Curcumin nano-micelle oral suspension, gel and application thereof

An oral suspension and nanomicelle technology, applied in the directions of liquid transportation, dispersion transportation, emulsion transportation, etc., can solve the problems of high plasma triglyceride concentration, restrict development and application, and low bioavailability, and achieve The effect of low dosage, high synthesis efficiency and high bioavailability

Inactive Publication Date: 2017-05-10
GUANGZHOU BAIEN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(4) Lack of exercise: The plasma triglyceride concentration of people who are used to sitting still is higher than that of those who insist on physical exercise
[0006] The main chain of curcumin is an unsa

Method used

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  • Curcumin nano-micelle oral suspension, gel and application thereof
  • Curcumin nano-micelle oral suspension, gel and application thereof
  • Curcumin nano-micelle oral suspension, gel and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]1. Preparation of 0.1% Curcumin Nanomicelle Oral Suspension

[0039]

[0040] Preparation method: Weigh 0.1 g of curcumin and 0.5 g of chitosan nano-micelle drug carrier, put them into a grinding jar, close them after mixing, lock them on the grinder, and grind for 1 hour at 500 rpm; open the grinding jar, add spit Temperature 80 0.5g, turn off, grind for 1h under the same conditions; open the grinding tank, add 0.5g of propylene glycol, turn off, grind for 1h under the same conditions, add a small amount of medicinal pure water for washing, add to 100mL, filter with a microporous membrane, and bottle , that is.

[0041] 2. Preparation of curcumin nanomicelle gel

[0042] Preparation method: 1) Weigh 10g of borneol, add 20mL of 95% ethanol, stir to dissolve, add 1.5g of chitosan nano-micelle drug carrier, stir and mix, filter, recover ethanol, and vacuum dry at 70°C to obtain 8g of chitosan Nano ice flakes;

[0043] 2) Take 100mL curcumin nanomicelle oral suspensio...

Embodiment 2

[0045] 1. Preparation of 0.5% Curcumin Nanomicelle Oral Liquid

[0046]

[0047] Preparation method: Weigh 0.5 g of curcumin and 1.0 g of chitosan nano-micelle drug carrier, put them into a grinding jar, close them after mixing, lock them on the grinder, and grind for 1 hour at 500 rpm; open the grinding jar, add podium Loxamer 1.0g, turn off, grind for 1h under the same conditions; open the grinding tank, add 1.0g of ethanol, turn off, grind for 1h under the same conditions, add a small amount of medicinal pure water for washing, add to 100mL, filter with a microporous membrane, pack bottle, ready to serve.

[0048] 2. Preparation of curcumin nanomicelle gel

[0049] Preparation method: 1) Weigh 10g of borneol, add 20mL of 95% ethanol, stir to dissolve, add 1.5g of chitosan nano-micelle drug carrier, stir and mix, filter, recover ethanol, and vacuum dry at 70°C to obtain 8g of chitosan Nano ice flakes;

[0050] 2) Measure 100mL curcumin nanomicelle oral suspension, add ...

Embodiment 3

[0052] 1. Preparation of 0.25% Curcumin Nanomicelle Oral Liquid

[0053]

[0054] Preparation method: Weigh 0.25g of curcumin and 0.75g of chitosan nano-micelle drug carrier, put them into the grinding jar, close them after mixing, lock them on the grinder, and grind at 500rpm for 1h; open the grinding jar, add sucrose Fatty acid ester 0.75g, close, grind for 1h under the same conditions; open the grinding tank, add polyethylene glycol 0.75g, close, grind for 1h under the same conditions, add a small amount of medicinal pure water to wash, add to 100mL, microporous membrane Filter, bottle, and get ready.

[0055] 2. Preparation of curcumin nanomicelle gel

[0056] Preparation method: 1) Weigh 10g of borneol, add 20mL of 95% ethanol, stir to dissolve, add 1.5g of chitosan nano-micelle drug carrier, stir and mix, filter, recover ethanol, and vacuum dry at 70°C to obtain 8g of chitosan Nano ice flakes;

[0057] 2) Measure 100mL curcumin nanomicelle oral suspension, add 4.0g...

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PUM

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Abstract

The invention provides curcumin nano-micelle oral suspension. The curcumin nano-micelle oral suspension comprises the following active ingredients: curcumin, a chitosan nano-micelle drug carrier, a surfactant, a cosurfactant and purified water. The invention further provides curcumin nano-micelle gel. The curcumin nano-micelle oral suspension and the curcumin nano-micelle gel have good drug stability, safety and effectiveness, and can effectively treat diseases such as hyperlipidemia, sinusitis, gingivitis and cervicitis.

Description

technical field [0001] The invention belongs to the technical field of medicines, and mainly relates to a nano-micelle oral suspension and gel containing curcumin medicine, and the application of the two. Background technique [0002] Hyperlipidemia is a common disease caused by abnormal lipid metabolism in the human body. It mainly refers to excessively high levels of total cholesterol, triglycerides, and low-density lipoproteins or low levels of high-density lipoproteins in serum. Hyperlipidemia has no obvious clinical symptoms in the early stage, and its damage to the body is hidden, gradual, and systemic. Because hyperlipidemia can accelerate atherosclerosis, once the arteries are blocked, it will cause many diseases, such as cardiovascular and cerebrovascular diseases, kidney diseases, liver diseases and so on. Cardiovascular and cerebrovascular diseases are the main cause of death among middle-aged and elderly people and the number one killer threatening human health....

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K9/10A61K9/06A61K47/36A61K47/10A61K31/12A61P3/06A61P31/04A61P29/00A61P39/06
CPCA61K9/0095A61K9/06A61K9/10A61K9/1075A61K31/12A61K47/10A61K47/36
Inventor 陈松伟陈诗敏陈静婉曾淑琴
Owner GUANGZHOU BAIEN BIOTECH CO LTD
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