pain, is a commonly used traditional Chinese medicine blindly. Studies in recent years have shown that geniposide is one of the main active ingredients, and there are many extraction methods for it. Generally, an organic solvent is used to extract in a Soxhlet extractor to obtain t...

Claims

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Application Information

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IPC IPC(8): C08F222/38C08F216/14C08J9/26B01J20/26B01J20/30B01D15/20C07H17/04C07H1/08
CPCB01D15/20B01J20/268C07H1/08C07H17/04C08F222/385C08J9/26C08J2201/0422C08J2335/00C08F216/1416
Inventor 纪文华王晓刘峰段文娟崔莉耿岩玲
Owner SHANDONG ANALYSIS & TEST CENT
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