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Application of medicinal nano-material composition DG-5 to resistance of drug resistant bacteria

A technology of nanomaterials and compositions, applied in the field of medicine, can solve the problems such as limiting the application of nanosilver materials, anti-super-resistant bacteria of nanosilver, and the influence of reducing agents, etc. have not yet been seen

Inactive Publication Date: 2016-12-07
CHANGSHA DIGU NANO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the preparation process, the usual physical methods (such as ball milling) are difficult to reach the nanoscale
The electrolysis method has low output and high cost, and is not suitable for industrial application
However, the preparation of chemical methods has always been confusing for obtaining high-purity nano-powder products. Especially in the process of industrialization, the separation of various "acid radicals" and the removal of impurities are extremely difficult to achieve. In addition, there is also the influence of reducing agents.
Thereby limiting the application of nano-silver materials in various fields, especially in the fields of biology and medicine
So far, there has been no report on the anti-super-resistant bacteria of nano-silver

Method used

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  • Application of medicinal nano-material composition DG-5 to resistance of drug resistant bacteria
  • Application of medicinal nano-material composition DG-5 to resistance of drug resistant bacteria
  • Application of medicinal nano-material composition DG-5 to resistance of drug resistant bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023]Embodiment 1: pharmaceutical nanomaterial composition DG-5, is made up of the composition of following concentration: spherical nano-silver powder 1-2g / L, glucose 1-2g / L, all the other are water; Described spherical nano-silver powder particle size 0.1-5nm (purchased from Hunan Optics Valley Nano Technology Co., Ltd.), the purity of silver in the spherical nano-silver powder is ≥99.99%.

Embodiment 2

[0024] Example 2: Determination of the activity of the pharmaceutical nanomaterial composition DG-5 against 5 strains of drug-resistant bacteria (Klebsiella pneumoniae, Acinetobacter calcoaceticus, Enterococcus faecalis, Streptococcus pneumoniae, Staphylococcus aureus).

[0025] In this study, the minimum inhibitory concentration was used as the index of antibacterial activity. The minimum inhibitory concentration refers to the lowest compound concentration (Minimum inhibitory concentration, MIC) that can inhibit the growth of a certain microorganism. The minimum inhibitory concentration was determined with reference to the micro-medium dilution method of the Clinical and Laboratory Standards Institute Guidelines (CLSI). In this study, the minimum inhibitory concentrations of a test sample DG-5 and a control antibiotic ciprofloxacin against 5 strains of bacteria were tested. The test sample DG-5 was diluted two-fold from the highest detection concentration of 30 μg / ml in a 96...

Embodiment 3

[0048] Example 3: Determination of the activity of the pharmaceutical nanomaterial composition DG-5 against 5 strains of super drug-resistant bacteria.

[0049] Using the same method as in Example 2, the pharmaceutical nanomaterial composition DG-5 is resistant to 5 strains of super drug-resistant bacteria (Enterobacter cloacae, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Baumannii Bacteria) activity was measured. The minimum inhibitory concentration of the reference substance ciprofloxacin tested together is consistent with the historical data, and it is finally determined that the minimum inhibitory concentration of the test sample DG-5 against 5 strains of bacteria is between 1.875-3.75μg / ml, which is far better than the positive Antibacterial activity of the control drug ciprofloxacin.

[0050] 1. Materials

[0051] bacterial strain

[0052] bacterial species

Gram stain classification

Numbering

Enterobacter cloacae

G-

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Abstract

Them invention belongs to the technical field of medicines and relates to preparation of a medicinal nano-material composition DG-5 and application thereof to resistance of drug resistant bacteria. The nano-material composition DG-5 has a very high inhibition effect on a plurality of types of superbugs, and can be used for preparing a novel effective antibacterial medicine. The medicine can be used through administration routes inducing external utilization, oral administration, subcutaneous injection, intravenous injection, intramuscular injection and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the preparation of a pharmaceutical nano-silver composition DG-5 and its use in anti-drug-resistant bacteria drugs, including the treatment of methicillin-resistant Staphylococcus aureus (Methicillin-Resistant Staphylococcus Aureus, MRSA) and Vancomycin-resistant Enterococcus (VRE), especially against Superbugs such as Enterobacter cloacae, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii Effect. Background technique [0002] In recent years, the continuous increase of antibiotic-resistant strains has seriously threatened public health. As early as the 1940s, penicillin, as the first effective antibiotic, successfully solved the clinical problem of Staphylococcus aureus infection. Subsequently, various antibiotics such as macrolides and aminoglycosides were successfully developed, which greatly reduced the mortality rate of fatal disea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K47/26A61P31/04
CPCA61K33/38A61K47/26A61K9/0019A61K9/0053A61K9/10A61P31/04Y02A50/30A61K9/16
Inventor 刘进军李强柏司徒健超
Owner CHANGSHA DIGU NANO BIOTECH
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