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Biological bone cement

A bone cement, bio-based technology, applied in tissue regeneration, medical science, prosthesis, etc.

Inactive Publication Date: 2017-02-15
爱本斯南京医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the non-degradability of PMMA itself is destined to have considerable limitations in its own application.

Method used

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  • Biological bone cement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Effect of α-Calcium Sulfate Hemihydrate Coated with Different Materials on the Performance of Bone Cement

[0037] (1) Alanine-coated calcium sulfate hemihydrate (10.6%), animal collagen-coated calcium sulfate hemihydrate (10.6%), glutathione-coated calcium sulfate hemihydrate (10.6%) , Polyethylene glycol (PEG400)-coated α-calcium sulfate hemihydrate (10.6%), glycerol-coated α-calcium sulfate hemihydrate (10.6%) and PMMA (70.7%), zirconium oxide (16.7%), BPO (2%) is mixed uniformly to obtain bone cement powder.

[0038] (2) Add N,N-dimethyl-p-toluidine (0.75%) and hydroquinone (0.75%) to the pre-mixed MMA (98.5%), dissolve and mix by stirring to obtain bone cement liquid Agent.

[0039] (3) Using a bone cement mixing and mixing system, add the powder first according to the powder-to-liquid mass ratio of 2:1, add the corresponding liquid ingredients, and mix well, the bone cement has 5-8 minutes injection time, and the bone will be obtained after solidification. ...

Embodiment 2

[0044] Example 2: The effect of different initiators in the liquid on the performance of bone cement

[0045] (1) Glutathione-coated α-calcium sulfate hemihydrate (10.6%) and acrylic acid and methyl methacrylate copolymer (70.7%), zirconia (16.7%), and BPO (2%) are mixed uniformly, Obtain bone cement powder.

[0046] (2) Add camphorquinone (1.5%) or N,N-dimethyl-p-toluidine (1.5%) to the premixed MMA (98.5%), dissolve and mix by stirring to obtain a bone cement liquid.

[0047] (3) Using a bone cement mixing and mixing system, add the powder first according to the powder-to-liquid mass ratio of 2:1. After adding the corresponding liquid ingredients and mixing well, the bone cement has 5-8 minutes injection time, and the bone will be obtained after solidification. cement.

[0048] According to the bone cement industry standard, the maximum temperature and curing time of bone cement were measured, the bone cement was injected into a suitable mold and cured for 1 hour, compressive sampl...

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PUM

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Abstract

The invention discloses biological bone cement. Calcium sulfate hemihydrate is coated by an absorbable hydrophilic biological material to form micro-spheres, and the micro-spheres are added into acrylic bone cement according to a certain proportion; and in vivo, the calcium sulfate hemihydrate with a surface coated by the absorbable hydrophilic biological material between a tissue and the bone cement is gradually degraded, then a micro-porous structure is formed on the surface of the bone cement, and the biological tissues around continuously fill the micro-pores, so that the contact area between the bone cement and the human body tissue is greatly increased, the fixation strength of the bone cement is enhanced, the incidence of 'bone cement disease' is further reduced, and clinical advantages are obvious.

Description

Technical field [0001] The invention relates to a biological type bone cement. Calcium sulfate hemihydrate is wrapped with absorbable hydrophilic biomaterials to form microspheres, and the microspheres are added to acrylic bone cement in a certain proportion to enhance the biocompatibility of the bone cement. Used in the field of orthopedic materials. Background technique [0002] PMMA bone cement (polymethyl methacrylate) is currently the most clinically used bone cement, which is composed of powder and liquid. The main component of powder is PMMA, and the main component of liquid is MMA (methyl methacrylate) monomer. The current formulations of bone cement on the market are: German one is composed of powder and liquid. Powders include: methyl acrylate-methyl methacrylate polymer, zirconium dioxide, benzoyl peroxide and a small amount of chlorophyll, used for internal fixation of implanted prostheses in joint replacement surgery; liquids include: methyl methacrylate , N, N-Di...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/02A61L27/50A61L27/54A61L27/56A61L27/58
CPCA61L27/16A61L27/025A61L27/50A61L27/54A61L27/56A61L27/58A61L2430/02C08L33/10
Inventor 李斌张文芳
Owner 爱本斯南京医疗器械有限公司
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