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Temperature-sensitive type skin wound dressing as well as preparation method and applications thereof

A temperature-sensitive, skin wound technology, applied in the fields of medical science, absorbent pads, bandages, etc., to achieve the effect of promoting wound repair, good repeatability, and easy mass production

Active Publication Date: 2017-01-11
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, in the field of wound repair, there is no skin wound dressing that not only has temperature-sensitive properties, but also uses bioactive glass to promote wound repair.

Method used

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  • Temperature-sensitive type skin wound dressing as well as preparation method and applications thereof
  • Temperature-sensitive type skin wound dressing as well as preparation method and applications thereof
  • Temperature-sensitive type skin wound dressing as well as preparation method and applications thereof

Examples

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preparation example Construction

[0057] In one example, the preparation method of temperature-sensitive skin wound dressing of the present invention comprises:

[0058] Dissolving agar or agarose or a mixture of the two in hot water at 65-95°C to obtain solution A, wherein the mass percentage of the agar or agarose or the mixture of the two is 1-4%;

[0059] Dissolving alginate powder at room temperature to obtain solution B, wherein the mass percentage of alginate is 1% to 4%;

[0060] Mix solution A and solution B at a ratio of 1:1 at 45-60°C, and stir evenly. The resulting mixed solution can maintain a solution state at a temperature above 45°C, and it can be formed after cooling down to around body temperature for about 1-5 minutes. stabilized hydrogels;

[0061] Add bioactive glass in the form of 1-20% by mass to the obtained temperature-sensitive hydrogel solution at 45-60°C, mix evenly, and the obtained mixed solution can maintain a solution state at a temperature above 45°C , Cool down to around bod...

Embodiment 1

[0068] The product prepared in this example is a temperature-sensitive hydrogel containing 1% agarose, 1% sodium alginate and 1% bioactive glass. The specific product preparation process is as follows:

[0069] 1. Dissolve 2% agarose in deionized water at 95°C;

[0070] 2. Dissolve sodium alginate powder with a mass percentage of 2% at room temperature;

[0071] 3. Mix the above two solutions at a ratio of 1:1 at 55°C and stir evenly;

[0072] 4. Change the chemical composition to CaO 24.5%, SiO 2 45%,Na 2 O 24.5%, P 2 o 5 6%, bioactive glass with a particle size of less than 100 microns is added to the temperature-sensitive composite hydrogel solution at a mass percentage of 1%, and mixed evenly.

[0073] The mixed solution obtained from the production process of the above product is temperature-sensitive. It remains in a solution state at a temperature above 45°C, and a stable hydrogel can be formed when the temperature is lowered to around body temperature for 1 min...

Embodiment 2

[0075] The mixed solution was prepared by the same method as in Example 1, except that the mass percentage of bioactive glass was 5%.

[0076] The prepared mixed solution is kept in a solution state at a temperature above 45° C., injected into a mold, and cooled to prepare a hydrogel dressing with a diameter of 6 mm and a thickness of 1 to 2 mm.

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Abstract

The invention relates to a temperature-sensitive type skin wound dressing as well as a preparation method and applications of the temperature-sensitive type skin wound dressing. The temperature-sensitive type skin wound dressing is prepared from the following components in percentage by weight: 1-20 % of biological active glass, and 80-99 % of temperature-sensitive type composite hydrogel, wherein the temperature-sensitive type composite hydrogel is prepared from the following components in percentage by weight: 0.5-2 % of alginate, 0.5-2 % of agar and / or agarose, the balance of water. The temperature-sensitive type skin wound dressing is composed of the temperature-sensitive type composite hydrogel and the biological active glass, is in the solution state at high temperature, can form hydrogel at the temperature close to the body temperature, has a certain bacteria inhibiting effect, and has an acceleration effect for the wound repair.

Description

technical field [0001] The invention belongs to the field of biomedical material technology and wound repair, and relates to a temperature-sensitive skin wound dressing and its preparation method and application. Background technique [0002] Skin trauma is a clinical high-incidence disease, which can be divided into acute trauma or chronic trauma. The human body has a certain self-healing ability for wounds, but when the wound area is too large or the local environment of the wound is disordered (such as insufficient blood supply), the wound cannot be repaired normally, and even cause long-term difficult-to-heal and recurrent wounds. [0003] Bioactive glass is a silicon-based inorganic material that has found many applications in the field of tissue repair. Bioactive glass has been proven to promote vascularization in vivo and in vitro, and has a certain antibacterial effect, and wound repair products based on bioactive glass powder have also appeared clinically. However...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/18
Inventor 常江曾琼玉
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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