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A kind of ciprofloxacin hydrochloride sustained-release microcapsules for animals and preparation method thereof

A technology for ciprofloxacin hydrochloride and animals, which is applied in the direction of microcapsules, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of reducing animal morbidity, unsatisfactory conditions, and affecting treatment effects, etc. problems, to achieve the effects of prolonging the average residence time, good palatability, and good sustained-release effect

Active Publication Date: 2019-08-16
WUHAN HUAYANG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the continuous development of intensive farming, the individual administration method of injection is increasingly unable to meet the actual production needs. Compared with injection, oral administration is simple and flexible, which can not only save costs, but also reduce animal stress. stimulation, thereby reducing the morbidity in animals
Its hydrochloride is often used in veterinary clinics, but the palatability of ciprofloxacin hydrochloride is poor, and the administration of spices will affect the animal's feed intake, resulting in low animal drug intake, and the drug cannot reach the effective blood concentration in the body, affecting the therapeutic effect

Method used

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  • A kind of ciprofloxacin hydrochloride sustained-release microcapsules for animals and preparation method thereof
  • A kind of ciprofloxacin hydrochloride sustained-release microcapsules for animals and preparation method thereof
  • A kind of ciprofloxacin hydrochloride sustained-release microcapsules for animals and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A kind of preparation method of animal-specific ciprofloxacin hydrochloride sustained-release microcapsules

[0036] (1) 90kg of stearic acid is melted in a 70°C water bath, 15kg of ciprofloxacin hydrochloride is added, stirred and evenly mixed, the molten material is spread out to condense, solidify, pulverize, and sieve to obtain the core material;

[0037] (2) Dissolve 4.0kg Eudragit E 100 (copolymer of butyl methacrylate, dimethylaminoethyl methacrylate and methyl methacrylate (1:2:1)) in 200L purified water to obtain 2% Eudragit E 100 coating liquid;

[0038] (3) The core material and the coating solution were mixed, and then spray-dried. The spray-drying inlet air temperature was 110° C., the outlet air temperature was 55° C., and the flow rate was 5 mL / min to obtain microencapsulated ciprofloxacin hydrochloride.

[0039] The obtained ciprofloxacin hydrochloride sustained-release microcapsules have stable physical and chemical properties, and the drug loading and...

Embodiment 2

[0042] A kind of preparation method of animal-specific ciprofloxacin hydrochloride sustained-release microcapsules

[0043] (1) Melting 90kg of stearic acid in a 70°C water bath, adding 10kg of ciprofloxacin hydrochloride, stirring and mixing, the molten material is spread out to condense, solidify, pulverize, and sieve to obtain the core material;

[0044] (2) Dissolve 4.0kg Eudragit E 100 (copolymer of butyl methacrylate, dimethylaminoethyl methacrylate and methyl methacrylate (1:2:1)) in 200L purified water to obtain 2% Eudragit E 100 coating solution;

[0045] (3) The core material and the coating solution were mixed, and then spray-dried. The spray-drying inlet air temperature was 110° C., the outlet air temperature was 55° C., and the flow rate was 5 mL / min to obtain microencapsulated ciprofloxacin hydrochloride.

[0046] The obtained ciprofloxacin hydrochloride sustained-release microcapsules have stable physical and chemical properties, and the drug loading and encaps...

Embodiment 3

[0049] A kind of preparation method of animal-specific ciprofloxacin hydrochloride sustained-release microcapsules

[0050] (1) 90kg of stearic acid is melted in a 70°C water bath, 18kg of ciprofloxacin hydrochloride is added, stirred and evenly mixed, the melted material is spread out to condense, solidify, pulverize, and sieved to obtain a core material;

[0051] (2) Dissolve 4kg Eudragit E 100 (copolymer of butyl methacrylate, dimethylaminoethyl methacrylate and methyl methacrylate (1:2:1)) in 200L purified water to obtain 2 % Eudragit E 100 coating solution;

[0052] (3) The core material and the coating solution were mixed, and then spray-dried. The spray-drying inlet air temperature was 110° C., the outlet air temperature was 55° C., and the flow rate was 5 mL / min to obtain microencapsulated ciprofloxacin hydrochloride.

[0053] The obtained ciprofloxacin hydrochloride sustained-release microcapsules have stable physical and chemical properties, and the drug loading and...

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PUM

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Abstract

The invention discloses a ciprofloxacin hydrochloride slow-release microcapsule for animals, which comprises a core material and a packaging material coated outside the core material, wherein the core material contains the following components: stearic acid and ciprofloxacin hydrochloride; The packaging material contains Eudragit E100. The present invention uses stearic acid as the erodible framework material, uses acrylic resin (Udragit 100) as the packaging material, and adopts spray drying technology to coat ciprofloxacin hydrochloride to solve the problem of palatability of the medicine, so as to better Meet veterinary clinical use.

Description

technical field [0001] The invention belongs to the technical field of preparation of animal medicines, and in particular relates to a fluoroquinolone antibacterial drug ciprofloxacin hydrochloride slow-release microcapsules for animals and a preparation method thereof. Background technique [0002] Ciprofloxacin is a fluoroquinolone antibiotic with a broad antibacterial spectrum. The antibacterial activity against Gram-negative bacteria is the strongest among the fluoroquinolones currently used in veterinary medicine; the effect on Gram-negative bacteria is also strong. In addition, it also has a strong antibacterial effect on mycoplasma anaerobic bacteria and Pseudomonas aeruginosa. It is used for infections in various systems of the body, and has good effects on digestive tract, respiratory tract, genitourinary tract, skin and soft tissue infection and mycoplasma infection. The dosage forms used clinically in veterinary medicine include injections and premixes. However...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K47/12A61K47/32A61K31/496A61P31/04
CPCA61K9/5026A61K31/496A61K47/12
Inventor 张金林马立保肖飞吴晓明刘丽娜陈莉吴艳丽多婷黄燕黄煌
Owner WUHAN HUAYANG ANIMAL PHARMA
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