Chitosan hemostatic wound-healing material and preparation method thereof

A technology of chitosan and chitosan acetic acid, which is applied in the directions of medical formula, application, and medical science, can solve the problems of limited hemostasis of hemostatic materials, limited hemostatic effect, and less promotion of healing, so as to promote wound healing, maintain strength, The effect of preventing secondary bleeding

Active Publication Date: 2017-02-22
杭州浙海企业管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hemostatic effect of pure chitosan material is limited, and for wounds with heavy bleeding, its adhesion is poor and hemostasis is slow
In addition, only relying on chitosan itself to achieve auxiliary functions such as anti-inflammation, antibacterial, and tissue repair other than hemostasis has very limited effects.
Most of the existing hemostatic materials are limited to simple hemostasis, and there are relatively few studies on promoting healing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0057] The preparation method of above-mentioned chitosan hemostatic healing wound material, comprises the steps:

[0058] Step a: Preparation of chitosan rapid hemostatic layer:

[0059] Step a1, preparation of chitosan acetic acid solution: add chitosan to 1-2v / v% acetic acid solution, stir evenly, and prepare a chitosan acetic acid solution with a concentration of 1-2w / v%, and set aside; chitosan The degree of deacetylation of sugar is 75-95%, and the molecular weight is 100,000-1 million;

[0060] Step a2, preparation of calcium chloride solution: adding calcium chloride to deionized water, stirring evenly, preparing a calcium chloride solution with a concentration of 1-3w / v% for later use;

[0061] Step a3, preparation of starch nanosphere solution: adding starch nanospheres to deionized water, stirring evenly, and preparing a starch nanosphere solution with a concentration of 5-6w / v% for later use; starch nanospheres include potato starch Nanospheres, cornstarch nanosp...

Embodiment 1

[0073] A preparation method of chitosan hemostatic healing material, comprising the steps of:

[0074] Step a: Preparation of chitosan rapid hemostatic layer:

[0075] Step a1, preparation of chitosan acetic acid solution: add chitosan to 1.5v / v% acetic acid solution, stir evenly, and prepare a chitosan acetic acid solution with a concentration of 1.5w / v%, for subsequent use; chitosan The degree of deacetylation is 80%, the molecular weight is 500,000;

[0076] Step a2, preparation of calcium chloride solution: adding calcium chloride to deionized water, stirring evenly, and preparing a calcium chloride solution with a concentration of 2w / v% for later use;

[0077] Step a3, preparation of the starch nanosphere solution: adding the starch nanosphere into deionized water, stirring evenly, and preparing a starch nanosphere solution with a concentration of 5.5w / v% for later use;

[0078] Step a4, preparation of nano-silver solution: adding nano-silver into deionized water, stirr...

Embodiment 2

[0088] A preparation method of chitosan hemostatic healing material, comprising the steps of:

[0089] Step a: Preparation of chitosan rapid hemostatic layer:

[0090] Step a1, preparation of chitosan acetic acid solution: add chitosan to 1v / v% acetic acid solution, stir evenly, and prepare a chitosan acetic acid solution with a concentration of 1w / v%, for subsequent use; deacetylation of chitosan 75% density, 100,000 molecular weight;

[0091] Step a2, preparation of calcium chloride solution: add calcium chloride to deionized water, stir evenly, and prepare a calcium chloride solution with a concentration of 1w / v% for later use;

[0092] Step a3, preparation of the starch nanosphere solution: adding the starch nanosphere into deionized water, stirring evenly, and preparing a starch nanosphere solution with a concentration of 5w / v% for later use;

[0093] Step a4, preparation of nano-silver solution: adding nano-silver to deionized water, stirring evenly, and preparing a na...

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PUM

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Abstract

The invention discloses a chitosan hemostatic wound-healing material. The chitosan hemostatic wound-healing material comprises at least two layers of structures, wherein the lower layer is a chitosan rapid hemostatic layer; the upper layer is a chitosan slow release layer; the chitosan rapid hemostatic layer is obtained by evenly mixing a chitosan-acetic acid solution, carrying out cross-linking reaction for 3-6 hours, then adding a starch nano-microsphere solution and a nano-silver solution, mixing evenly, pouring in a mold, pre-freezing, and freezing and drying under vacuum; and the chitosan slow release layer is obtained by evenly mixing a chitosan-acetic acid solution, a calcium chloride solution, a thrombin solution and a nano-silver solution, carrying out cross-linking reaction for 3-6 hours, pouring in a mold, pre-freezing, and freezing and drying under vacuum. The chitosan hemostatic wound-healing material simultaneously has effects of rapidly stopping bleeding and promoting wound healing.

Description

technical field [0001] The invention relates to the technical field of hemostatic materials, in particular to a chitosan hemostatic and healing material and a preparation method thereof. Background technique [0002] Excessive blood loss is the main cause of death from war injuries and one of the leading causes of death during accidents and surgical procedures. An ideal hemostatic material can effectively reduce casualties. Chitosan is a new type of hemostatic material developed by researchers. It is gradually used clinically because of its good biocompatibility to the human body, biodegradability, and ability to promote wound healing. However, the hemostatic effect of pure chitosan material is limited, and for wounds with a large amount of bleeding, its adhesion is poor and hemostasis is slow. In addition, only relying on chitosan itself to achieve auxiliary functions other than hemostasis, such as anti-inflammation, antibacterial, and promotion of tissue repair, has very...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/02A61L24/00
CPCA61L24/001A61L24/0015A61L24/02A61L24/08A61L2300/104A61L2300/232A61L2300/404A61L2300/412A61L2300/418A61L2300/602A61L2400/04C08L5/08C08L3/02
Inventor 胡巧玲孙永富施建基
Owner 杭州浙海企业管理有限公司
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