Method for preparing three-dimensional paper chip based on multi-edition patterning and silk screen combined printing technology

A printing technology, screen printing technology, applied in the direction of chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve the problems of complex production process, high cost, low precision, etc., and achieve simple equipment and improved The effect of precision and simplification of production steps

Inactive Publication Date: 2016-11-16
DALIAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] For this reason, the present invention aims at the deficiencies of the above-mentioned problems, and provides a method for preparing three-dimensional paper chips based

Method used

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  • Method for preparing three-dimensional paper chip based on multi-edition patterning and silk screen combined printing technology
  • Method for preparing three-dimensional paper chip based on multi-edition patterning and silk screen combined printing technology

Examples

Experimental program
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Example Embodiment

[0038] Example 1

[0039] Select 300 mesh patterned printing ink screen, the material is nylon, the screen tension is 18N / cm, and use this patterned printing ink screen to make hydrophobic printing composed of 3:1 screen printing ink and ethyl acetate. Liquid, printed on filter paper, the screen distance between the ink screen and the filter paper during printing is 1.5mm, the contact angle of the scraper and the ink screen is 45°, the printing speed is 0.2m / s, the paper The pressure is 12N to obtain the channel layer and detection layer of the paper chip (2D paper chip).

[0040] The pretreatment agent uses a chemical masking agent, specifically sodium malonate with a mass ratio of 20% and 15% sodium fluoride. Use a mixed solution of EDTA and HF (EDTA: 0.05 mol l) as the color developing agent sodium diethyldithiocarbamate -1 ; HF: 0.05mol l -1 ) Configure to 1.0mg ml -1 Use 2% (v / v) ammonia water to adjust the pH to 8.5 to obtain the detection agent.

[0041] Select 400-mesh patt...

Example Embodiment

[0044] Example 2

[0045] Select 400 mesh patterned printing ink screen, the material is nylon, the screen tension is 18N / cm, and use this patterned printing ink screen to print a hydrophobic printing liquid composed of acrylic pigment and ethanol with a volume ratio of 1:1. On filter paper, the screen distance between the ink screen and the filter paper during printing is 1.5mm, the contact angle of the squeegee and the ink screen is 45°, the printing speed is 0.2m / s, and the pressure on the paper is 12N, obtain the channel layer and detection layer of the paper chip (2D paper chip).

[0046] The pretreatment agent uses a chemical masking agent, specifically Na 2 S 2 O 3 (40ppm) and 0.05%(v / v)H 2 SO 4 The mixed solution. Use 50% (v / v) acetone aqueous solution to make 2mg ml of color developer diacetyl oxime -1 Solution (the solution also contains EDTA: 0.05mol l -1 , Na 2 S 2 O 3 :0.05mol l -1 ), get the detection agent.

[0047] Select 400 mesh patterned drug printing screen, its...

Example Embodiment

[0050] Example 3

[0051] Select 200 mesh patterned printing ink screen, the material is nylon, the screen tension is 15N / cm, and the hydrophobic printing liquid composed of paraffin wax and n-heptane with a mass ratio of 1:150 is used for printing. On the cellulose acetate film, the screen distance between the ink screen and the cellulose acetate film during printing is 1.8mm, the angle when the squeegee is in contact with the ink screen is 40°, and the printing speed is 0.6m / s, the cellulose acetate membrane is subjected to a pressure of 4N to obtain the channel layer and detection layer of the paper chip (2D paper chip).

[0052] The pretreatment agent is ammonia water with a volume fraction of 2%, and the detection agent is diacetyl oxime with a concentration of 2 mg / ml.

[0053] Select 300-mesh patterned printing drug screen, its material is nylon, the screen tension is 15N / cm; use the patterned printing drug screen to print the above pretreatment agent on figure 1 As shown in...

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Abstract

The invention provides a method for preparing a three-dimensional paper chip based on a multi-edition patterning and silk screen combined printing technology. The method comprises the following specific preparation procedures: printing a hydrophobic printing solution on paper through a patterned ink-printing silk screen by a scraper so as to allow the hydrophobic printing solution to permeate through the paper and form a hydrophobic area, and taking an unprinted part as a hydrophilic area, so as to obtain a channel layer and a detection layer of the paper chip; printing a pretreating reagent on pretreatment areas of the channel layer and the detection layer through a patterned reagent-printing silk screen by a scraper; printing a detection reagent on a detection area of the detection layer through the patterned reagent-printing silk screen by a scraper; printing a glue solution on the channel layer through a patterned glue-printing silk screen by a scraper; and binding and assembling the channel layer and the detection layer, thereby obtaining the three-dimensional paper chip. According to the method provided by the invention, the process is simple, patterning is easy to realize, the accuracy of pattern making is high, instruments and equipment are simple, industrialization is easy to achieve, and the production cost is reduced remarkably.

Description

technical field [0001] The invention relates to the field of preparation of three-dimensional paper chips, in particular to a method for preparing three-dimensional paper chips based on multi-version patterned screen joint printing technology. Background technique [0002] Microfluidic paper chip, also known as micro-lab on paper, is a new type of microfluidic analysis device that realizes analysis and detection by constructing a fluid channel network on a paper substrate. It combines the miniaturization and portability of traditional microfluidic chips with the advantages of cheap and easy-to-obtain filter paper, convenient processing, and good biocompatibility. It has become a brand-new analysis technology platform. And environmental quality monitoring and other fields have shown good application prospects. [0003] (1) 2D paper chip processing technology [0004] At present, the 2D paper chip processing technologies reported in the literature include UV lithography, wax...

Claims

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Application Information

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IPC IPC(8): B01L3/00
CPCB01L3/5027B01L3/502707B01L2200/10B01L2200/12B01L2300/0874B01L2300/126B01L2300/161
Inventor 王云华郑国侠李雅杰
Owner DALIAN UNIVERSITY
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