Nano composite hydrogel for bleeding control and preparation method thereof

A technology of nanocomposite and hydrogel, which is applied in the field of preparation of nanocomposite hydrogel to achieve the effects of reducing degradation rate, good expansibility and stability, and excellent mechanical properties

Inactive Publication Date: 2020-12-25
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It was found that the addition of cellulose nanofibers can significantly improve the mechanical strength of starch, however, the addition of nanofibers also has certain limitations due to the agglomeration of nanofibers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A method for preparing a nanocomposite hydrogel for bleeding control, the specific operation steps are as follows:

[0027] S1. Dissolve 1g of cornstarch in 30mL of double distilled water at 92°C, mix for 1h to obtain a uniform solution, add 0.03g of potassium persulfate at 50°C and mix for 20min to obtain solution A; 2g of cellulose nanofibers (average diameter 32nm ) was dispersed in 3mL of water, 3.65g of acrylic acid and 0.0365g of N-methylenebisacrylamide were dissolved in 7mL of water, and all the cellulose nanofiber dispersion was mixed with all of the acrylic acid and N-methylenebisacrylamide Mix the aqueous solution evenly to obtain solution B; add all of solution B to all of solution A and stir for 2 hours, then add 2 mL of 10 wt% sodium hydroxide solution, and react at 92°C for 1 hour; then place it in ethanol for 2 hours, and dissolve it Cut into small pieces, place them in double distilled water and ethanol for 24 hours respectively, and finally dry at 60°C...

Embodiment 2

[0031] A method for preparing a nanocomposite hydrogel for bleeding control, the specific operation steps are as follows:

[0032] S1. Dissolve 1g of cornstarch in 30mL of double distilled water at 80°C, mix for 1h to obtain a uniform solution, add 0.03g of potassium persulfate at 60°C and mix for 10min to obtain solution A; 2g of cellulose nanofibers (average diameter 32nm ) was dispersed in 3mL of water, 3.65g of acrylic acid and 0.0365g of N-methylenebisacrylamide were dissolved in 7mL of water, and all the cellulose nanofiber dispersion was mixed with all of the acrylic acid and N-methylenebisacrylamide Mix the aqueous solution evenly to obtain solution B; add all of solution B to all of solution A and stir for 3 hours, add 2mL, 10wt% sodium hydroxide solution, and react at 80°C for 2 hours; then place it in ethanol for 2 hours, and dissolve it Cut into small pieces, place them in double distilled water and ethanol for 24 hours respectively, and finally dry at 70°C to obta...

Embodiment 3

[0036] A method for preparing a nanocomposite hydrogel for bleeding control, the specific operation steps are as follows:

[0037] S1. Dissolve 20g of cornstarch in 600mL of double distilled water at 98°C, mix for 1h to obtain a uniform solution, add 0.6g of potassium persulfate at 70°C and mix for 30min to obtain solution A; 40g of cellulose nanofibers (average diameter 40nm ) was dispersed in 60mL of water, 73g of acrylic acid and 0.073g of N-methylenebisacrylamide were dissolved in 140mL of water, and all of the cellulose nanofiber dispersion was mixed with all of the aqueous solution containing acrylic acid and N-methylenebisacrylamide Mix evenly to obtain solution B; add all solution B to all solution A and stir for 5 hours, add 40mL, 10wt% sodium hydroxide solution, and react at 98°C for 2 hours; then place it in ethanol for 3 hours, cut it into small pieces, then placed in double-distilled water and ethanol for 28 hours each, and finally dried at 80°C to obtain a starch...

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Abstract

The invention provides nano composite hydrogel for bleeding control and a preparation method thereof. The preparation method comprises the following steps that an initiator is decomposed to generate free radicals to initiate a free radical polymerization reaction to graft acrylic acid to the surface of starch, then the starch and cellulose nanofibers are cross-linked with each other by a cross-linking agent to form a reticular structure, and starch / cellulose nanofiber hydrogel is wrapped with K-carrageenan to obtain the nano composite hydrogel for bleeding control. According to the method, themechanical property of starch-based hydrogel can be improved, meanwhile, the excellent performance of the hydrogel can be kept, and the prepared nano composite hydrogel is low in degradation rate, high in mechanical strength and good in expansion performance and hemostatic performance.

Description

technical field [0001] The invention belongs to the technical field of colloid gel, and in particular relates to a preparation method of a K-carrageenan nanocomposite hydrogel. Background technique [0002] Hydrogels, as highly porous materials that are hydrophilic, biocompatible, and biodegradable, are suitable for biomedical applications, including drug delivery, tissue engineering, wound dressing, and bleeding control. Hydrophilic functional groups including hydroxyl (–OH) and carboxyl (–COOH) groups absorb a large amount of water in the three-dimensional network and swell to fill the lesion cavity. In addition, the swollen network can provide high water content at the wound site, thereby accelerating the cellular function and angiogenic process to contract the wound. Meanwhile, the three-dimensional structure of the hydrogel can provide a suitable platform to embed antibiotics, growth factors, supplementary molecules, and macromolecules to accelerate the wound healing p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00C08F251/02C08F251/00C08F220/06C08F222/38C08J7/00C08J3/075C08L51/02
CPCA61L24/0031A61L24/0042A61L24/08A61L2400/04A61L2400/12C08F251/00C08F251/02C08J3/075C08J7/00C08J2351/02C08J2405/00C08J2451/00C08F220/06C08F222/385C08L3/02C08L1/02C08L5/00
Inventor 李坚斌詹阿慧张明均李凯王雪峰
Owner GUANGXI UNIV
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