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Determination method of acraldehyde in electronic cigarette smoke solution

A technology of e-cigarette liquid and measurement method, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of large differences in additives, complex matrix of e-cigarette liquid, and large difference in matrix, and achieve good solubility , good solubility, anti-polymerization effect

Inactive Publication Date: 2016-12-21
ZHENGZHOU TOBACCO RES INST OF CNTC
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, due to the wide variety of e-liquid brand specifications and the large differences in the additives of different flavors of e-liquid, the e-liquid matrix is ​​relatively complex, and the matrix of different e-liquid samples varies greatly

Method used

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  • Determination method of acraldehyde in electronic cigarette smoke solution
  • Determination method of acraldehyde in electronic cigarette smoke solution
  • Determination method of acraldehyde in electronic cigarette smoke solution

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0031] Acrolein-2,4-dinitrophenylhydrazone standard solution was analyzed by LC-MS / MS. Regression analysis was performed on the peak area ratio of the target substance and the internal standard quantitative ion pair and the acrolein concentration to obtain the acrolein standard working curve and regression equation. The limit of detection (LOD) was calculated by 3 times the signal-to-noise ratio (S / N = 3), The specific test results are shown in Table 2:

[0032] Table 2 Test results of acrolein standard working solution

[0033] compound

example 2

[0035] The standard addition recovery experiment was carried out at three concentration levels of low, medium and high. Each standard addition level was repeated 5 times, and the recovery rate and precision of each addition level were calculated according to the measured amount and the standard addition amount. The specific results are shown in the following table:

[0036] Table 3 method recovery and repeatability

[0037]

example 3

[0039] Weigh 0.2 g of an e-cigarette liquid sample, add 0.6-3.0 mL deionized water, 0.4-3.0 mL DNPH derivatization reagent and 50-500 µL HClO 4 Aqueous solution, shake well, place at room temperature for 30-150 min for derivatization reaction, add 50-500 µL pyridine after the reaction, add 100 µL internal standard working solution, and dilute to 10 mL with acetonitrile, shake well, pass through 0.22 µm organic phase filter membrane, into LC-MS / MS analysis.

[0040] Substituting the peak area ratio of the target substance and the internal standard quantitative ion pair into the regression equation, the acrolein content in the sample was calculated to be 0.28 μg / g.

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Abstract

The invention relates to a rapid analysis and determination method for acrolein in electronic cigarette liquid, comprising the following steps: firstly adding a dispersant to the electronic cigarette liquid sample, then adding a DNPH derivatization reagent and an acidic solution to carry out a derivatization reaction, and then Add an alkaline reagent and an internal standard, and finally use LC-MS / MS to analyze and determine the acrolein content in the e-cigarette liquid. The method has high sensitivity, strong anti-interference, good repeatability, and the pretreatment process is simple and fast, and is suitable for the detection of large quantities of e-cigarette liquid samples.

Description

technical field [0001] The invention relates to a rapid analysis and determination method for acrolein in electronic cigarette liquid, belonging to the technical field of trace analysis. Background technique [0002] The appearance of acrolein is colorless or light yellow liquid, which is a highly toxic substance, LD 50 46 mg / kg (rat oral); minimum lethal dose: 5 mg / kg human oral. Strong irritant, inhalation of steam damages the respiratory tract, pharyngitis, chest pressure, bronchitis; large inhalation can cause pneumonia, pulmonary edema, shock, nephritis and heart failure. Liquid and vapor damage eyes, skin contact can cause burns. In 1988, the US Environmental Protection Agency (Environmental Protection Agency) listed it as a harmful air pollutant and focused on its carcinogenicity. In the same year, acrolein was included in the list of harmful ingredients in cigarettes by the Canadian government. However, up to now, there is not enough evidence to show that acrole...

Claims

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Application Information

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IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 潘立宁赵乐刘克建彭斌陈黎余晶晶刘绍锋樊美娟贾云祯刘惠民孟庆华
Owner ZHENGZHOU TOBACCO RES INST OF CNTC
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