Joint lubricating material and preparation method thereof

A technology for lubricating materials and joints, applied in the field of O-carboxymethyl chitosan hydrogel, which can solve problems such as the impact of histocompatibility in vivo, and achieve the effects of controllable gelation time, high water content, and low cost

Inactive Publication Date: 2016-10-26
SHENZHEN BRIGHT WAY NOVEL BIO MATERIALS TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, CTS is only soluble in dilute acid aqueous solution, and this hydrogel needs to use a large amount of ionic cross-linking agent, which affects its biocompatibility, especially in vivo tissue compatibility.

Method used

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  • Joint lubricating material and preparation method thereof
  • Joint lubricating material and preparation method thereof
  • Joint lubricating material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A1. Preparation of O-CMCH: Weigh 5.0g of chitin, and weigh 5.9g of NaOH to prepare a NaOH solution with a concentration of 20% by mass according to the ratio of chitin repeating unit to NaOH molar ratio of 1:6. Disperse the plain powder in NaOH solution, stir evenly, vacuumize in a vacuum drying oven for 30 minutes, and put it into a -20°C refrigerator overnight after the alkali penetration is complete. Thaw the next day, transfer the alkalized chitin into the reaction kettle, add 50mL of dispersant n-propanol, stir well at room temperature, add 1.86g of chloroacetic acid in four times (completely added within 1h), and react at a constant temperature of 10°C for 6h. After the reaction is finished, filter with suction, dissolve the filter residue in water, add hydrochloric acid to adjust the pH to about 8, and then filter with a 400-mesh filter cloth. The filtrate is ultra-filtered 5 times, and the volume compression ratio is 1 / 5 each time. 10,000, the concentrated solut...

Embodiment 2

[0042] A1. Preparation of O-CMCH: Weigh 5.0g of chitin, and weigh 11.03g of KOH to form a KOH solution with a mass percentage concentration of 25% according to the molar ratio of chitin repeating unit and KOH of 1:8.0. Disperse the plain powder in the KOH solution, stir evenly, vacuumize in a vacuum drying oven for 30 minutes, and freeze in a -20°C refrigerator overnight after the alkali has penetrated completely. After thawing the next day, transfer the alkalized chitin into the reaction kettle, add 75mL of dispersant isopropanol, stir well at room temperature, add 2.33g of chloroacetic acid in four times (completely added within 1h), and react at a constant temperature of 15°C for 5h. After the reaction is finished, filter with suction, dissolve the filter residue in water, add hydrochloric acid to adjust the pH to about 8, and then filter with a 400-mesh filter cloth. The filtrate is ultra-filtered 5 times, and the volume compression ratio is 1 / 5 each time. 10,000, the conc...

Embodiment 3

[0046] A1. Preparation of O-CMCH: Weigh 5.0g of chitin, and weigh 8.87g of NaOH to prepare a NaOH solution with a mass percentage concentration of 35% according to the molar ratio of chitin repeating unit and NaOH of 1:9.0. Disperse the plain powder in NaOH solution, stir evenly, vacuumize in a vacuum drying oven for 30 minutes, and put it into a -20°C refrigerator overnight after the alkali penetration is complete. Thaw the next day, transfer the alkalized chitin into the reaction kettle, add 90mL of dispersant isopropanol, stir well at room temperature, add 3.49g of chloroacetic acid in four times (completely added within 1h), and react at a constant temperature of 20°C for 3.5h . After the reaction is finished, filter with suction, dissolve the filter residue in water, add hydrochloric acid to adjust the pH to about 8, and then filter with a 400-mesh filter cloth. The filtrate is ultra-filtered 5 times, and the volume compression ratio is 1 / 5 each time. 10,000, the concent...

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Abstract

The invention discloses a joint lubricating material and a preparation method thereof. The material is covalent crosslinked O-carboxymethyl chitosan hydrogel, wherein the gelation time is 0.5-10min, the water content is higher than 70%, and the water retention rate is higher than 65%; and the material is prepared by carrying out gelation reaction between O-carboxymethyl chitosan of which the degree of deacetylation is greater than 25% and glutaric dialdehyde. The prepared covalent crosslinked O-carboxymethyl chitosan hydrogel has good biocompatibility, can serve as a joint lubricating agent, is suitable for local injection of joints, and can enable the joints to keep certain capacity and elastic properties within certain time so as to promote cartilage tissue repair.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to an O-carboxymethyl chitosan (O-CMCTS) hydrogel used for joint lubrication. Background technique [0002] With the improvement of living standards, the average life expectancy of human beings is gradually extended, and population aging has become a very important social problem today. It is estimated that by around 2050, the elderly population in the country will reach 1 / 3 of the total population in the country, and bone and joint degenerative diseases It is a common disease among middle-aged and elderly people, and the prevalence rate of the elderly over 65 years old reaches 50%. In addition, long-term excessive exercise of young and middle-aged people leads to wear of articular cartilage is also a common clinical disease, and it has a continuous upward trend, seriously affecting the quality of life. Therefore, it is necessary to develop effective artificial joint l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08C08B37/08A61L31/04A61L31/14
CPCA61L31/042A61L31/14A61L2400/06C08B37/003C08J3/075C08J3/24C08J2305/08C08L5/08A61L31/04
Inventor 吴奕光杨帆江长兵吴灿光薛清辉
Owner SHENZHEN BRIGHT WAY NOVEL BIO MATERIALS TECH CO LTD
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