Preparation method for lignin drug sustained release microspheres

A slow-release microsphere and lignin technology, which is applied in drug delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of uneven particle size, poor controllability of shape, and wide distribution of carriers. Achieve good industrial application prospects, simple and effective preparation method, uniform particle size effect

Inactive Publication Date: 2017-04-19
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a preparation method of lignin drug sustained-release microspheres, so as to overcome the complicated preparation process of the existing drug carrier, and the prepared carrier has uneven particle size, wide distribution, poor controllability of shape, slow Disadvantages such as poor release effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A preparation method of lignin drug slow-release microspheres, the operation steps are as follows:

[0030] (1) Preparation of the internal phase solution: the drug orlistat was dissolved in the organic solvent methyl formate to prepare an organic solution with a mass concentration of 1%, as the internal phase solution;

[0031] (2) Preparation of mesophase solution: Alkali lignin is dissolved in water to prepare a lignin aqueous solution with a mass concentration of 5%, adding emulsifier SDS and regulator polyvinyl alcohol to the lignin solution with a mass concentration of 5%, and mixing Evenly as a mesophase solution; wherein, the added emulsifier SDS accounts for 1% of the mass of the resulting mesophase solution, and the added regulator polyvinyl alcohol accounts for 2% of the mass of the resulting mesophase solution;

[0032] (3) Preparation of the external phase solution: adding the surfactant Span80 into the organic solvent liquid paraffin, mixing, and preparing...

Embodiment 2

[0036] A preparation method of lignin drug slow-release microspheres, the operation steps are as follows:

[0037] (1) Preparation of the internal phase solution: dissolving the drug orlistat in the organic solvent ethyl acetate to prepare an organic solution with a mass concentration of 10%, as the internal phase solution;

[0038] (2) Preparation of the mesophase solution: the hydrolyzed lignin is dissolved in water to prepare a lignin aqueous solution with a mass concentration of 10%, and emulsifiers OP-10 and SDBS (OP-10 mixed with SDBS at a mass ratio of 1:1) and regulator polyethylene glycol, and mixed uniformly as a mesophase solution; wherein, the added emulsifier accounted for 3% of the mass of the obtained mesophase solution, and the added regulator accounted for the obtained mesophase solution 4% of mass;

[0039] (3) Preparation of the external phase solution: adding surfactants Span60 and DC0749 (Span60 and DC0749 are mixed at a mass ratio of 1:1) into the organi...

Embodiment 3

[0043] A preparation method of lignin drug slow-release microspheres, the operation steps are as follows:

[0044] (1) Preparation of the internal phase solution: dissolving the drug orlistat in the organic solvent ethyl formate to prepare an organic solution with a mass concentration of 20%, as the internal phase solution;

[0045] (2) Preparation of mesophase solution: ethanol lignin is dissolved in water and is prepared into a lignin aqueous solution with a mass concentration of 20%, and emulsifiers OP-7, OP-15 (OP -7 and OP-15 are mixed in a mass ratio of 1:1) and regulator sodium carboxymethyl cellulose, mixed uniformly as a mesophase solution; wherein, the added emulsifier accounts for 5% of the quality of the gained mesophase solution, and the added regulator The agent accounts for 6% of the obtained mesophase solution quality;

[0046] (3) Preparation of the external phase solution: adding surfactants DC0749 and Tween20 (DC0749 and Tween20 are mixed in a mass ratio of...

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Abstract

The invention discloses a preparation method for lignin drug sustained release microspheres. The preparation method comprises the steps of (1) preparation of an internal phase solution; (2) preparation of a middle phase solution; (3) preparation of an external phase solution; (4) preparation of an oil-water-oil (o/w/o) dual emulsion; and (5) synthesis of mono-dispersed lignin drug sustained release microspheres. By adoption of the preparation method for the lignin drug sustained release microspheres disclosed by the invention, the obtained microspheres are uniform in particle size and controllable in appearance, and have the characteristics of environment protection, non-toxic property and the like; in addition, the preparation method is simple and effective, low in cost, and capable of effectively controlling release of a target drug, so that an efficient, simple and convenient method is provided for drug release; and therefore, the preparation method has high industrial application prospect.

Description

technical field [0001] The invention relates to a preparation method of lignin microspheres, in particular to a preparation method of lignin medicine slow-release microspheres. Background technique [0002] Sustained drug release is the combination (or encapsulation, compounding) of drug active molecules with polymer carriers, into the living body, and then the drug active molecules are released continuously, and the human body is continuously absorbed as the drug is released, so that the blood The concentration will not rise too high in an instant, and the drug can keep entering the body uninterruptedly, giving full play to the curative effect of the drug, thereby reducing the trouble of taking the drug for patients, and can maintain the stability of the blood drug concentration and reduce the side effects of the drug. [0003] The key to drug sustained and controlled release technology lies in the drug carrier. Depending on the drug carrier, the drug sustained release beha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/113A61K47/30A61K31/365
CPCA61K9/0002A61K9/113A61K9/1629A61K31/365
Inventor 李志礼葛圆圆黄文星
Owner GUANGXI UNIV
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