Pharmaceutical composition containing sodium ozagrel and preparation method thereof
A technology of sodium ozagrel and its composition, which is applied in the field of pharmaceutical compositions containing sodium ozagrel and its preparation, can solve problems such as local pain, poor stability of sodium ozagrel, and vascular irritation, and achieve process improvement, The effect of improving drug stability
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Embodiment 1
[0032] The pharmaceutical composition containing ozagrel sodium is an injection, which is made into 1000mL, and its raw materials include 38g of ozagrel, 6g of sodium hydroxide, 10g of mannitol, 10g of dextran, 20g of arabinose, and water for injection to make up to 1000mL.
[0033] The preparation method of this injection comprises the following steps:
[0034] Take dextran and add 30% of the total weight of the prepared solution into water for injection, stir in water for injection, boil to dissolve, and cool down to 40-50°C; add the prescribed amount of sodium hydroxide, stir to dissolve, add ozagrel, stir to dissolve; add mannitol Stir to dissolve; use 2mol / L hydrochloric acid solution to adjust the pH value of the liquid to 8.0-9.3; add arabinose, stir to dissolve; add water for injection to the total amount of preparation, add 3‰ of the total weight of the preparation solution of medicinal charcoal, stir and absorb 10 Minutes, after removing charcoal, adjust the volume t...
Embodiment 2
[0036] The pharmaceutical composition containing ozagrel sodium is an injection, which is made into 1000mL, and its raw materials include 40g of ozagrel, 8g of sodium hydroxide, 12g of mannitol, 12g of dextran, 22g of arabinose, and water for injection to make up to 1000mL.
[0037] The preparation method of this injection is with embodiment 1.
Embodiment 3
[0039] The pharmaceutical composition containing ozagrel sodium is an injection, which is made into 1000mL. Its raw materials include 39g of ozagrel, 7g of sodium hydroxide, 11g of mannitol, 11g of dextran, 21g of arabinose, and make up to 1000mL with water for injection.
[0040] The preparation method of this injection is with embodiment 1.
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