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Preparation method of nanofibrous membrane with core/shell structure loaded with traditional Chinese medicine asiaticoside and application in wound dressing

A nanofiber membrane and asiaticoside technology, which is applied in fiber processing, medical science, filament/thread forming, etc., can solve the problem of no obvious promotion effect on wound healing, instability of asiaticoside, easy damage to new tissue, etc. problems, achieve excellent biodegradability, easy large-scale industrial production, and promote wound healing

Active Publication Date: 2019-04-12
杭州珈晟生物数字技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional medical dressings are mainly made of gauze, cotton and other materials for cleaning or protecting wounds. They are cheap and easy to make, but they have congenital defects that are difficult to overcome: they have no obvious promotion effect on wound healing; dressing changes can cause pain and are easy to Damage new tissue; when the dressing is soaked, pathogens can easily pass through; the workload of dressing change is heavy, etc.
Considering that asiaticoside is unstable and easily inactivated, it can be used as the main drug, and there are few reports on the preparation of drug-loaded electrospun fiber membranes with a core / shell structure by coaxial electrospinning technology.

Method used

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  • Preparation method of nanofibrous membrane with core/shell structure loaded with traditional Chinese medicine asiaticoside and application in wound dressing
  • Preparation method of nanofibrous membrane with core/shell structure loaded with traditional Chinese medicine asiaticoside and application in wound dressing
  • Preparation method of nanofibrous membrane with core/shell structure loaded with traditional Chinese medicine asiaticoside and application in wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Dissolve lactic acid / glycolic acid copolymer (PLGA) in a mixed solution of dichloromethane and N,N-dimethylformamide (the volume ratio of dichloromethane to N,N-dimethylformamide is 3:1) , to make a shell spinning solution with a concentration of 0.15 g / mL; dissolve polycaprolactone (PCL) in dichloromethane to form a solution with a concentration of 0.13 g / mL, and add 0.02 g / mL of Centella asiatica Glycosides are formulated as an inner core spinning solution. Add the shell spinning solution and the core spinning solution into two syringes respectively, and connect them to the coaxial electrospinning device through a coaxial needle. When the power supply voltage is 12 kV, the distance between the needle and the receiving substrate is Under the spinning conditions of 13 cm, feeding speed of 0.5 mL / h for the outer layer and 2.0 mL / h for the inner layer, a core / shell nanofiber membrane loaded with asiaticoside was obtained.

Embodiment 2

[0043] Dissolve lactic acid / glycolic acid copolymer (PLGA) in a mixed solution of dichloromethane and N,N-dimethylformamide (the volume ratio of dichloromethane to N,N-dimethylformamide is 3.5:1) , to make a shell spinning solution with a concentration of 0.20 g / mL; dissolve polycaprolactone (PCL) in dichloromethane to form a solution with a concentration of 0.15 g / mL, and add 0.04 g / mL of Centella asiatica Glycosides are formulated as an inner core spinning solution. Add the shell spinning solution and the core spinning solution into two syringes respectively, and connect them to the coaxial electrospinning device through a coaxial needle. When the power supply voltage is 14 kV, the distance between the needle and the receiving substrate is Under the spinning conditions of 14 cm, feeding speed of 0.7 mL / h for the outer layer and 2.4 mL / h for the inner layer, a core / shell nanofiber membrane loaded with asiaticoside was obtained.

Embodiment 3

[0045] Dissolve lactic acid / glycolic acid copolymer (PLGA) in a mixed solution of dichloromethane and N,N-dimethylformamide (the volume ratio of dichloromethane to N,N-dimethylformamide is 4:1) , to make a shell spinning solution with a concentration of 0.23 g / mL; dissolve polycaprolactone (PCL) in dichloromethane to form a solution with a concentration of 0.20 g / mL, and add 0.06 g / mL of Centella asiatica Glycosides are formulated as an inner core spinning solution. Add the shell spinning solution and the core spinning solution into two syringes respectively, and connect them to the coaxial electrospinning device through the coaxial needle. The distance between the needle and the receiving substrate is Under the spinning conditions of 15 cm, feeding speed of 0.9 mL / h for the outer layer and 2.8 mL / h for the inner layer, a core / shell nanofiber membrane loaded with asiaticoside was obtained.

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Abstract

The invention discloses a preparation method and use of a traditional Chinese medicine asiaticoside carrying core / shell structure nanometer fiber film. The traditional Chinese medicine asiaticoside carrying core / shell structure nanometer fiber film is prepared from a lactic acid / glycollic acid copolymer (PLGA) as a shell and polycaprolactone (PCL) as an inner core through a coaxial electrospinning method. The preparation method has the advantages of use of easily available raw materials, operation easiness, good controllability and large scale industrial production easiness. The traditional Chinese medicine asiaticoside carrying core / shell structure nanometer fiber film can be used for wound dressing and has the advantages of controllable drug loading amount, high drug utilization rate and excellent wound healing promoting effect.

Description

technical field [0001] The present invention relates to the preparation of a drug-loaded nanofiber membrane, in particular to a method for preparing a nanofiber membrane with a core / shell structure loaded with the traditional Chinese medicine asiaticoside, and a nanofiber membrane with a core / shell structure loaded with the traditional Chinese medicine asiaticoside. Fibrous membranes are used in medical dressings that promote wound healing. Background technique [0002] The skin is the largest organ in the human body and has a high-level organizational structure. Its functions are to prevent bacterial erosion and infection, protect the human body, regulate body temperature, and excrete body fluids. In addition to the destruction of the skin and tissues, large-scale skin damage may also cause a series of complex pathological and physiological changes in the whole body, such as increased metabolism, excessive loss of water and protein, immune system disorders, etc., and even l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/44A61L15/42A61L15/26D04H1/728D01D5/00D01D5/34
CPCA61L15/26A61L15/42A61L15/44A61L2300/232A61L2300/412D01D5/003D01D5/0069D01D5/0092D01D5/34D04H1/728C08L67/04
Inventor 吕媛媛嵇媛媛顾伟宣贵达沈王兴
Owner 杭州珈晟生物数字技术有限公司
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