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Preparing method of silver-containing anti-bacterial dressing

A technology of silver nitrate and ascorbic acid, which is applied in the field of medicine and health, can solve the problems of secondary trauma, poor water absorption, and easy adhesion of wounds, and achieve the effects of avoiding secondary trauma, simple preparation method, and fast wound healing

Inactive Publication Date: 2017-03-22
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cotton medical dressings have certain water absorption, soft texture, and cheap price, but their water absorption is poor, and they cannot absorb a large amount of wound exudate. Moreover, the biggest problem with pure cotton dressings is that they are prone to adhesion after wound care , the removal of adhesive gauze often causes secondary trauma to the wound, and pure cotton dressings have no antibacterial properties, which is not conducive to wound healing

Method used

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  • Preparing method of silver-containing anti-bacterial dressing
  • Preparing method of silver-containing anti-bacterial dressing
  • Preparing method of silver-containing anti-bacterial dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A. Under the condition of 10°C, add the absorbent cotton gauze into the sodium hydroxide solution with a mass concentration of 20% to carry out the swelling reaction for 30 minutes, filter and dry after the reaction, and obtain the product A;

[0029] B. At 70°C, add product A to chloroacetic acid aqueous solution with a mass concentration of 15% to react for 15 minutes. Dry to obtain carboxymethyl cellulose cotton with carboxymethyl substitution degree of 0.47, the mass ratio of its absorbent cotton gauze to sodium hydroxide solution is 1:25, and the mass ratio of chloroacetic acid aqueous solution to product A is 5:1;

[0030] C, under the condition of 20 DEG C, polyvinylpyrrolidone is dissolved in ethanol to obtain a polyvinylpyrrolidone ethanol solution with a mass concentration of polyvinylpyrrolidone of 0.01%, and then add silver nitrate to obtain silver nitrate with a mass concentration of silver nitrate of 0.005% Ethanol solution, where ethanol is absolute ethan...

Embodiment 2

[0033] A. Under the condition of 15° C., the absorbent cotton gauze was added to a sodium hydroxide solution with a mass concentration of 22% for a swelling reaction for 35 minutes, and after the reaction, it was filtered and dried to obtain product A;

[0034] B. At 75°C, add product A to chloroacetic acid aqueous solution with a mass concentration of 20% and react for 18 minutes. Dry to obtain carboxymethyl cellulose cotton with carboxymethyl substitution degree of 0.45, the mass ratio of its absorbent cotton gauze to sodium hydroxide solution is 1:28, and the mass ratio of chloroacetic acid aqueous solution to product A is 10:3;

[0035] C, under the condition of 25 DEG C, polyvinylpyrrolidone is dissolved in ethanol, and the polyvinylpyrrolidone mass concentration obtained is 0.03% polyvinylpyrrolidone ethanol solution, and then silver nitrate is added to obtain silver nitrate ethanol with a silver nitrate mass concentration of 0.008% Solution, where the ethanol is absolut...

Embodiment 3

[0038] A. Under the condition of 20° C., the absorbent cotton gauze was added to a sodium hydroxide solution with a mass concentration of 24% to carry out a swelling reaction for 40 minutes, and filtered and dried after the reaction to obtain product A;

[0039] B. At 80°C, add product A to chloroacetic acid aqueous solution with a mass concentration of 25% and react for 20 minutes. After the reaction, use acetic acid with a mass concentration of 30% to adjust to neutrality, wash with ethanol and dry at 80°C , to obtain carboxymethyl cellulose cotton with carboxymethyl substitution degree of 0.5, the mass ratio of its absorbent cotton gauze to sodium hydroxide solution is 1:30, and the mass ratio of chloroacetic acid aqueous solution to product A is 2:1;

[0040] C, under the condition of 30 DEG C, dissolving polyvinylpyrrolidone in ethanol to obtain polyvinylpyrrolidone mass concentration is 0.05% polyvinylpyrrolidone ethanol solution, then add silver nitrate to obtain silver ...

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Abstract

The invention belongs to the technical field of medicine and health and particularly relates to a preparing method of a silver-containing anti-bacterial dressing. According to the method, degreased cotton gauze serves as a base dressing to be improved, at first, the degreased cotton gauze is subjected to carboxymethylation modification and endowed with a high hygroscopic property, then by means of the in-situ reduction effect, nanometer silver particles directly cover the modified degreased cotton gauze, the nanometer silver particles are combined with the degreased cotton gauze closely and do not fall off, and the obtained silver-containing anti-bacterial dressing has a high anti-bacterial property and a high hygroscopic property, does not stick to wounds and avoids secondary trauma and infection of the wounds, so that healing of the wounds is accelerated.

Description

technical field [0001] The invention belongs to the technical field of medicine and hygiene, and in particular relates to a preparation method of a silver-containing antibacterial dressing. Background technique [0002] As an important part of the human immune system, the skin plays a role in preventing harmful substances from entering the subcutaneous tissue. Trauma often inevitably causes skin damage, and pathogens such as bacteria invaded from this, the wound is prone to inflammation, suppuration, infection, resulting in scars and tissue lesions, and the infection caused by open wounds before antibiotics are used in large quantities. Many patients died. Today, repeated inflammation causes many healing problems, such as chronic wounds that are difficult to heal. Therefore, reducing the exposure of subcutaneous tissue, creating a moist healing environment to accelerate the healing of damaged skin, and inhibiting the proliferation of microbial pathogens at the wound surfac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/44A61L15/28
CPCA61L15/18A61L15/28A61L15/44A61L2300/104A61L2300/404C08L1/286
Inventor 蓝广芊代方银陆飞
Owner SOUTHWEST UNIVERSITY
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