Method for preparing three-dimensional paper chip based on multi-edition patterning and silk screen combined printing technology

A printing technology, screen printing technology, applied in the direction of chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve the problems of complex production process, high cost, low precision, etc., and achieve simple equipment and improved The effect of precision and simplification of production steps

Inactive Publication Date: 2016-11-16

DALIAN UNIVERSITY

6 Cites 11 Cited by

AI-Extracted Technical Summary

Problems solved by technology

[0010] For this reason, the present invention aims at the deficiencies of the above-mentioned problems, and provides a method for preparing three-dimensional paper chips based ...

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Abstract

The invention provides a method for preparing a three-dimensional paper chip based on a multi-edition patterning and silk screen combined printing technology. The method comprises the following specific preparation procedures: printing a hydrophobic printing solution on paper through a patterned ink-printing silk screen by a scraper so as to allow the hydrophobic printing solution to permeate through the paper and form a hydrophobic area, and taking an unprinted part as a hydrophilic area, so as to obtain a channel layer and a detection layer of the paper chip; printing a pretreating reagent on pretreatment areas of the channel layer and the detection layer through a patterned reagent-printing silk screen by a scraper; printing a detection reagent on a detection area of the detection layer through the patterned reagent-printing silk screen by a scraper; printing a glue solution on the channel layer through a patterned glue-printing silk screen by a scraper; and binding and assembling the channel layer and the detection layer, thereby obtaining the three-dimensional paper chip. According to the method provided by the invention, the process is simple, patterning is easy to realize, the accuracy of pattern making is high, instruments and equipment are simple, industrialization is easy to achieve, and the production cost is reduced remarkably.

Application Domain

Laboratory glasswares

Technology Topic

EngineeringInstrumentation +3

Image

Examples

Experimental program(8)

Example Embodiment

[0038] Example 1

[0039] Select 300 mesh patterned printing ink screen, the material is nylon, the screen tension is 18N/cm, and use this patterned printing ink screen to make hydrophobic printing composed of 3:1 screen printing ink and ethyl acetate. Liquid, printed on filter paper, the screen distance between the ink screen and the filter paper during printing is 1.5mm, the contact angle of the scraper and the ink screen is 45°, the printing speed is 0.2m/s, the paper The pressure is 12N to obtain the channel layer and detection layer of the paper chip (2D paper chip).

[0040] The pretreatment agent uses a chemical masking agent, specifically sodium malonate with a mass ratio of 20% and 15% sodium fluoride. Use a mixed solution of EDTA and HF (EDTA: 0.05 mol l) as the color developing agent sodium diethyldithiocarbamate -1; HF: 0.05mol l -1 ) Configure to 1.0mg ml -1 Use 2% (v/v) ammonia water to adjust the pH to 8.5 to obtain the detection agent.

[0041] Select 400-mesh patterned printing drug screen, its material is nylon, the screen tension is 18N/cm; use the patterned printing drug screen to print the above pretreatment agent on figure 1 In the pretreatment area of the second layer as shown, the detection agent obtained above is printed on figure 1 The detection area of the fourth layer shown, dry, and its screen patterns are the same as those of the second and fourth layers. The screen distance between the printing screen and the filter paper is 1.5mm during printing. The scraper and the printing screen The contact angle is 45°, the printing speed is 0.4m/s, and the paper pressure is 8N.

[0042] Select a 150-mesh patterned printing drug screen, the material is steel mesh, the screen tension is 15N/cm, and the patterned printing screen is used to print the glue (paper viscose whose main component is epoxy resin) on the figure 1 The back side of the first layer, the back side of the second layer and the front side of the fourth layer are shown. The screen patterns are the same as those of the first layer, second layer and fourth layer. When printing, the glue screen and filter paper are printed between The screen distance is 1.5mm, the contact angle of the squeegee and the printing screen is 45°, the printing speed is 0.4m/s, the pressure of the paper is 4N, and the back of the first layer of filter paper is bonded to the front of the second layer of filter paper. Bonding to the entire patterned three-dimensional paper chip assembly is completed.

[0043] The paper penetration rate of the hydrophobic material of the 2D chip is 100%, the channel resolution is 0.25mm, and the glue has no effect on the hydrophilicity of the channel. The structure diagram of the three-dimensional paper chip prepared according to the above steps is as figure 1 Shown. Through this chip, a single sample can be divided into 16 parallel samples in parallel, increasing the detection throughput.

Example Embodiment

[0044] Example 2

[0045] Select 400 mesh patterned printing ink screen, the material is nylon, the screen tension is 18N/cm, and use this patterned printing ink screen to print a hydrophobic printing liquid composed of acrylic pigment and ethanol with a volume ratio of 1:1. On filter paper, the screen distance between the ink screen and the filter paper during printing is 1.5mm, the contact angle of the squeegee and the ink screen is 45°, the printing speed is 0.2m/s, and the pressure on the paper is 12N, obtain the channel layer and detection layer of the paper chip (2D paper chip).

