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A kind of preparation method of mesoporous bioactive glass/dopamine modified artificial ligament

A bioactive glass, artificial ligament technology, used in drug delivery, tissue regeneration, pharmaceutical formulations, etc., to improve biocompatibility and bioactivity, tight binding, and chemical properties.

Inactive Publication Date: 2019-11-15
SHANGHAI PUDONG HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this property of dopamine has not yet been applied to the modification of artificial ligaments

Method used

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  • A kind of preparation method of mesoporous bioactive glass/dopamine modified artificial ligament
  • A kind of preparation method of mesoporous bioactive glass/dopamine modified artificial ligament
  • A kind of preparation method of mesoporous bioactive glass/dopamine modified artificial ligament

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Effect test

Embodiment 1

[0030] The present invention relates to a kind of preparation method of mesoporous bioactive glass / dopamine modified artificial ligament, comprising the following steps:

[0031] Step 1: soak and wash the PET artificial ligament with 75% alcohol for 4 hours, and then dry it at 37° C. for 12 hours to obtain a pretreated artificial ligament.

[0032] Step 2, modifying the surface of the PET artificial ligament. Dopamine was added to the 10mM Tris-HCl solution with a pH value of 8.5 to form a dopamine solution with a concentration of 1 mg / ml, and the pretreated PET artificial ligament was added to the dopamine solution at a speed of 200 rpm. Stir for 24 hours, wash with deionized water, and dry at 37° C. for 12 hours to obtain a dopamine-modified PET artificial ligament.

[0033] Step 3, MBG modifying the PET artificial ligament. Add 100mg of MBG to 100ml of deionized water, ultrasonically disperse for 15 minutes, then add dopamine-modified PET artificial ligament, stir magneti...

Embodiment 2

[0060] The present invention relates to a kind of preparation method of mesoporous bioactive glass / dopamine modified artificial ligament, comprising the following steps:

[0061] Step 1: soak and wash the PET artificial ligament with 75% alcohol for 4 hours, and then dry it at 37° C. for 12 hours to obtain a pretreated artificial ligament.

[0062] Step 2, modifying the surface of the PET artificial ligament. Dopamine was added to the 10mM Tris-HCl solution with a pH value of 8.5 to form a dopamine solution with a concentration of 2 mg / ml, and the pretreated PET artificial ligament was added to the dopamine solution at a speed of 400 rpm. Stir for 24 hours, wash with deionized water, and dry at 37° C. for 12 hours to obtain a dopamine-modified PET artificial ligament.

[0063] Step 3, MBG modifying the PET artificial ligament. Add 200mg of MBG to 100ml of deionized water, ultrasonically disperse for 30 minutes, then add dopamine-modified PET artificial ligament, stir magneti...

Embodiment 3

[0066] The invention relates to a method for preparing an artificial ligament modified by mesoporous bioactive glass / dopamine. The specific operation method is as follows:

[0067] The PET artificial ligament was soaked and cleaned with 75% alcohol for 4 hours, and then dried at 37° C. for 12 hours to obtain a pretreated artificial ligament. Add 100 mg of MBG to 100 ml of 10 mM Tris-HCl solution with a pH value of 8.5. After ultrasonic treatment for 15 minutes, add the pretreated artificial ligament and 100 mg of dopamine at the same time, stir magnetically at a speed of 200 rpm for 12 hours, and use After washing with ionized water and drying at 37°C for 12 hours, a mesoporous bioactive glass / dopamine-modified PET artificial ligament was obtained.

[0068] The preparation method of the MBG is a sol-gel method. After the dry gel is ball milled and crushed, it passes through a 400-mesh sieve to obtain MBG particles with a particle size of less than 37 microns.

[0069] Compare...

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Abstract

The invention relates to the field of biological materials, in particular to a preparation method of an artificial mesoporous bioactivity glass / dopamine modified artificial ligament. The preparation method has the advantages that the surface of a PET artificial ligament is modified through auto-agglutination of dopamine, and MBG is evenly bond to the surface of the ligament to achieve a coating effect, so that biocompatibility and bioactivity of the artificial ligament are enhanced; the PET artificial ligament is coated with the MBG with high bone induction capability, so that biocompatibility and bioactivity of the artificial ligament are improved, and connection between the artificial ligament and a host bone is tighter; coatings are uniform and firm, the process is simple, the preparation method is convenient and rapid to operate, and pollution to environment is small.

Description

technical field [0001] The invention relates to the field of biomaterials, and relates to a method for preparing an artificial ligament, in particular to a method for preparing an artificial ligament modified by mesoporous bioactive glass / dopamine. Background technique [0002] Anterior cruciate ligament injury (ACL) is one of the common sports injuries in clinical practice. Aiming at the repair and reconstruction of ACL, several studies have shown that polyethylene terephthalate (PET) artificial ligament has short-term and short-term curative effects and The safety is relatively satisfactory, but there are still problems such as poor tendon-bone healing and complications. This is mainly due to the poor biocompatibility of PET artificial ligaments and the presence of fibrous scars between them and the host bone that hinder healing. Therefore, how to improve the compatibility and bioactivity of PET artificial ligaments has become the focus of researchers in recent years. At...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/32A61L27/18
CPCA61L27/18A61L27/32A61L2400/18A61L2430/10C08L67/02
Inventor 朱钰方丁惠锋裴鹏俞斌
Owner SHANGHAI PUDONG HOSPITAL
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