Black phosphorus wrapped with polymer as well as preparation method and application thereof

A technology of polymer and black phosphorus, which can be used in medical preparations without active ingredients, medical preparations containing active ingredients, and drug combinations, etc., can solve the problems of inability to protect anti-oxidation and stability of black phosphorus.

Active Publication Date: 2017-01-04
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method of covering the surface of black phosphorus with metal oxides to reduce the contact of black phosphorus on the surface with air and moisture cannot protect the black phosphorus on the side and only has a certain anti-oxidation effect in the air. However, the stability when applied in solution or physiological environment still needs to be solved.

Method used

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  • Black phosphorus wrapped with polymer as well as preparation method and application thereof
  • Black phosphorus wrapped with polymer as well as preparation method and application thereof
  • Black phosphorus wrapped with polymer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078]The present embodiment provides a kind of PLGA-wrapped black phosphorus quantum dots and a preparation method thereof, the method comprising the following steps:

[0079] (1) Preparation of black phosphorus quantum dots: Weigh 25 mg of black phosphorus block in a nitrogen-filled glove box, grind it and disperse it into 25 mL of N-methylpyrrolidone and seal it to obtain a 1 mg / mL dispersion ; Sonicate for 3 hours under 1200W probe ultrasonic power, and then immediately ultrasonicate for 10 hours in a water bath with 300W power. The whole ultrasonic process is completed under the condition that the stability is controlled below 277K by ice bath; Centrifuge at a speed of 1 / min for 20 minutes, take the supernatant, and obtain small-sized black phosphorus quantum dots (concentration 1-100 μg / mL) dispersed in N-methylpyrrolidone.

[0080] The black phosphorus quantum dot solution prepared above was dropped on the carbon-coated copper grid with filter paper as the bottom, and a...

Embodiment 2

[0087] The photothermal therapy effect of the PLGA-wrapped black phosphorus quantum dots prepared in Example 1 on tumor cells was tested, and the cell apoptosis was detected by the Calcein-AM / PI live cell / dead cell double staining method. The specific steps are as follows: Digest logarithmically growing breast cancer cells (MCF7) from the culture flask with trypsin (1:250) to make a cell suspension and adjust the cell density to 5×10 4 cells / mL. Add 1 mL of cell suspension to each well of a 12-well plate, and add 5% volume fraction of CO 2 Culture in an incubator at 37°C. When the cell monolayer covered the bottom of the 24-well plate, the PBS solutions of PLGA-wrapped black phosphorus quantum dots with black phosphorus concentrations of 0 ppm, 2 ppm, 5 ppm, 10 ppm and 20 ppm were added respectively, and PBS was used as a blank control. After standing in the incubator for 4 hours, remove the medium containing the drug, carefully add 1mL PBS to each well to wash it two to thr...

Embodiment 3

[0089] Detect the photothermal therapy effect of the black phosphorus quantum dots wrapped in PLGA prepared in Example 1 on tumor cells, and use the CCK-8 method to detect the cell survival rate. The specific steps are as follows: use trypsin (1:250) to grow logarithmically Breast cancer cells (MCF7) were digested from the culture flask to make a cell suspension, and the cell density was adjusted to 5×10 4 cells / mL. Add 1 mL of cell suspension to each well of a 12-well plate, and add 5% volume fraction of CO 2 Culture in an incubator at 37°C. When the cell monolayer covered the bottom of the 24-well plate, the PBS solutions of PLGA-wrapped black phosphorus quantum dots with black phosphorus concentrations of 0 ppm, 2 ppm, 5 ppm, 10 ppm and 20 ppm were added respectively, and PBS was used as a blank control. After standing in the incubator for 4 hours, remove the medium containing the drug, carefully add 1mL PBS to each well to wash it two to three times, absorb the PBS, add ...

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Abstract

The invention provides black phosphorus wrapped with a polymer as well as a preparation method and application thereof. The polymer is a hydrophobic polymer with a water contact angle greater than 90 degrees. The preparation method comprises the following steps of: dispersing to-be-wrapped black phosphorus in an organic solvent solution containing the hydrophobic polymer, so as to obtain a mixed solution; and uniformly mixing the obtained mixed solution with an aqueous solution containing an emulsifying agent, performing sufficient dispersion, and then sufficiently volatilizing the organic solvent to obtain black phosphorus wrapped with the polymer. The black phosphorus is wrapped with the hydrophobic polymer and is completely isolated from oxygen and moisture, so that the stability of black phosphorus in the air is further improved, and the black phosphorus can keep quite good stability in water and even a physiological environment, so that application of black phosphorus in photoelectricity and biomedical photonics is greatly expanded.

Description

technical field [0001] The invention relates to black phosphorus and its preparation method and application, in particular to a polymer-wrapped black phosphorus and its preparation method and application. Background technique [0002] Two-dimensional materials refer to layered materials with a thickness of only one or a few atoms, such as graphene, boron nitride, transition metal chalcogenides, and black phosphorus newly discovered in 2013, which have become a research hotspot. This kind of material has some unique electrical, optical, thermal, mechanical and magnetic properties because electrons are restricted to move in two dimensions, and has broad application prospects in new energy, new materials, electronic devices, biocatalysis, etc. Due to its wide tunable direct bandgap, high carrier mobility and superior anisotropic photoelectric properties, black phosphorus has shown great value in the fields of optoelectronics, energy and biomedical photonics. The advanced manuf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/34A61P35/00
CPCA61K9/5146A61K9/5153A61K41/0052A61K41/0057
Inventor 喻学锋邵俊东谢寒寒王怀雨
Owner SHENZHEN INST OF ADVANCED TECH
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