Phthalazinone derivative and preparation method thereof, and catalyst used for preparation of phthalazinone derivative

Abstract

The invention discloses a phthalazinone derivative and a preparation method thereof, and a catalyst used for preparation of the phthalazinone derivative, belonging to the technical field of ionic liquid catalysis. According to the invention, a mol ratio of aromatic aldehyde to succinic anhydride to 5,5-dimethyl-1,3-cyclohexanedione to hydrazine hydrate is 1: 1: 1: (1.0-1.2); the molar weight of an ionic liquid catalyst is 8 to 15% of the molar weight of aromatic aldehyde; the volume dose of a reaction solvent aqueous ethanol solution in terms of milliliter is 5 to 8 times of the molar weight of aromatic aldehyde in terms of millimole; reflux time is 21 to 53 min; after completion of the reaction, cooling to room temperature and pumping filtration are successively carried out; and a filter residue is subjected to washing and vacuum drying so as to obtain 3,4,7,8-tetrahydro-3,3-dimethyl-11-aryl-2H-phthalizine[1,2-alpha]-indolo-1,6,9(11H)-trione. The invention has the characteristics that the catalyst is high in activity; reaction time is short; the prepared derivative is simple to purify; the raw materials are high in utilization rate; the whole preparation process is simple and convenient in operation; etc.; so the preparation method is suitable for industrial large-scale application.

Description

technical field [0001] The invention belongs to the technical field of ionic liquid catalysis, and more specifically relates to a phthalazinone derivative, a preparation method of the derivative and a catalyst for preparation thereof. Background technique [0002] Phthalazinone compounds are a class of six-membered nitrogen-containing heterocyclic rings with good biological activity, which occupy an important position in the research and development of medicine and pesticides. In terms of pesticides, pesticides related to phthalazinone compounds are widely used, such as insecticides, herbicides, plant growth regulators, fungicides, etc.; in terms of medicine, phthalazinone compounds can be used as cyclooxygenase inhibitors , calcium sensitizers and phosphodiesterase inhibitors, etc., and can be used for the treatment of related diseases. [0003] Among them, the multi-component synthesis method is the most important method for the synthesis of phthalazinone derivatives. It ...

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Problems solved by technology

[0007] The purpose of the present invention is to overcome the low utilization rate of raw materials, long reaction time, complex product purification process, large amount of ionic liquid catalyst used, and catalyst phthalazinone derivatives in the prior art when using acidic ionic liquid to catalyze the four-component reaction to prepare phthalazinone derivatives The loss in the circulation process is large, which leads to the disadvantages of less recycling times and the need for a series of treatments before the catalyst is recycled. A phthalazinone derivative, a preparation method of the derivative and a catalyst for its preparation are provided.

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