Method for determination of acetaldehyde in electronic cigarette liquid
A technology of e-cigarette liquid and determination method, which is applied to measurement devices, instruments, scientific instruments, etc., can solve the problems of large differences in substrates, large differences in additives, and complex substrates of e-cigarette liquids, so as to prevent aggregation, Good solubility, good solubility effect
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example 1
[0032] Acetaldehyde-2,4-dinitrophenylhydrazone standard solution was analyzed by LC-MS / MS. Perform regression analysis on the peak area ratio of the target substance and internal standard quantitative ion pair and the concentration of acetaldehyde to obtain the standard working curve and regression equation of acetaldehyde, and calculate the limit of detection (LOD) with 3 times the signal-to-noise ratio (S / N = 3), The specific test results are shown in Table 2:
[0033] Table 2 Test results of acetaldehyde standard working solution
[0034] compound
example 2
[0036] The standard addition recovery experiment was carried out at three concentration levels of low, medium and high. Each standard addition level was repeated 5 times, and the recovery rate and precision of each addition level were calculated according to the measured amount and the standard addition amount. The specific results are shown in the following table:
[0037] Table 3 method recovery and repeatability
[0038]
example 3
[0040]Weigh 0.2 g of an e-cigarette liquid sample, add 0.6-3.0 mL deionized water, 0.4-3.0 mL DNPH derivatization reagent and 50-500 µL HClO 4 Aqueous solution, shake well, place at room temperature for 30-150 min for derivatization reaction, add 50-500 µL pyridine after the reaction, add 100 µL internal standard working solution, and dilute to 10 mL with acetonitrile, shake well, pass through 0.22 µm organic phase filter membrane, into LC-MS / MS analysis.
[0041] Substituting the peak area ratio of the target substance and the internal standard quantitative ion pair into the regression equation, the acetaldehyde content in the sample was calculated to be 4.06 µg / g.
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