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Nano-mesoporous granular drug carrier with photothermal effect and preparation method of nano-mesoporous granular drug carrier

A nano-mesoporous, photothermal effect technology, applied in the directions of non-active ingredients medical preparations, active ingredients-containing medical preparations, drug combinations, etc. Achieve good photothermal effect, good encapsulation effect, and not easy to leak.

Inactive Publication Date: 2017-05-10
HUANGGANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The pathogenesis of cancer is extremely complex, cancer cells generally have multi-drug resistance, and it is difficult to obtain good therapeutic effect with single-drug chemotherapy

Method used

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  • Nano-mesoporous granular drug carrier with photothermal effect and preparation method of nano-mesoporous granular drug carrier
  • Nano-mesoporous granular drug carrier with photothermal effect and preparation method of nano-mesoporous granular drug carrier
  • Nano-mesoporous granular drug carrier with photothermal effect and preparation method of nano-mesoporous granular drug carrier

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Experimental program
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preparation example Construction

[0036] The specific steps of the preparation method of the nano-mesoporous particle drug carrier capable of efficiently delivering anticancer drugs and photothermal effects are as follows:

[0037]Step 1, completely dissolve the surfactant and co-solvent triethanolamine in water at 80°C, then slowly add silicon source and stir rapidly for 1-4 hours, centrifuge to obtain white colloidal particles, wash with ethanol several times and dry, after drying The product is calcined to remove the organic template to obtain nanometer mesoporous silica particles. The molar ratio of each reactant is: 1~5 surfactant: 10~50 silicon source: 1~10 cosolvent: 2000~6000 water;

[0038] Step 2: Add the nanometer mesoporous silica particles and aminosilane coupling agent obtained in step 1 into anhydrous toluene at a ratio of 1g / 0.2ml~1g / 2ml, and stir at 120°C for 12~ For 48 hours, filter, wash with toluene, wash with absolute ethanol, and dry to obtain amino-modified nanometer mesoporous silica pa...

Embodiment 1

[0044] The nano-mesoporous particle drug carrier provided in this embodiment includes nano-mesoporous silicon oxide particles and graphene oxide quantum dots adsorbed on the surface of the nano-mesoporous silicon oxide particles. The preparation method of the nano-mesoporous particle drug carrier comprises the following steps:

[0045] Step 1, dissolve 0.6836 g of cetyltrimethylammonium p-toluenesulfonate and 0.4 g of triethanolamine in 60 ml of deionized water; then slowly add 4 ml of ethyl orthosilicate at a reaction temperature of 80°C; continue After rapid stirring for 2 hours, centrifuge to obtain white colloidal particles, wash with ethanol several times and then vacuum-dry at 60°C. The dried white colloidal particles are calcined at 650°C for 6 hours to remove surfactants and obtain nanometer mesoporous silica particles ;

[0046] Step 2: Disperse 0.5 g of the nanometer mesoporous silica particles obtained in Step 1 in 80 ml of toluene and stir at 120° C. for 1 hour, t...

Embodiment 2

[0058] The preparation method of the nano-mesoporous particle drug carrier provided in this embodiment includes the following steps:

[0059] Step 1, 0.5466 gram cetyltrimethylammonium bromide and 0.4 gram triethanolamine are dissolved in 60 milliliters of deionized water; Then in 80 oC Slowly add 5 milliliters of tetraethyl orthosilicate at the reaction temperature; after continuing to stir rapidly for 2 hours, centrifuge to obtain white colloidal particles, wash with ethanol several times and then at 60 o C under vacuum drying, the white colloidal particles after drying at 650 o Calcining at C for 6h to remove the surfactant to obtain nanometer mesoporous silicon oxide particles;

[0060] Step 2, 0.5 gram of nano-mesoporous silica particles obtained in Step 1 are dispersed in 80 milliliters of toluene and heated at 120 o C stirred for 1 hour, then 0.75 ml of γ-aminopropyltriethoxysilane was added rapidly and continued at 120 oC stirred for 24 hours; adopt high-speed centr...

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Abstract

The invention discloses a nano-mesoporous granular drug carrier with the photothermal effect and a preparation method of the nano-mesoporous granular drug carrier, and solves the problems of single treatment method, large toxic and / or side effects, poor effect and the like in the prior art. The preparation method is characterized by comprising the following steps: preparing mesoporous silica nano particles with adjustable particle size and aperture from a surfactant serving as a structure-directing agent and tetraethoxysilane serving as a silicon source through a sol-gel self-assembling process; through modification with an amino functional group, storing a large content of anti-cancer drugs in mesoporous channels of the mesoporous silica nano particles; adsorbing graphene quantum dots on the surfaces of the mesoporous silica nano particles to obtain the nano-mesoporous granular drug carrier which can efficiently convey the anti-cancer drugs and has the photothermal effect. The particle size of the drug carrier is 20 to 200 nm, and the mesoporous aperture is 2 to 10 nm; the mesoporous channels are in tree branch-shaped distribution. The nano-mesoporous granular drug carrier has the function of pH responsive and controlled release of the anti-cancer drugs and the good photothermal effect, has the advantages of realizing a medical chemotherapy and photothermal therapy combination cancer treatment method and has a wide popularization and application value.

Description

[0001] Technical field: [0002] The invention belongs to the fields of medicine and nanometer materials, and in particular relates to a nano mesoporous particle drug carrier with photothermal effect and a preparation method thereof. [0003] Background technique: [0004] At present, cancer is one of the major diseases that threaten human life and health. The high incidence of cancer is a major problem facing the world. Clinically, cancer treatment methods include surgery, radiation therapy, drug chemotherapy, hyperthermia, etc. Among them, drug chemotherapy is a common method in cancer treatment, but many chemotherapeutic drugs are easily degraded and cleared during transportation in the body, have poor drug selectivity, and are difficult to reach cancer cells specifically; most chemotherapeutic drugs are highly toxic and easy to Causes very toxic side effects on normal cells. Therefore, using nano drug carriers to deliver anticancer drugs is one of the most effective ways....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/704A61K9/16A61K47/02A61K47/52A61K47/69A61P35/00
CPCA61K41/0052A61K9/1611A61K31/704A61K2300/00
Inventor 朱钰方田正芳
Owner HUANGGANG NORMAL UNIV
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