Biomedical adhesive and preparation method thereof

A biomedical and adhesive technology, applied in medical formulations, surgical adhesives, applications, etc., can solve problems such as high adhesive strength, low biocompatibility, and insufficient adhesive strength, and achieve easy-to-obtain raw materials and high-efficiency Good, fast bonding effect

Inactive Publication Date: 2016-11-09
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a biomedical adhesive capable of cross-linking with skin tissue and a preparation method thereof for the low biocompatibility of the existing adhesive and the insufficient adhesive strength in a wet environment. The mixture has good biocompatibility, ca

Method used

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Examples

Experimental program
Comparison scheme
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Example Embodiment

[0022] Example 1

[0023] (1) Preparation of oxidized sodium alginate: Weigh 10g of sodium alginate, disperse it in 25mL of absolute ethanol, and then weigh 2g of sodium periodate and dissolve it in 25mL of distilled water in the dark, mix the two, and put them at 20℃. The reaction was stirred for 2h under light-shielded magnetic force, 5mL of ethylene glycol was added to terminate the reaction for 2h, and finally put into a dialysis bag with a molecular weight cutoff of 3500Da, dialyzed with distilled water for 3 days, centrifuged the retentate at 10000rpm for 30min to remove the precipitate, and the supernatant The solution is freeze-dried for 48h under the conditions of pressure 20Pa and temperature -60℃ to obtain oxidized sodium alginate;

[0024] (2) Preparation of oxidized sodium alginate-carboxymethyl chitosan-dopamine biomedical adhesive: Weigh 2.0 g of the oxidized sodium alginate prepared in step (1), and dissolve it in a pH 4.5 MES buffer solution In the oxidized sodium...

Example Embodiment

[0025] Example 2

[0026] (1) Preparation of oxidized sodium alginate: Weigh 10g of sodium alginate, disperse it in 50mL of absolute ethanol, and then weigh 2g of sodium periodate and dissolve it in 60mL of distilled water in the dark, mix the two, and put them at 30℃. The reaction was magnetically stirred for 4 hours in the dark, and 10 mL of ethylene glycol was added to terminate the reaction for 1 hour. Finally, it was placed in a dialysis bag with a molecular weight cut-off of 3500 Da, and dialyzed with distilled water for 4 days. The liquid is freeze-dried at a pressure of 40 Pa and a temperature of -40°C for 60 hours to obtain oxidized sodium alginate;

[0027] (2) Preparation of oxidized sodium alginate-carboxymethyl chitosan-dopamine biomedical adhesive: Weigh 2.0 g of oxidized sodium alginate prepared in step (1) and dissolve it in MES buffer solution with pH 5.5 In the oxidized sodium alginate solution with a mass concentration of 4%, 2g of carboxymethyl chitosan was add...

Example Embodiment

[0028] Example 3

[0029] (1) Preparation of oxidized sodium alginate: Weigh 10g of sodium alginate, disperse it in 100mL of absolute ethanol, and then dissolve 6g of sodium periodate in 100mL of distilled water in the dark, mix the two, at 40℃ The reaction was stirred for 10h under light-shielded magnetic force, 20mL ethylene glycol was added to terminate the reaction for 0.5h, and finally put into a dialysis bag with a molecular weight cutoff of 8000Da, dialyzed with distilled water for 5 days, centrifuged the retentate at 20000rpm for 10min to remove the precipitate, The clear liquid was freeze-dried for 72 hours under the conditions of pressure 40 Pa and temperature -30°C to obtain oxidized sodium alginate;

[0030] (2) Preparation of oxidized sodium alginate-carboxymethyl chitosan-dopamine biomedical adhesive: Weigh 2.0g of oxidized sodium alginate prepared in step (1) and dissolve it in MES buffer solution with pH 6.5 In, the oxidized sodium alginate solution with a mass con...

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PUM

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Abstract

The invention discloses a biomedical adhesive for crosslinking reaction with wound skin tissues and a preparation method thereof. The biomedical adhesive is prepared by a method with following steps of firstly, using sodium periodate and oxidized sodium alginate to prepare dialdehyde sodium alginate, dialyzing, drying, and dissolving a product into an MES (methyl ester sulfonate) buffer solution; then, adding carboxymethyl chitosan, stirring and reacting for 6-12h, sequentially adding a certain amount of N-hydroxy succinimide, 1-(3-dimethylamino propyl)-3-ethylcarbodiimide hydrochloride and dopamine, continuing to stir and react for 8-24h under the nitrogen protection, dialyzing, freeze-drying, and storing in the shade and dry area. Before use, a wound is pretreated by hydrogen peroxide, the freeze-drying adhesive is dissolved by a PBS (poly butylenes succinate) buffer solution, and is immediately coated to the wound, and the wound can be adhered within 2-10min. The biomedical adhesive has the advantages that the adhering strength in the in-vitro wetting environment is stronger, the biocompatibility is good, the biodegradation is realized, and the curing of wounds is effectively promoted.

Description

technical field [0001] The invention relates to a medical wound adhesive with good biocompatibility, biodegradability and strong adhesive force, and functions of filling, sealing and hemostasis, and a preparation and use method thereof, belonging to the field of preparation of biomedical materials. Background technique [0002] Every year, millions of patients in the world need wound suturing due to trauma or surgery. At present, the widely used wound suture method in clinical practice is suture suture. This method sutures firmly and the wound is not easy to dehisce. However, the operation is complicated and the wound is prone to infection. Purulent, easy to scar, and secondary injury to the patient increases the pain of the patient, etc. Therefore, it is necessary to find a medical adhesive to replace the traditional suture method to bond the wound. In fact, people have been using wound adhesives for a long time, and α-cyanoacrylate derivative adhesives have been used as wo...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/00C08G81/00C08B37/00
CPCA61L24/08A61L24/0015A61L24/0031A61L24/0042A61L2300/216A61L2300/412A61L2400/04C08B37/0084C08G81/00C08L87/00
Inventor 但卫华崔国廉但年华
Owner SICHUAN UNIV
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