[0046] The pretreatment agent uses a chemical masking agent, specifically Na 2 S 2 O 3 (40ppm) and 0.05%(v/v)H 2 SO 4 The mixed solution. Use 50% (v/v) acetone aqueous solution to make 2mg ml of color developer diacetyl oxime -1 Solution (the solution also contains EDTA: 0.05mol l -1 , Na 2 S 2 O 3 :0.05mol l -1 ), get the detection agent.

[0047] Select 400 mesh patterned drug printing screen, its material is nylon, the screen tension is 18N/cm, and use the patterned drug screen to print the above-mentioned pretreatment agent on figure 2 As shown in the second or third layer pretreatment area, the detection drug is printed on figure 2 The detection area of the fourth layer shown, dry, and its screen patterns are the same as those of the second and fourth layers. The screen distance between the printing screen and the filter paper is 1.5mm during printing. The scraper and the printing screen The contact angle is 45°, the printing speed is 0.4m/s, and the paper pressure is 8N.

[0048] Select a 150-mesh patterned printing drug screen, the material is steel mesh, the screen tension is 15N/cm, and the patterned printing screen is used to print the glue (paper viscose whose main component is epoxy resin) on the figure 2 The back side of the first layer, the back side of the second layer and the front side of the fourth layer are shown. The screen patterns are the same as those of the first layer, second layer and fourth layer. When printing, the glue screen and filter paper are printed between The screen distance is 1.5mm, the contact angle of the squeegee and the printing screen is 45°, the printing speed is 0.4m/s, the pressure of the paper is 4N, and the back of the first layer of filter paper is bonded to the front of the second layer of filter paper. Bonding to the entire patterned three-dimensional paper chip assembly is completed.

[0049] The paper penetration rate of the hydrophobic material of the 2D chip is 100%, the channel resolution is 0.125mm, and the glue has no effect on the hydrophilicity of the channel layer. The structure diagram of the three-dimensional paper chip prepared according to the above steps is as follows figure 2 Shown. Through this chip, 4 kinds of samples to be tested can be divided into 4 parallel samples respectively, and form figure 2 The arrangement of the detection array in the

Example Embodiment

[0050] Example 3

[0051] Select 200 mesh patterned printing ink screen, the material is nylon, the screen tension is 15N/cm, and the hydrophobic printing liquid composed of paraffin wax and n-heptane with a mass ratio of 1:150 is used for printing. On the cellulose acetate film, the screen distance between the ink screen and the cellulose acetate film during printing is 1.8mm, the angle when the squeegee is in contact with the ink screen is 40°, and the printing speed is 0.6m/ s, the cellulose acetate membrane is subjected to a pressure of 4N to obtain the channel layer and detection layer of the paper chip (2D paper chip).

[0052] The pretreatment agent is ammonia water with a volume fraction of 2%, and the detection agent is diacetyl oxime with a concentration of 2 mg/ml.

[0053] Select 300-mesh patterned printing drug screen, its material is nylon, the screen tension is 15N/cm; use the patterned printing drug screen to print the above pretreatment agent on figure 1 As shown in the second layer pretreatment area, the above detection agent is printed on figure 1 The detection area of the fourth layer shown is dried, and its screen patterns are the same as those of the second and fourth layers. The screen distance between the printing medicine screen and the cellulose acetate film is 1.8mm during printing. The contact angle of the medical screen is 40°, the printing speed is 0.4m/s, and the pressure of the cellulose acetate membrane is 8N.

[0054] Choose a 160-mesh patterned printing drug screen, the material is steel mesh, the screen tension is 18N/cm, and the patterned printing screen is used to print the glue (paper viscose whose main component is epoxy resin) on the figure 1 The back side of the first layer, the back side of the second layer and the front side of the fourth layer are shown. The screen patterns are the same as those of the first layer, second layer and fourth layer. When printing, the glue screen and cellulose acetate are printed. The screen distance between the films is 1.8mm, the contact angle of the squeegee and the printing screen is 40°, the printing speed is 0.6m/s, the pressure of the cellulose acetate film is 8N, and the back of the first layer of cellulose acetate film is The second layer of cellulose acetate film is bonded on the front side, and then bonded to the entire patterned three-dimensional paper chip in order to complete the assembly.

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PUM

Property	Measurement	Unit
Tension	15.0 ~ 18.0	N/cm
Under pressure	8.0	N
tensile		MPa
Particle size		Pa
strength	10

Description & Claims & Application Information

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the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine

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Classification and recommendation of technical efficacy words

Easy to make

Method for preparing three-dimensional paper chip based on multi-edition patterning and silk screen combined printing technology

AI-Extracted Technical Summary

Problems solved by technology

Abstract

Image

Examples

Example Embodiment

Example Embodiment

Example Embodiment

PUM

Description & Claims & Application Information

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