Hollow sea urchin type magneto-optic nano-composite medicine carrying system and preparing method thereof

A nano-composite and sea urchin technology, which is applied in the direction of pharmaceutical formulations, microcapsules, medical preparations containing active ingredients, etc., can solve the problems of small specific surface area of ​​magnetic targeting drug carriers and unfavorable loading of drugs, and achieve novel preparation process and operation method Simple, good for mass production

Inactive Publication Date: 2017-03-15
JILIN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the above problems and at the same time solve the problem that the small specific surface area of ​​the existing magnetic targeting drug carrier is not conducive to drug loading, the present invention provides a hollow sea urchin type magneto-optical nanocomposite drug carrier and its preparation method

Method used

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  • Hollow sea urchin type magneto-optic nano-composite medicine carrying system and preparing method thereof
  • Hollow sea urchin type magneto-optic nano-composite medicine carrying system and preparing method thereof
  • Hollow sea urchin type magneto-optic nano-composite medicine carrying system and preparing method thereof

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Embodiment 1

[0021] Step A, dissolving ferric salt in ethylene glycol to form solution I; adding sodium acetate to solution I to form solution II and stirring and mixing; adding sodium lauryl sulfate, stirring and mixing for 1 to 2 hours to form a precursor solution; Transfer the precursor solution to the reaction kettle and react at 200°C for 5-14 hours; collect Fe after washing and drying 3 o 4 Hollow sphere; Wherein sodium lauryl sulfate: ferric salt: the mol ratio of sodium acetate is (3~9):30:100;

[0022] Step B, dissolve NaOH in 65mL ethanol to obtain 0.05-0.06M NaOH ethanol solution; Zn(Ac) 2 2H 2 O and Fe 3 o 4 Disperse hollow spheres in 65mL of ethanol, ultrasonically disperse at 60°C while mechanically stirring for 1.5h to obtain mixed solution I, add 0.375-1.5g polyvinylpyrrolidone to mixed solution I, and continue ultrasonic stirring at 60°C for 1h to obtain mixed solution II; NaOH ethanol solution was added dropwise to the mixed solution II. After the dropwise addition, ...

Embodiment 2

[0025] Step A, 1.62g FeCl 3 ·6H 2 O was added to 60mL of ethylene glycol solution, and mechanically stirred for 30 minutes to completely dissolve to form a yellow solution ①, and then 2.7g of NaAc·3H 2 O was added to the above solution ①, and the mechanical stirring was continued for 1 hour to form a mixed solution ②. Add 0.1839 g of sodium lauryl sulfate to the above mixed solution ②, and continue mechanical stirring for 1 hour to obtain the final precursor solution. Then the precursor solution was loaded into a 100 mL stainless steel reactor lined with polytetrafluoroethylene, and reacted at 200 °C for 10 h. After the solvothermal reaction is finished, cool to room temperature, take out the product, wash and dry, and obtain Fe 3 o 4 hollow ball.

[0026] Step B. Dissolve 0.15g NaOH in 65mL ethanol, stir magnetically for a certain period of time until dissolved, and obtain a NaOH solution. 0.27g Zn(Ac) 2 2H 2 O and 50mg Fe 3 o 4 Disperse the hollow spheres in 160mL ...

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Abstract

The invention discloses a hollow sea urchin type magneto-optic nano-composite medicine carrying system and a preparing method thereof, and belongs to the technical field of nano-composite materials. By adding lauryl sodium sulfate in a solvothermal method, Fe3O4 hollow ball with good water solubility can be prepared and obtained within a short period of time. The hollow sea urchin type nano-composite medicine carrying system wotj an Fe3O4 hollow ball @ ZnO nano-bar structure can be prepared by organically combining with ZnO nano-bars by means of self-assembly. The system has both optical and magnetic properties, and has a large specific surface area, which facilitates medicine loading. Moreover, the preparing method has simple steps, gentle conditions and low cost, and is adapted for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of nanocomposite materials, and relates to a method for preparing a hollow sea urchin-shaped magneto-optical nanocomposite drug-loading system. Background technique [0002] In recent years, the development of nano-drug carriers with good biocompatibility, stable structure, and high drug delivery and targeting efficiency has become a research hotspot in the field of biomedicine. Multifunctional inorganic nanomaterials not only have controllable morphology and large specific surface area, but also are easy to modify the surface and can be endowed with unique electrical, magnetic, optical, and wave-absorbing properties, which are not only conducive to improving the therapeutic effect of anti-tumor drugs, but also It can also reduce the toxic and side effects of anti-tumor drugs on normal human cells, so multifunctional inorganic nanomaterials have obvious advantages in cancer treatment and drug delivery. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/08A61K9/50A61K47/02A61K41/00
CPCC01G49/08A61K9/501A61K9/5078A61K41/00C01P2004/03C01P2004/04C01P2004/34C01P2006/12C01P2006/42C01P2006/60
Inventor 杨景海杨丽丽潘梦蕖魏茂彬范厚刚
Owner JILIN NORMAL UNIV
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