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Preparing method and application of fluorescence-imaging copper-and-nitrogen-doped carbon quantum dots with dual-light-treating effect

A carbon quantum dot, fluorescence imaging technology, applied in photodynamic therapy, preparations for in vivo experiments, medical preparations containing active ingredients, etc. Effects of photothermal stability, increased reactive oxygen species level, and simple synthesis method

Active Publication Date: 2017-02-01
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Copper and nitrogen doped carbon quantum dots are rarely reported, and there is no research on copper and nitrogen doped carbon quantum dots for photothermal and photodynamic therapy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Weigh 3.72 g of EDTA disodium salt and 1.70 g of copper chloride dihydrate, add 200 mL of secondary water and stir for 6-8 hours.

[0024] 2. Filter the blue solution after stirring and reacting to obtain a clear blue solution.

[0025] 3. Add the solution to a 25 mL hydrothermal reactor for reaction, heat up to 150°C for 3 hours, continue to heat up to 200°C for 3 hours, and naturally cool to room temperature to obtain a green solution.

[0026] 4. Transfer the green solution to a beaker and dialyze the filtrate for 48 hours with a molecular weight cut off of 500-1000.

[0027] 5. After dialysis, the liquid is freeze-dried, and the green solid obtained is copper and nitrogen-doped carbon quantum dots, which should be kept away from light.

[0028] The prepared carbon quantum dots were redissolved in water, and it was still a green solution, which could emit blue fluorescence under a 365 nm ultraviolet lamp, and could realize photothermal heating and generate active...

Embodiment 2

[0030] 1. Weigh 3.72 g of EDTA disodium salt and 1.70 g of copper chloride dihydrate, add 150 mL of secondary water and stir for 6-8 hours.

[0031] 2. Filter the blue solution after stirring and reacting to obtain a clear blue solution.

[0032] 3. Add the solution to a 25 mL hydrothermal reactor for reaction, heat up to 150°C for 3 hours, continue to heat up to 200°C for 3 hours, and naturally cool to room temperature to obtain a green solution.

[0033] 4. Transfer the green solution to a beaker and dialyze the filtrate for 48 hours with a molecular weight cut off of 500-1000.

[0034] 5. After dialysis, the liquid is freeze-dried, and the green solid obtained is copper and nitrogen-doped carbon quantum dots, which should be kept away from light.

[0035] The prepared carbon quantum dots were redissolved in water, and it was still a green solution, which could emit blue fluorescence under a 365 nm ultraviolet lamp, and could realize photothermal heating and generate active...

Embodiment 3

[0037] 1. Weigh 3.72 g of ethylenediaminetetraacetic acid disodium salt and 1.70 g of copper chloride dihydrate, add 250 mL of secondary water and stir for 6-8 hours.

[0038] 2. Filter the blue solution after stirring and reacting to obtain a clear blue solution.

[0039] 3. Add the solution to a 25 mL hydrothermal reactor for reaction, heat up to 150°C for 3 hours, continue to heat up to 200°C for 3 hours, and naturally cool to room temperature to obtain a green solution.

[0040] 4. Transfer the green solution to a beaker and dialyze the filtrate for 48 hours with a molecular weight cut off of 500-1000.

[0041] 5. After dialysis, the liquid is freeze-dried, and the green solid obtained is copper and nitrogen-doped carbon quantum dots, which should be kept away from light.

[0042] The prepared carbon quantum dots were redissolved in water, and it was still a green solution, which could emit blue fluorescence under a 365 nm ultraviolet lamp, and could realize photothermal ...

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Abstract

The invention discloses a preparing method and application of fluorescence-imaging copper-and-nitrogen-doped carbon quantum dots with the dual-light-treating effect. The carbon quantum dots prepared with the method can emit blue fluorescence, and meanwhile the photo-thermal effect, the photodynamic treating effect and the fluorescence imaging effect can be achieved. According to the preparing method, ethylenediamine tetraacetic acid disodium salt and copper chloride dihydrate serve as raw materials, and the copper-and-nitrogen-doped carbon quantum dots are prepared. According to the preparing method and application of the fluorescence-imaging copper-and-nitrogen-doped carbon quantum dots with the dual-light-treating effect, the raw materials are low in cost and easy to obtain and prepare, and an obtained product has the good biocompatibility and the good water solubility, can emit the blue fluorescence, has the absorbing effect and the good photothermal conversion efficiency in infrared and near infrared regions, has the photosensitization effect, and can generate reactive oxygen for photodynamic therapy under illuminating of near-infrared light. The copper-and-nitrogen-doped carbon quantum dots prepared with the method have broad application prospects in the photothermal therapy aspect, the photodynamic therapy aspect, the bioimaging aspect and the like.

Description

technical field [0001] The invention relates to photothermal, photodynamic therapy and fluorescence imaging materials, in particular to a preparation method and application of copper and nitrogen doped carbon quantum dots with dual phototherapy effects and fluorescence imaging. Background technique [0002] Carbon quantum dots were first discovered by scientists at Clemson University in the United States in 2004. Compared with traditional semiconductor quantum dots, carbon quantum dots have the advantages of more stable luminescence, easier functionalization, and better water solubility. Carbon quantum dots retain the advantages of low toxicity and good biocompatibility of carbon materials, making them have great application prospects in cell imaging, biosensing, drug carriers, and photocatalysis. Some carbon quantum dots with novel functions can be obtained by doping carbon quantum dots with elements such as nitrogen and sulfur. For example, in 2015, Wang Pengfei of the In...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65A61K49/00A61K41/00B82Y40/00
CPCA61K41/0052A61K41/0057A61K49/0019A61K49/0067B82Y40/00C09K11/0883C09K11/65
Inventor 沈星灿郭晓路蒋邦平余云祥邓思敏
Owner GUANGXI NORMAL UNIV
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