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A kind of anti-dehydration gecko hydrogel application and preparation method thereof

A hydrogel and anti-dehydration technology, applied in medical science, absorbent pads, bandages, etc., can solve problems such as poor fit and easy dehydration, achieve convenient post-purification treatment, good biological safety, and promote wound moistening healing effect

Active Publication Date: 2019-09-13
NANJING SHINEKING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to make up for the above deficiencies, the purpose of the present invention is to provide an anti-dehydration gecko hydrogel application and its preparation method to solve the problems of low adhesion and easy dehydration in clinical use in the above-mentioned background technology

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] 1) Weigh each component according to the formula, add 0.25 parts by weight of polyvinyl alcohol into 10 parts by weight of water, and dissolve in a water bath at 80°C;

[0056] 2) Add hydrochloric acid to the above solution to adjust the pH of the solution to 2, then add 0.04 parts by weight of polyglutamic acid and 0.03 parts by weight of tannic acid, and stir until dissolved at 25°C;

[0057] 3) Add 0.05 parts by weight of glutaraldehyde with a mass concentration of 2%, stir evenly, remove air bubbles by ultrasonic waves, apply it to a nano-silicon chip mold, and let stand for crosslinking for 10 minutes to obtain a hydrogel;

[0058] 4) The prepared hydrogel is uniformly coated on the non-woven fabric, and then covered with a polyethylene film to obtain a shaped hydrogel application.

Embodiment 2

[0060] 1) Weigh each component according to the formula, add 1.55 parts by weight of polyvinyl alcohol into 23 parts by weight of water, and dissolve in a water bath at 90°C;

[0061] 2) Add hydrochloric acid to the above solution to adjust the pH of the solution to 4, then add 0.27 parts by weight of polyglutamic acid and 0.35 parts by weight of tannic acid, and stir at 45°C until dissolved;

[0062] 3) Add 0.12 parts by weight of glutaraldehyde with a mass concentration of 10%, stir evenly, remove air bubbles by ultrasonic waves, apply it to a nano-silicon wafer mold, and let stand for cross-linking for 60 minutes to obtain a hydrogel;

[0063] 4) The prepared hydrogel is uniformly coated on the non-woven fabric, and then covered with a polyethylene film to obtain a shaped hydrogel application.

Embodiment 3

[0065] 1) Weigh each component according to the formula, add 0.8 parts by weight of polyvinyl alcohol into 17 parts by weight of water, and dissolve in a water bath at 88°C;

[0066] 2) Add hydrochloric acid to the above solution to adjust the pH of the solution to 3, then add 0.04 parts by weight of polyglutamic acid and 0.03 parts by weight of tannic acid, and stir until dissolved at 35°C;

[0067] 3) Add 0.12 parts by weight of glutaraldehyde with a mass concentration of 5%, stir evenly, remove air bubbles by ultrasonic waves, apply it to a nano-silicon wafer mold, and leave it to stand for cross-linking for 20 minutes to obtain a hydrogel;

[0068] 4) The prepared hydrogel is uniformly coated on the non-woven fabric, and then covered with a polyethylene film to obtain a shaped hydrogel application.

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Abstract

The invention belongs to the field of medical high-molecular materials, and discloses a dehydration-prevention gecko hydrogel application and a preparation method thereof. The hydrogel application is prepared from the following raw materials in parts by weight: 0.25-1.55 parts of polyvinyl alcohol, 0.04-0.27 part of polyglutamic acid, 0.03-0.35 part of tannic acid, 0.05-0.12 part of glutaraldehyde having a mass concentration of 2-10 percent, 10-23 parts of water, and the balance of an acidity regulating agent. The gecko hydrogel application can adsorb and closely attach the surface of human skin since the application surface has tissues similar to the nano-sucker structure of gecko feet so as to effectively prevent falling off and effectively prevent hydrogel from being dehydrated. The hydrogel application can be well attached to skin to achieve a self-cleaning effect, and is applicable to wound protection and treatment of physical therapy, burning, scalds and traumatic wounds by cold application.

Description

technical field [0001] The invention belongs to the field of medical polymer materials, in particular to an anti-dehydration gecko hydrogel application and a preparation method thereof. Background technique [0002] Dressings are essential medical supplies. Traditional dressings tend to adhere to skin wound tissues. Changing dressings often destroys new epithelium and granulation tissue, causing bleeding, which is not conducive to wound healing, and causes unbearable pain to patients. Hydrogel is a soft and wet material with a three-dimensional network structure. Its bionic properties such as high water content, non-adhesive wound, and good biocompatibility make it widely used in the field of medical dressings. [0003] However, the current high-end hydrogel dressing mainly has the following two technical barriers: 1. Poor tissue integration, that is, it does not fit closely with the tissue, and cannot actively promote wound repair. The current solution is mainly to apply hy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/42A61L15/26A61L15/24A61L15/58
Inventor 徐虹王瑞迟波李莎冯小海詹伊婧
Owner NANJING SHINEKING BIOTECH CO LTD
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