Synthetic method for alkyl group phosphorous acid diester compounds or alkyl group phosphinic acid ester compounds

Abstract

The invention discloses a synthetic method for alkyl group phosphorous acid diester compounds or alkyl group phosphinic acid ester compounds. According to the synthetic method, alcohols which are cheap, easy to get, wide in source, stable and low in toxicity serve as alkylating reagents, iodine salt which is cheap and easy to get serves as catalysts, no solvent is needed, and the alkyl group phosphorous acid diester compounds can be selectively directly obtained after a reaction. The reaction method is simple, the condition is mild, no organic solvent is needed and operation is simple. According to the method, the requirements for reaction conditions are low, various types of alcohols such as a benzyl group type, an allyl type and a fat type can be utilized as the alkylate reagents to implement the synthesis of different types of substituted alkyl group phosphorous acid diester, and the method can be further expanded to the synthesis of the alkyl group phosphinic acid ester compounds through the reaction between the substituted phosphonous acid diester and the alcohols.

Description

technical field [0001] The invention belongs to the field of chemical synthesis, and in particular relates to a method for synthesizing an alkyl phosphinate diester compound or an alkyl phosphinate compound under the catalysis of an iodine salt. Background technique [0002] Alkyl phosphinate and alkyl phosphinate structures and their derivatives are abundant in natural products and pharmacologically active compounds. They can also be used as intermediate products and can be further converted into alkylphosphinic acid and alkylphosphinic acid compounds, as well as alkenes and other biologically active molecules with good anticancer and antioxidative abilities. Therefore, the synthesis of alkyl phosphinates and alkyl phosphinate compounds has attracted the attention of more and more organic chemists. [0003] Taking the synthesis of alkyl phosphonites as an example, the traditional method is generally synthesized by the Arbuzov reaction of halogenated hydrocarbons and phosph...

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Problems solved by technology

[0003] Taking the synthesis of alkyl phosphonite as an example, the traditional method is generally synthesized by Albuzov reaction of halogenated hydrocarbon and phosphite at high temperature. Halogenated hydrocarbons are used as alkylating reagents, and the reaction will produce small molecule halogenated hydrocarbons with high activity and low boiling point as by-products, causing pollution

At present, there is also a method for preparing alkyl phosphonite compounds by using alcohol as an alkylating agent to directly react with phosphite, but it is necessary to use an excessive amount of activator (such as zinc iodide) to promote the reaction, and there are also many reaction by-products. , purification difficulties and other issues

In summary, the known synthetic methods of alkyl phosphonites still have many shortcomings, which hinder their further application in synthesis and industry.

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