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Biomedical adhesive and preparation method thereof

A biomedical and adhesive technology, applied in medical formulations, surgical adhesives, applications, etc., can solve problems such as high adhesive strength, low biocompatibility, and insufficient adhesive strength, and achieve easy-to-obtain raw materials and high-efficiency Good, fast bonding effect

Inactive Publication Date: 2016-11-09
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a biomedical adhesive capable of cross-linking with skin tissue and a preparation method thereof for the low biocompatibility of the existing adhesive and the insufficient adhesive strength in a wet environment. The mixture has good biocompatibility, can be completely degraded and absorbed by the body, has high adhesive strength under wet conditions in the body, and has the functions of filling, sealing and hemostasis, and can promote tissue healing at the same time. It can be used as a medical tissue adhesive, Sealants or hemostats for clinical wound repair

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Preparation of oxidized sodium alginate: Weigh 10g of sodium alginate, disperse it in 25mL of absolute ethanol, then weigh 2g of sodium periodate and dissolve it in 25mL of distilled water in the dark. Stir the reaction for 2 hours in the dark, add 5 mL of ethylene glycol to stop the reaction for 2 hours, and finally put it into a dialysis bag with a molecular weight cut-off of 3,500 Da, dialyze it with distilled water for 3 days, centrifuge the retentate at 10,000 rpm for 30 minutes, remove the precipitate, and remove the supernatant The solution was freeze-dried for 48 hours at a pressure of 20Pa and a temperature of -60°C to obtain oxidized sodium alginate;

[0024] (2) Preparation of oxidized sodium alginate-carboxymethyl chitosan-dopamine biomedical adhesive: Weigh 2.0 g of oxidized sodium alginate prepared in step (1) and dissolve in MES buffer solution with pH 4.5 In the solution, make an oxidized sodium alginate solution with a mass concentration of 2%, then...

Embodiment 2

[0026](1) Preparation of oxidized sodium alginate: Weigh 10g of sodium alginate, disperse it in 50mL of absolute ethanol, then weigh 2g of sodium periodate and dissolve it in 60mL of distilled water in the dark. The reaction was carried out under magnetic stirring in the dark for 4 hours, and 10 mL of ethylene glycol was added to stop the reaction for 1 hour. Finally, it was placed in a dialysis bag with a molecular weight cut-off of 3500 Da, and dialyzed with distilled water for 4 days. The solution was freeze-dried for 60 hours at a pressure of 40 Pa and a temperature of -40°C to obtain oxidized sodium alginate;

[0027] (2) Preparation of oxidized sodium alginate-carboxymethyl chitosan-dopamine biomedical adhesive: Weigh 2.0 g of oxidized sodium alginate prepared in step (1), dissolve in MES buffer solution with pH 5.5 In the solution, make an oxidized sodium alginate solution with a mass concentration of 4%, then add 2g of carboxymethyl chitosan, stir and react at 30°C for...

Embodiment 3

[0029] (1) Preparation of oxidized sodium alginate: Weigh 10g of sodium alginate, disperse it in 100mL of absolute ethanol, then weigh 6g of sodium periodate and dissolve it in 100mL of distilled water in the dark. The reaction was carried out under magnetic stirring in the dark for 10 h, and 20 mL of ethylene glycol was added to terminate the reaction for 0.5 h. Finally, it was placed in a dialysis bag with a molecular weight cut-off of 8000 Da, and dialyzed with distilled water for 5 days. The supernatant was freeze-dried for 72 hours at a pressure of 40Pa and a temperature of -30°C to obtain oxidized sodium alginate;

[0030] (2) Preparation of oxidized sodium alginate-carboxymethyl chitosan-dopamine biomedical adhesive: Weigh 2.0 g of oxidized sodium alginate prepared in step (1), dissolve in MES buffer solution with pH 6.5 In the solution, make an oxidized sodium alginate solution with a mass concentration of 8%, then add 3g of carboxymethyl chitosan, stir and react at 30...

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Abstract

The invention discloses a biomedical adhesive for crosslinking reaction with wound skin tissues and a preparation method thereof. The biomedical adhesive is prepared by a method with following steps of firstly, using sodium periodate and oxidized sodium alginate to prepare dialdehyde sodium alginate, dialyzing, drying, and dissolving a product into an MES (methyl ester sulfonate) buffer solution; then, adding carboxymethyl chitosan, stirring and reacting for 6-12h, sequentially adding a certain amount of N-hydroxy succinimide, 1-(3-dimethylamino propyl)-3-ethylcarbodiimide hydrochloride and dopamine, continuing to stir and react for 8-24h under the nitrogen protection, dialyzing, freeze-drying, and storing in the shade and dry area. Before use, a wound is pretreated by hydrogen peroxide, the freeze-drying adhesive is dissolved by a PBS (poly butylenes succinate) buffer solution, and is immediately coated to the wound, and the wound can be adhered within 2-10min. The biomedical adhesive has the advantages that the adhering strength in the in-vitro wetting environment is stronger, the biocompatibility is good, the biodegradation is realized, and the curing of wounds is effectively promoted.

Description

technical field [0001] The invention relates to a medical wound adhesive with good biocompatibility, biodegradability and strong adhesive force, and functions of filling, sealing and hemostasis, and a preparation and use method thereof, belonging to the field of preparation of biomedical materials. Background technique [0002] Every year, millions of patients in the world need wound suturing due to trauma or surgery. At present, the widely used wound suture method in clinical practice is suture suture. This method sutures firmly and the wound is not easy to dehisce. However, the operation is complicated and the wound is prone to infection. Purulent, easy to scar, and secondary injury to the patient increases the pain of the patient, etc. Therefore, it is necessary to find a medical adhesive to replace the traditional suture method to bond the wound. In fact, people have been using wound adhesives for a long time, and α-cyanoacrylate derivative adhesives have been used as wo...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/00C08G81/00C08B37/00
CPCA61L24/08A61L24/0015A61L24/0031A61L24/0042A61L2300/216A61L2300/412A61L2400/04C08B37/0084C08G81/00C08L87/00
Inventor 但卫华崔国廉但年华
Owner SICHUAN UNIV
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